Comparison of Pharmacological Effects of Tetrahydrocannabinols and Their 11-Hydroxy-Metabolites in Mice

Kazuhito Watanabe; Takako Kijima; Shizuo Narimatsu; Jun Nishikami; Ikuo Yamamoto; Y. Yoshimura

doi:10.1248/cpb.38.2317

Comparison of Pharmacological Effects of Tetrahydrocannabinols and Their 11-Hydroxy-Metabolites in Mice

Kazuhito Watanabe, Takako Kijima, Shizuo Narimatsu, Jun Nishikami, Ikuo Yamamoto, Y. Yoshimura

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Pharmacological effects (catalepsy, hypothermia, pentobarbital-induced sleep prolongation, anticonvulsant and analgesic effects) of Δ⁸- and Δ⁹-tetrahydrocannabinols, and their 11-hydroxy-metabolites were evaluated and compared in mice. Δ⁹-Tetrahydrocannabinol and 11-hydroxy-Δ⁹-tetrahydrocannabinol exhibited somewhat greater effects than did Δ⁸-tetrahydrocannabinol and 11-hydroxy-Δ⁸-tetrahydrocannabinol, respectively, in all pharmacological indices tested. Greater effects of 11-hydroxy-metabolites than those of tetrahydrocannabinols were also demonstrated.

Original language	English
Pages (from-to)	2317-2319
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	38
Issue number	8
DOIs	https://doi.org/10.1248/cpb.38.2317
Publication status	Published - 1990
Externally published	Yes

Keywords

11-hydroxy-Δ-tetrahydrocanna-binol
11-hydroxy-Δ-tetrahydrocannabinol
analgesia
anticonvulsant effect
catalepsy
hypothermia
pentobarbital-induced sleep
Δ-tetrahydrocannabinol
Δ-tetrahydrocannabinol

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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title = "Comparison of Pharmacological Effects of Tetrahydrocannabinols and Their 11-Hydroxy-Metabolites in Mice",

abstract = "Pharmacological effects (catalepsy, hypothermia, pentobarbital-induced sleep prolongation, anticonvulsant and analgesic effects) of Δ8- and Δ9-tetrahydrocannabinols, and their 11-hydroxy-metabolites were evaluated and compared in mice. Δ9-Tetrahydrocannabinol and 11-hydroxy-Δ9-tetrahydrocannabinol exhibited somewhat greater effects than did Δ8-tetrahydrocannabinol and 11-hydroxy-Δ8-tetrahydrocannabinol, respectively, in all pharmacological indices tested. Greater effects of 11-hydroxy-metabolites than those of tetrahydrocannabinols were also demonstrated.",

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author = "Kazuhito Watanabe and Takako Kijima and Shizuo Narimatsu and Jun Nishikami and Ikuo Yamamoto and Y. Yoshimura",

year = "1990",

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language = "English",

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journal = "Chemical and Pharmaceutical Bulletin",

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T1 - Comparison of Pharmacological Effects of Tetrahydrocannabinols and Their 11-Hydroxy-Metabolites in Mice

AU - Watanabe, Kazuhito

AU - Kijima, Takako

AU - Narimatsu, Shizuo

AU - Nishikami, Jun

AU - Yamamoto, Ikuo

AU - Yoshimura, Y.

PY - 1990

Y1 - 1990

N2 - Pharmacological effects (catalepsy, hypothermia, pentobarbital-induced sleep prolongation, anticonvulsant and analgesic effects) of Δ8- and Δ9-tetrahydrocannabinols, and their 11-hydroxy-metabolites were evaluated and compared in mice. Δ9-Tetrahydrocannabinol and 11-hydroxy-Δ9-tetrahydrocannabinol exhibited somewhat greater effects than did Δ8-tetrahydrocannabinol and 11-hydroxy-Δ8-tetrahydrocannabinol, respectively, in all pharmacological indices tested. Greater effects of 11-hydroxy-metabolites than those of tetrahydrocannabinols were also demonstrated.

AB - Pharmacological effects (catalepsy, hypothermia, pentobarbital-induced sleep prolongation, anticonvulsant and analgesic effects) of Δ8- and Δ9-tetrahydrocannabinols, and their 11-hydroxy-metabolites were evaluated and compared in mice. Δ9-Tetrahydrocannabinol and 11-hydroxy-Δ9-tetrahydrocannabinol exhibited somewhat greater effects than did Δ8-tetrahydrocannabinol and 11-hydroxy-Δ8-tetrahydrocannabinol, respectively, in all pharmacological indices tested. Greater effects of 11-hydroxy-metabolites than those of tetrahydrocannabinols were also demonstrated.

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KW - 11-hydroxy-Δ-tetrahydrocannabinol

KW - analgesia

KW - anticonvulsant effect

KW - catalepsy

KW - hypothermia

KW - pentobarbital-induced sleep

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ER -

Comparison of Pharmacological Effects of Tetrahydrocannabinols and Their 11-Hydroxy-Metabolites in Mice

Abstract

Keywords

ASJC Scopus subject areas

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