Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers

Hiroko Masuda, Keith A. Baggerly, Ying Wang, Takayuki Iwamoto, Takae Brewer, Lajos Pusztai, Kazuharu Kai, Takahiro Kogawa, Pascal Finetti, Daniel Birnbaum, Luc Dirix, Wendy A. Woodward, James M. Reuben, Savitri Krishnamurthy, W. F. Symmans, Steven J. Van Laere, François Bertucci, Gabriel N. Hortobagyi, Naoto T. Ueno

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Introduction: Because of its high rate of metastasis, inflammatory breast cancer (IBC) has a poor prognosis compared with non-inflammatory types of breast cancer (non-IBC). In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer (TNBC). We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients.Methods: We determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known (39 cases of TN-IBC; 49 cases of TN-non-IBC). We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes.Results: We found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status (P = 0.47). TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort.Conclusions: Our data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC.

Original languageEnglish
Article numberR112
JournalBreast Cancer Research
Volume15
Issue number6
DOIs
Publication statusPublished - Nov 25 2013

Fingerprint

Inflammatory Breast Neoplasms
Triple Negative Breast Neoplasms
Breast Neoplasms
Recurrence
Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers. / Masuda, Hiroko; Baggerly, Keith A.; Wang, Ying; Iwamoto, Takayuki; Brewer, Takae; Pusztai, Lajos; Kai, Kazuharu; Kogawa, Takahiro; Finetti, Pascal; Birnbaum, Daniel; Dirix, Luc; Woodward, Wendy A.; Reuben, James M.; Krishnamurthy, Savitri; Symmans, W. F.; Van Laere, Steven J.; Bertucci, François; Hortobagyi, Gabriel N.; Ueno, Naoto T.

In: Breast Cancer Research, Vol. 15, No. 6, R112, 25.11.2013.

Research output: Contribution to journalArticle

Masuda, H, Baggerly, KA, Wang, Y, Iwamoto, T, Brewer, T, Pusztai, L, Kai, K, Kogawa, T, Finetti, P, Birnbaum, D, Dirix, L, Woodward, WA, Reuben, JM, Krishnamurthy, S, Symmans, WF, Van Laere, SJ, Bertucci, F, Hortobagyi, GN & Ueno, NT 2013, 'Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers', Breast Cancer Research, vol. 15, no. 6, R112. https://doi.org/10.1186/bcr3579
Masuda, Hiroko ; Baggerly, Keith A. ; Wang, Ying ; Iwamoto, Takayuki ; Brewer, Takae ; Pusztai, Lajos ; Kai, Kazuharu ; Kogawa, Takahiro ; Finetti, Pascal ; Birnbaum, Daniel ; Dirix, Luc ; Woodward, Wendy A. ; Reuben, James M. ; Krishnamurthy, Savitri ; Symmans, W. F. ; Van Laere, Steven J. ; Bertucci, François ; Hortobagyi, Gabriel N. ; Ueno, Naoto T. / Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers. In: Breast Cancer Research. 2013 ; Vol. 15, No. 6.
@article{30bf16fc0cf14b7aaf1d087496f47a38,
title = "Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers",
abstract = "Introduction: Because of its high rate of metastasis, inflammatory breast cancer (IBC) has a poor prognosis compared with non-inflammatory types of breast cancer (non-IBC). In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer (TNBC). We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients.Methods: We determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known (39 cases of TN-IBC; 49 cases of TN-non-IBC). We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes.Results: We found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status (P = 0.47). TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort.Conclusions: Our data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC.",
author = "Hiroko Masuda and Baggerly, {Keith A.} and Ying Wang and Takayuki Iwamoto and Takae Brewer and Lajos Pusztai and Kazuharu Kai and Takahiro Kogawa and Pascal Finetti and Daniel Birnbaum and Luc Dirix and Woodward, {Wendy A.} and Reuben, {James M.} and Savitri Krishnamurthy and Symmans, {W. F.} and {Van Laere}, {Steven J.} and Fran{\cc}ois Bertucci and Hortobagyi, {Gabriel N.} and Ueno, {Naoto T.}",
year = "2013",
month = "11",
day = "25",
doi = "10.1186/bcr3579",
language = "English",
volume = "15",
journal = "Breast Cancer Research",
issn = "1465-5411",
publisher = "BioMed Central",
number = "6",

}

TY - JOUR

T1 - Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers

AU - Masuda, Hiroko

AU - Baggerly, Keith A.

AU - Wang, Ying

AU - Iwamoto, Takayuki

AU - Brewer, Takae

AU - Pusztai, Lajos

AU - Kai, Kazuharu

AU - Kogawa, Takahiro

AU - Finetti, Pascal

AU - Birnbaum, Daniel

AU - Dirix, Luc

AU - Woodward, Wendy A.

AU - Reuben, James M.

AU - Krishnamurthy, Savitri

AU - Symmans, W. F.

AU - Van Laere, Steven J.

AU - Bertucci, François

AU - Hortobagyi, Gabriel N.

AU - Ueno, Naoto T.

PY - 2013/11/25

Y1 - 2013/11/25

N2 - Introduction: Because of its high rate of metastasis, inflammatory breast cancer (IBC) has a poor prognosis compared with non-inflammatory types of breast cancer (non-IBC). In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer (TNBC). We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients.Methods: We determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known (39 cases of TN-IBC; 49 cases of TN-non-IBC). We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes.Results: We found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status (P = 0.47). TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort.Conclusions: Our data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC.

AB - Introduction: Because of its high rate of metastasis, inflammatory breast cancer (IBC) has a poor prognosis compared with non-inflammatory types of breast cancer (non-IBC). In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer (TNBC). We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients.Methods: We determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known (39 cases of TN-IBC; 49 cases of TN-non-IBC). We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes.Results: We found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status (P = 0.47). TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort.Conclusions: Our data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC.

UR - http://www.scopus.com/inward/record.url?scp=84888126088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888126088&partnerID=8YFLogxK

U2 - 10.1186/bcr3579

DO - 10.1186/bcr3579

M3 - Article

C2 - 24274653

AN - SCOPUS:84888126088

VL - 15

JO - Breast Cancer Research

JF - Breast Cancer Research

SN - 1465-5411

IS - 6

M1 - R112

ER -