Abstract
Endogenous and environmental genotoxic agents produce DNA damage and induce cell death and mutations. The repair mechanisms of base lesions and single and double strand breaks have been well characterized in both prokaryotic and eukaryotic cells. However, the molecular pathways that repair or tolerate DNA-protein crosslinks (DPCs) remains to be largely elucidated. In this study, we constructed DNA substrates containing defined DPCs and assessed the incision activities of prokaryotic and eukaryotic nucleotide excision repair systems for DPCs in vitro.
| Original language | English |
|---|---|
| Pages (from-to) | 225-226 |
| Number of pages | 2 |
| Journal | Nucleic acids symposium series (2004) |
| Issue number | 53 |
| Publication status | Published - Dec 1 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Comparison of the activities of bacterial and mammalian nucleotide excision repair systems for DNA-protein crosslinks. / Nakano, Toshiaki; Salem, Amir M.H.; Terato, Hiroaki; Pack, Seung Pil; Makino, Keisuke; Ide, Hiroshi.
In: Nucleic acids symposium series (2004), No. 53, 01.12.2009, p. 225-226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of the activities of bacterial and mammalian nucleotide excision repair systems for DNA-protein crosslinks.
AU - Nakano, Toshiaki
AU - Salem, Amir M.H.
AU - Terato, Hiroaki
AU - Pack, Seung Pil
AU - Makino, Keisuke
AU - Ide, Hiroshi
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Endogenous and environmental genotoxic agents produce DNA damage and induce cell death and mutations. The repair mechanisms of base lesions and single and double strand breaks have been well characterized in both prokaryotic and eukaryotic cells. However, the molecular pathways that repair or tolerate DNA-protein crosslinks (DPCs) remains to be largely elucidated. In this study, we constructed DNA substrates containing defined DPCs and assessed the incision activities of prokaryotic and eukaryotic nucleotide excision repair systems for DPCs in vitro.
AB - Endogenous and environmental genotoxic agents produce DNA damage and induce cell death and mutations. The repair mechanisms of base lesions and single and double strand breaks have been well characterized in both prokaryotic and eukaryotic cells. However, the molecular pathways that repair or tolerate DNA-protein crosslinks (DPCs) remains to be largely elucidated. In this study, we constructed DNA substrates containing defined DPCs and assessed the incision activities of prokaryotic and eukaryotic nucleotide excision repair systems for DPCs in vitro.
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UR - http://www.scopus.com/inward/citedby.url?scp=77952468523&partnerID=8YFLogxK
M3 - Article
SP - 225
EP - 226
JO - Nucleic acids symposium series (2004)
JF - Nucleic acids symposium series (2004)
SN - 1746-8272
IS - 53
ER -