Comparing the cochlear spiral modiolar artery in type-1 and type-2 diabetes mellitus: A human temporal bone study

Shin Kariya, Sebahattin Cureoglu, Hisaki Fukushima, Norimasa Morita, Muzeyyen Y. Baylan, Yukihide Maeda, Kazunori Nishizaki, Michael M. Paparella

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17 Citations (Scopus)

Abstract

This study examined whether pathological findings were present in cochlear vessels for patients with diabetes mellitus. Twenty-six temporal bones from 13 patients with type 1 diabetes mellitus and 40 temporal bones from 20 patients with type 2 diabetes mellitus were examined. Type 2 diabetic temporal bones were divided into 2 groups according to diabetic management (22 temporal bones with insulin therapy, and 18 with oral hypoglycemic drugs). Age-matched normal control temporal bones were also selected. The vessel wall thickness in the cochlear spiral modiolar artery was measured under a light microscope, and the vessel wall ratio (vessel wall thickness/outer diameter of the vessel × 100) was calculated. The vessel wall thickness and vessel wall ratio in type 1 diabetes mellitus were significantly greater than in normal controls. Type 2 diabetic patients with insulin therapy showed significantly greater vessel wall thickness and vessel wall ratios than controls. In type 2 diabetes mellitus, the vessel wall thickness and vessel wall ratio were greater in patients treated with insulin therapy than in those treated with oral hypoglycemic agents. Type 2 diabetic patients with insulin therapy showed an increased vessel wall thickness and vessel wall ratio compared to patients with type 1 diabetes mellitus. In conclusion, the cochlea in patients with diabetes mellitus shows circulatory disturbance compared to age-matched normal controls.

Original languageEnglish
Pages (from-to)375-383
Number of pages9
JournalActa medica Okayama
Volume64
Issue number6
Publication statusPublished - Dec 2010

Keywords

  • Cochlear spiral modiolar artery
  • Diabetes mellitus
  • Hearing loss
  • Temporal bone

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Kariya, S., Cureoglu, S., Fukushima, H., Morita, N., Baylan, M. Y., Maeda, Y., Nishizaki, K., & Paparella, M. M. (2010). Comparing the cochlear spiral modiolar artery in type-1 and type-2 diabetes mellitus: A human temporal bone study. Acta medica Okayama, 64(6), 375-383.