Abstract
Introduction: Because of its high rate of metastasis, inflammatory breast cancer (IBC) has a poor prognosis compared with non-inflammatory types of breast cancer (non-IBC). In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer (TNBC). We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients.Methods: We determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known (39 cases of TN-IBC; 49 cases of TN-non-IBC). We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes.Results: We found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status (P = 0.47). TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort.Conclusions: Our data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC.
| Original language | English |
|---|---|
| Article number | R112 |
| Journal | Breast Cancer Research |
| Volume | 15 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Nov 25 2013 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
- Medicine(all)
Cite this
Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers. / Masuda, Hiroko; Baggerly, Keith A.; Wang, Ying; Iwamoto, Takayuki; Brewer, Takae; Pusztai, Lajos; Kai, Kazuharu; Kogawa, Takahiro; Finetti, Pascal; Birnbaum, Daniel; Dirix, Luc; Woodward, Wendy A.; Reuben, James M.; Krishnamurthy, Savitri; Symmans, W. F.; Van Laere, Steven J.; Bertucci, François; Hortobagyi, Gabriel N.; Ueno, Naoto T.
In: Breast Cancer Research, Vol. 15, No. 6, R112, 25.11.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers
AU - Masuda, Hiroko
AU - Baggerly, Keith A.
AU - Wang, Ying
AU - Iwamoto, Takayuki
AU - Brewer, Takae
AU - Pusztai, Lajos
AU - Kai, Kazuharu
AU - Kogawa, Takahiro
AU - Finetti, Pascal
AU - Birnbaum, Daniel
AU - Dirix, Luc
AU - Woodward, Wendy A.
AU - Reuben, James M.
AU - Krishnamurthy, Savitri
AU - Symmans, W. F.
AU - Van Laere, Steven J.
AU - Bertucci, François
AU - Hortobagyi, Gabriel N.
AU - Ueno, Naoto T.
PY - 2013/11/25
Y1 - 2013/11/25
N2 - Introduction: Because of its high rate of metastasis, inflammatory breast cancer (IBC) has a poor prognosis compared with non-inflammatory types of breast cancer (non-IBC). In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer (TNBC). We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients.Methods: We determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known (39 cases of TN-IBC; 49 cases of TN-non-IBC). We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes.Results: We found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status (P = 0.47). TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort.Conclusions: Our data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC.
AB - Introduction: Because of its high rate of metastasis, inflammatory breast cancer (IBC) has a poor prognosis compared with non-inflammatory types of breast cancer (non-IBC). In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer (TNBC). We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients.Methods: We determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known (39 cases of TN-IBC; 49 cases of TN-non-IBC). We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes.Results: We found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status (P = 0.47). TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort.Conclusions: Our data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC.
UR - http://www.scopus.com/inward/record.url?scp=84888126088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888126088&partnerID=8YFLogxK
U2 - 10.1186/bcr3579
DO - 10.1186/bcr3579
M3 - Article
C2 - 24274653
AN - SCOPUS:84888126088
VL - 15
JO - Breast Cancer Research
JF - Breast Cancer Research
SN - 1465-5411
IS - 6
M1 - R112
ER -