Comparison of Pharmacological Effects of Tetrahydrocannabinols and Their 11-Hydroxy-Metabolites in Mice

Kazuhito Watanabe, Takako Kijima, Shizuo Narimatsu, Jun Nishikami, Ikuo Yamamoto, Y. Yoshimura

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Pharmacological effects (catalepsy, hypothermia, pentobarbital-induced sleep prolongation, anticonvulsant and analgesic effects) of Δ8- and Δ9-tetrahydrocannabinols, and their 11-hydroxy-metabolites were evaluated and compared in mice. Δ9-Tetrahydrocannabinol and 11-hydroxy-Δ9-tetrahydrocannabinol exhibited somewhat greater effects than did Δ8-tetrahydrocannabinol and 11-hydroxy-Δ8-tetrahydrocannabinol, respectively, in all pharmacological indices tested. Greater effects of 11-hydroxy-metabolites than those of tetrahydrocannabinols were also demonstrated.

Original languageEnglish
Pages (from-to)2317-2319
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume38
Issue number8
DOIs
Publication statusPublished - 1990
Externally publishedYes

Keywords

  • 11-hydroxy-Δ-tetrahydrocanna-binol
  • 11-hydroxy-Δ-tetrahydrocannabinol
  • analgesia
  • anticonvulsant effect
  • catalepsy
  • hypothermia
  • pentobarbital-induced sleep
  • Δ-tetrahydrocannabinol
  • Δ-tetrahydrocannabinol

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Comparison of Pharmacological Effects of Tetrahydrocannabinols and Their 11-Hydroxy-Metabolites in Mice'. Together they form a unique fingerprint.

Cite this