TY - JOUR
T1 - Comparison of proliferation of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia
AU - Ohta, Kentaro
AU - Iwai, Masanori
AU - Sato, Keiko
AU - Omori, Nobuhiko
AU - Nagano, Isao
AU - Shoji, Mikio
AU - Abe, Koji
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Oligodendrocyte progenitor cells (OPCs) mature to oligodendrocyte and remyelinate axons. OPCs express neuron-glial antigen 2 (NG2) chondroitin sulfate proteoglycan. We stained NG2 to investigate the effect of aging on the OPCs after cerebral ischemia. NG2 positive cells were examined 1, 3, 7 days after 90 min of transient middle cerebral artery occlusion (MCAO) in young and aged brains. The number of NG2 positive cells increased in the ischemic penumbra 3 and 7 days after reperfusion. At day 7, the number of NG2 positive cells was significantly greater in the young than the aged brains, and the processes of NG2 positive cells enlarged and were highly branched in the young than the aged brains. These results suggest that the young brain showed a higher potential of proliferation and process branching of OPCs than the aged brains.
AB - Oligodendrocyte progenitor cells (OPCs) mature to oligodendrocyte and remyelinate axons. OPCs express neuron-glial antigen 2 (NG2) chondroitin sulfate proteoglycan. We stained NG2 to investigate the effect of aging on the OPCs after cerebral ischemia. NG2 positive cells were examined 1, 3, 7 days after 90 min of transient middle cerebral artery occlusion (MCAO) in young and aged brains. The number of NG2 positive cells increased in the ischemic penumbra 3 and 7 days after reperfusion. At day 7, the number of NG2 positive cells was significantly greater in the young than the aged brains, and the processes of NG2 positive cells enlarged and were highly branched in the young than the aged brains. These results suggest that the young brain showed a higher potential of proliferation and process branching of OPCs than the aged brains.
KW - Aging
KW - Neuron-glial antigen 2 (NG2)
KW - Oligodendrocyte progenitor cell
KW - Remyelination
KW - Transient ischemia
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U2 - 10.1016/S0531-5131(03)00068-2
DO - 10.1016/S0531-5131(03)00068-2
M3 - Article
AN - SCOPUS:85023056782
SN - 0531-5131
VL - 1252
SP - 451
EP - 457
JO - International Congress Series
JF - International Congress Series
IS - C
ER -