Comparison of field-in-field radiotherapy with conformal radiotherapy for unilateral cervical malignant lymphoma

Mako Yamashita, Norihisa Katayama, Takahiro Waki, Kuniaki Katsui, Kengo Himei, Mitsuhiro Takemoto, Susumu Kanazawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This study compared field-in-field (FIF) radiotherapy with conformal radiotherapy with physical wedges for the treatment of unilateral cervical malignant lymphoma. Two treatment plans, the FIF technique and conformal RT, were generated for each of 32 patients with unilateral cervical malignant lymphoma. To compare the 2 treatment plans, dose-volume histograms of the planning target volume (PTV), the thyroid, submandibular gland, carotid artery, mucosa, spinal cord, and surrounding normal tissue, and monitor unit (MU) were analyzed. The FIF technique showed significant reduction in the mean dose of thyroid, submandibular gland, carotid artery and mucosa, the maximum dose of the spinal cord and PTV, and the volume receiving > 107% of the prescribed dose of surrounding normal tissue (p <0.001). In addition, there were gains in the homogeneity index of the PTV for FIF. Furthermore, the total MU was also lower for the FIF technique than for the wedge technique (p <0.001). Compared with the wedge technique, the FIF technique improved the dose homogeneity of the PTV, reduced the dose to normal structures, and was associated with fewer MUs in the treatment of patients with cervical malignant lymphoma.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalActa Medica Okayama
Volume69
Issue number4
Publication statusPublished - 2015

Fingerprint

Conformal Radiotherapy
Radiotherapy
Lymphoma
Planning
Submandibular Gland
Carotid Arteries
Spinal Cord
Thyroid Gland
Mucous Membrane
Tissue
Therapeutics

Keywords

  • Dose-volume histogram
  • Field-in-field technique
  • Lymphoma
  • Monitor units
  • Wedge

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Comparison of field-in-field radiotherapy with conformal radiotherapy for unilateral cervical malignant lymphoma. / Yamashita, Mako; Katayama, Norihisa; Waki, Takahiro; Katsui, Kuniaki; Himei, Kengo; Takemoto, Mitsuhiro; Kanazawa, Susumu.

In: Acta Medica Okayama, Vol. 69, No. 4, 2015, p. 189-195.

Research output: Contribution to journalArticle

@article{0e343e683d864f56a553c9c60f60e40e,
title = "Comparison of field-in-field radiotherapy with conformal radiotherapy for unilateral cervical malignant lymphoma",
abstract = "This study compared field-in-field (FIF) radiotherapy with conformal radiotherapy with physical wedges for the treatment of unilateral cervical malignant lymphoma. Two treatment plans, the FIF technique and conformal RT, were generated for each of 32 patients with unilateral cervical malignant lymphoma. To compare the 2 treatment plans, dose-volume histograms of the planning target volume (PTV), the thyroid, submandibular gland, carotid artery, mucosa, spinal cord, and surrounding normal tissue, and monitor unit (MU) were analyzed. The FIF technique showed significant reduction in the mean dose of thyroid, submandibular gland, carotid artery and mucosa, the maximum dose of the spinal cord and PTV, and the volume receiving > 107{\%} of the prescribed dose of surrounding normal tissue (p <0.001). In addition, there were gains in the homogeneity index of the PTV for FIF. Furthermore, the total MU was also lower for the FIF technique than for the wedge technique (p <0.001). Compared with the wedge technique, the FIF technique improved the dose homogeneity of the PTV, reduced the dose to normal structures, and was associated with fewer MUs in the treatment of patients with cervical malignant lymphoma.",
keywords = "Dose-volume histogram, Field-in-field technique, Lymphoma, Monitor units, Wedge",
author = "Mako Yamashita and Norihisa Katayama and Takahiro Waki and Kuniaki Katsui and Kengo Himei and Mitsuhiro Takemoto and Susumu Kanazawa",
year = "2015",
language = "English",
volume = "69",
pages = "189--195",
journal = "Acta Medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "4",

}

TY - JOUR

T1 - Comparison of field-in-field radiotherapy with conformal radiotherapy for unilateral cervical malignant lymphoma

AU - Yamashita, Mako

AU - Katayama, Norihisa

AU - Waki, Takahiro

AU - Katsui, Kuniaki

AU - Himei, Kengo

AU - Takemoto, Mitsuhiro

AU - Kanazawa, Susumu

PY - 2015

Y1 - 2015

N2 - This study compared field-in-field (FIF) radiotherapy with conformal radiotherapy with physical wedges for the treatment of unilateral cervical malignant lymphoma. Two treatment plans, the FIF technique and conformal RT, were generated for each of 32 patients with unilateral cervical malignant lymphoma. To compare the 2 treatment plans, dose-volume histograms of the planning target volume (PTV), the thyroid, submandibular gland, carotid artery, mucosa, spinal cord, and surrounding normal tissue, and monitor unit (MU) were analyzed. The FIF technique showed significant reduction in the mean dose of thyroid, submandibular gland, carotid artery and mucosa, the maximum dose of the spinal cord and PTV, and the volume receiving > 107% of the prescribed dose of surrounding normal tissue (p <0.001). In addition, there were gains in the homogeneity index of the PTV for FIF. Furthermore, the total MU was also lower for the FIF technique than for the wedge technique (p <0.001). Compared with the wedge technique, the FIF technique improved the dose homogeneity of the PTV, reduced the dose to normal structures, and was associated with fewer MUs in the treatment of patients with cervical malignant lymphoma.

AB - This study compared field-in-field (FIF) radiotherapy with conformal radiotherapy with physical wedges for the treatment of unilateral cervical malignant lymphoma. Two treatment plans, the FIF technique and conformal RT, were generated for each of 32 patients with unilateral cervical malignant lymphoma. To compare the 2 treatment plans, dose-volume histograms of the planning target volume (PTV), the thyroid, submandibular gland, carotid artery, mucosa, spinal cord, and surrounding normal tissue, and monitor unit (MU) were analyzed. The FIF technique showed significant reduction in the mean dose of thyroid, submandibular gland, carotid artery and mucosa, the maximum dose of the spinal cord and PTV, and the volume receiving > 107% of the prescribed dose of surrounding normal tissue (p <0.001). In addition, there were gains in the homogeneity index of the PTV for FIF. Furthermore, the total MU was also lower for the FIF technique than for the wedge technique (p <0.001). Compared with the wedge technique, the FIF technique improved the dose homogeneity of the PTV, reduced the dose to normal structures, and was associated with fewer MUs in the treatment of patients with cervical malignant lymphoma.

KW - Dose-volume histogram

KW - Field-in-field technique

KW - Lymphoma

KW - Monitor units

KW - Wedge

UR - http://www.scopus.com/inward/record.url?scp=84940980614&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940980614&partnerID=8YFLogxK

M3 - Article

VL - 69

SP - 189

EP - 195

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 4

ER -