Comparison of proliferation of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia

Kentaro Ohta, Masanori Iwai, Keiko Sato, Nobuhiko Omori, Isao Nagano, Mikio Shoji, Koji Abe

Research output: Contribution to journalArticle

Abstract

Oligodendrocyte progenitor cells (OPCs) mature to oligodendrocyte and remyelinate axons. OPCs express neuron-glial antigen 2 (NG2) chondroitin sulfate proteoglycan. We stained NG2 to investigate the effect of aging on the OPCs after cerebral ischemia. NG2 positive cells were examined 1, 3, 7 days after 90 min of transient middle cerebral artery occlusion (MCAO) in young and aged brains. The number of NG2 positive cells increased in the ischemic penumbra 3 and 7 days after reperfusion. At day 7, the number of NG2 positive cells was significantly greater in the young than the aged brains, and the processes of NG2 positive cells enlarged and were highly branched in the young than the aged brains. These results suggest that the young brain showed a higher potential of proliferation and process branching of OPCs than the aged brains.

Original languageEnglish
Pages (from-to)451-457
Number of pages7
JournalInternational Congress Series
Volume1252
Issue numberC
DOIs
Publication statusPublished - Jun 1 2003

Keywords

  • Aging
  • Neuron-glial antigen 2 (NG2)
  • Oligodendrocyte progenitor cell
  • Remyelination
  • Transient ischemia

ASJC Scopus subject areas

  • Medicine(all)

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