Comparative studies on the efficacy of AmBisome and Fungizone in a mouse model of disseminated aspergillosis

Koji Takemoto, Yutaka Yamamoto, Yutaka Ueda, Yoshihiro Sumita, Koichiro Yoshida, Yoshihito Niki

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Objectives: The efficacy of intravenous injections of a liposomal formulation of amphotericin B (AmBisome) and amphotericin B deoxycholate (Fungizone) was evaluated in immunocompetent and temporarily leucopenic mouse models of disseminated aspergillosis using seven isolates of Aspergillus. Methods: Mice were infected with the organisms via tail veins. At 4 h after infection, antifungals were administered intravenously. For 30 days the number of mice surviving was recorded. Results: AmBisome at 1 mg/kg or higher significantly prolonged the survival time of mice infected with five out of seven isolates of Aspergillus compared with the control group. There was no difference in in vivo activity between AmBisome and Fungizone at 1 mg/kg in six isolates of Aspergillus. At the maximum tolerated dose of antifungals, however, AmBisome (10 mg/kg) showed greater efficacy than Fungizone (1 mg/kg). Conclusions: These results suggest that the overall protective activity of AmBisome against disseminated aspergillosis is superior to that of Fungizone.

Original languageEnglish
Pages (from-to)311-317
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Volume53
Issue number2
DOIs
Publication statusPublished - Feb 1 2004

Keywords

  • Amphotericin B deoxycholate
  • Aspergillus
  • Liposomal amphotericin B
  • Tolerability

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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