Comparison of the activities of bacterial and mammalian nucleotide excision repair systems for DNA-protein crosslinks.

Toshiaki Nakano; Amir M.H. Salem; Hiroaki Terato; Seung Pil Pack; Keisuke Makino; Hiroshi Ide

Comparison of the activities of bacterial and mammalian nucleotide excision repair systems for DNA-protein crosslinks.

Toshiaki Nakano, Amir M.H. Salem, Hiroaki Terato, Seung Pil Pack, Keisuke Makino, Hiroshi Ide

Research output: Contribution to journal › Article

Abstract

Endogenous and environmental genotoxic agents produce DNA damage and induce cell death and mutations. The repair mechanisms of base lesions and single and double strand breaks have been well characterized in both prokaryotic and eukaryotic cells. However, the molecular pathways that repair or tolerate DNA-protein crosslinks (DPCs) remains to be largely elucidated. In this study, we constructed DNA substrates containing defined DPCs and assessed the incision activities of prokaryotic and eukaryotic nucleotide excision repair systems for DPCs in vitro.

Original language	English
Pages (from-to)	225-226
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	53
Publication status	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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title = "Comparison of the activities of bacterial and mammalian nucleotide excision repair systems for DNA-protein crosslinks.",

abstract = "Endogenous and environmental genotoxic agents produce DNA damage and induce cell death and mutations. The repair mechanisms of base lesions and single and double strand breaks have been well characterized in both prokaryotic and eukaryotic cells. However, the molecular pathways that repair or tolerate DNA-protein crosslinks (DPCs) remains to be largely elucidated. In this study, we constructed DNA substrates containing defined DPCs and assessed the incision activities of prokaryotic and eukaryotic nucleotide excision repair systems for DPCs in vitro.",

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AU - Salem, Amir M.H.

AU - Terato, Hiroaki

AU - Pack, Seung Pil

AU - Makino, Keisuke

AU - Ide, Hiroshi

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AB - Endogenous and environmental genotoxic agents produce DNA damage and induce cell death and mutations. The repair mechanisms of base lesions and single and double strand breaks have been well characterized in both prokaryotic and eukaryotic cells. However, the molecular pathways that repair or tolerate DNA-protein crosslinks (DPCs) remains to be largely elucidated. In this study, we constructed DNA substrates containing defined DPCs and assessed the incision activities of prokaryotic and eukaryotic nucleotide excision repair systems for DPCs in vitro.

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