TY - JOUR
T1 - Comparison of serum ferritin and oxidative stress biomarkers between Japanese workers with and without metabolic syndrome
AU - Iwanaga, Suketaka
AU - Sakano, Noriko
AU - Taketa, Kazuhisa
AU - Takahashi, Noriko
AU - Wang, Da Hong
AU - Takahashi, Hidekazu
AU - Kubo, Masayuki
AU - Miyatake, Nobuyuki
AU - Ogino, Keiki
N1 - Funding Information:
This research was supported in part by funding from the Junpukai and in part from Health Science Center Foundation . We gratefully acknowledge the technical contribution from B. Wang, S. Rani, A. Miura, A. Horii, and T. Mitsumune.
PY - 2014/5/1
Y1 - 2014/5/1
N2 - Objective: Metabolic syndrome (MS) is closely associated to life-style and is characterized by central obesity causing severe diseases such as diabetes mellitus (DM) or atherosclerosis. This study investigates the role of oxidative stress and inflammation in MS. Subjects: Total of 685 workers stratified by gender (293 men and 392 women) with a mean age of 41.2 ± 10.4 in different offices in a city in Japan. Methods: Fasting blood and urine tests for MS, oxidative and/or inflammatory biomarker analysis and blood pressure (BP) measurement were performed. MS was defined on the basis of the Japanese criterion. Results: Serum ferritin and urinary hydrogen peroxide (H2O2) levels were significantly higher in subjects with MS than those without. Ferritin was positively correlated with 8-hydroxy-2′- deoxyguanosine (8-OHdG) in all subjects and it was negatively correlated with 8-isoprostane and H2O2in men. In addition, there was a significant positive correlation between ferritin and homeostasis model assessment (HOMA-R) in men. By using multiple regression analysis, ferritin was closely correlated with HOMA-R, γ-GT, 8-OHdG, smoking value and amount of alcohol ingestion in men, and it was correlated with 8-OHdG, γ-GT, HOMA-R in women under 50 years old. Conclusions: Ferritin is a useful marker of MS including insulin resistance, reflecting the importance of oxidative stress as a cause of MS, especially in men.
AB - Objective: Metabolic syndrome (MS) is closely associated to life-style and is characterized by central obesity causing severe diseases such as diabetes mellitus (DM) or atherosclerosis. This study investigates the role of oxidative stress and inflammation in MS. Subjects: Total of 685 workers stratified by gender (293 men and 392 women) with a mean age of 41.2 ± 10.4 in different offices in a city in Japan. Methods: Fasting blood and urine tests for MS, oxidative and/or inflammatory biomarker analysis and blood pressure (BP) measurement were performed. MS was defined on the basis of the Japanese criterion. Results: Serum ferritin and urinary hydrogen peroxide (H2O2) levels were significantly higher in subjects with MS than those without. Ferritin was positively correlated with 8-hydroxy-2′- deoxyguanosine (8-OHdG) in all subjects and it was negatively correlated with 8-isoprostane and H2O2in men. In addition, there was a significant positive correlation between ferritin and homeostasis model assessment (HOMA-R) in men. By using multiple regression analysis, ferritin was closely correlated with HOMA-R, γ-GT, 8-OHdG, smoking value and amount of alcohol ingestion in men, and it was correlated with 8-OHdG, γ-GT, HOMA-R in women under 50 years old. Conclusions: Ferritin is a useful marker of MS including insulin resistance, reflecting the importance of oxidative stress as a cause of MS, especially in men.
KW - 8-Hydroxy-2′-deoxyguanosine (8-OHdG)
KW - Ferritin
KW - Metabolic syndrome
KW - Oxidative stress
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U2 - 10.1016/j.orcp.2013.01.003
DO - 10.1016/j.orcp.2013.01.003
M3 - Article
C2 - 24847669
AN - SCOPUS:84900514861
SN - 1871-403X
VL - 8
SP - e271-e282
JO - Obesity Research and Clinical Practice
JF - Obesity Research and Clinical Practice
IS - 3
ER -
