TY - JOUR
T1 - Comparative uptake behavior of trace elements in adult and suckling rat lens
AU - Nabekura, Tomohiro
AU - Minami, Takeshi
AU - Hirunuma, Rieko
AU - Enomoto, Shuichi
AU - Hori, Ryohei
AU - Ito, Yoshimasa
PY - 2001/6/21
Y1 - 2001/6/21
N2 - The multitracer technique was applied to the determination of the uptake of trace elements in the lenses of adult and suckling rats to investigate the transport mechanisms of trace elements during developmental maturation. Be, Sc, V, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Y, Zr, Ru and Rh accumulate in adult and suckling rat lenses. The rates of uptake of trace elements differ among each species and also differ between adult and suckling rat lenses. The uptakes of Fe and Sr are greater in adult rat lenses, while the uptakes of Se and Rb are greater in suckling rat lenses. High concentrations of Zn are transported into the lenses of both adult and suckling rats in comparison with other elements, and the content of Zn in suckling rat lens is higher than in adult lens. The present study suggests that different mechanisms depending on the stage of development act to transport trace elements into lenses.
AB - The multitracer technique was applied to the determination of the uptake of trace elements in the lenses of adult and suckling rats to investigate the transport mechanisms of trace elements during developmental maturation. Be, Sc, V, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Y, Zr, Ru and Rh accumulate in adult and suckling rat lenses. The rates of uptake of trace elements differ among each species and also differ between adult and suckling rat lenses. The uptakes of Fe and Sr are greater in adult rat lenses, while the uptakes of Se and Rb are greater in suckling rat lenses. High concentrations of Zn are transported into the lenses of both adult and suckling rats in comparison with other elements, and the content of Zn in suckling rat lens is higher than in adult lens. The present study suggests that different mechanisms depending on the stage of development act to transport trace elements into lenses.
KW - Crystalline lens
KW - Multitracer
KW - Suckling rat
KW - Trace elements
UR - http://www.scopus.com/inward/record.url?scp=0035927929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035927929&partnerID=8YFLogxK
U2 - 10.1016/S0300-483X(01)00384-5
DO - 10.1016/S0300-483X(01)00384-5
M3 - Article
C2 - 11516519
AN - SCOPUS:0035927929
VL - 163
SP - 101
EP - 105
JO - Toxicology
JF - Toxicology
SN - 0300-483X
IS - 2-3
ER -