Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers

Hiroko Masuda, Keith A. Baggerly, Ying Wang, Takayuki Iwamoto, Takae Brewer, Lajos Pusztai, Kazuharu Kai, Takahiro Kogawa, Pascal Finetti, Daniel Birnbaum, Luc Dirix, Wendy A. Woodward, James M. Reuben, Savitri Krishnamurthy, W. F. Symmans, Steven J. Van Laere, François Bertucci, Gabriel N. Hortobagyi, Naoto T. Ueno

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


Introduction: Because of its high rate of metastasis, inflammatory breast cancer (IBC) has a poor prognosis compared with non-inflammatory types of breast cancer (non-IBC). In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer (TNBC). We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients.Methods: We determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known (39 cases of TN-IBC; 49 cases of TN-non-IBC). We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes.Results: We found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status (P = 0.47). TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort.Conclusions: Our data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC.

Original languageEnglish
Article numberR112
JournalBreast Cancer Research
Issue number6
Publication statusPublished - Nov 25 2013

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers'. Together they form a unique fingerprint.

Cite this