TY - JOUR
T1 - Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers
AU - Masuda, Hiroko
AU - Baggerly, Keith A.
AU - Wang, Ying
AU - Iwamoto, Takayuki
AU - Brewer, Takae
AU - Pusztai, Lajos
AU - Kai, Kazuharu
AU - Kogawa, Takahiro
AU - Finetti, Pascal
AU - Birnbaum, Daniel
AU - Dirix, Luc
AU - Woodward, Wendy A.
AU - Reuben, James M.
AU - Krishnamurthy, Savitri
AU - Symmans, W. F.
AU - Van Laere, Steven J.
AU - Bertucci, François
AU - Hortobagyi, Gabriel N.
AU - Ueno, Naoto T.
N1 - Funding Information:
We thank Ms. Sunita C. Patterson for editing. This research was supported by National Institutes of Health grants R01 CA123318 (NT Ueno) and CA016672 (MD Anderson Cancer Center Support Grant), the Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, and a State of Texas Rare and Aggressive Breast Cancer Research Program grant (NT Ueno).
PY - 2013/11/25
Y1 - 2013/11/25
N2 - Introduction: Because of its high rate of metastasis, inflammatory breast cancer (IBC) has a poor prognosis compared with non-inflammatory types of breast cancer (non-IBC). In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer (TNBC). We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients.Methods: We determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known (39 cases of TN-IBC; 49 cases of TN-non-IBC). We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes.Results: We found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status (P = 0.47). TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort.Conclusions: Our data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC.
AB - Introduction: Because of its high rate of metastasis, inflammatory breast cancer (IBC) has a poor prognosis compared with non-inflammatory types of breast cancer (non-IBC). In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer (TNBC). We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients.Methods: We determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known (39 cases of TN-IBC; 49 cases of TN-non-IBC). We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes.Results: We found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status (P = 0.47). TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort.Conclusions: Our data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC.
UR - http://www.scopus.com/inward/record.url?scp=84888126088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888126088&partnerID=8YFLogxK
U2 - 10.1186/bcr3579
DO - 10.1186/bcr3579
M3 - Article
C2 - 24274653
AN - SCOPUS:84888126088
VL - 15
JO - Breast Cancer Research
JF - Breast Cancer Research
SN - 1465-5411
IS - 6
M1 - R112
ER -
