Comparative examination of subcutaneous tissue reaction to high molecular materials in medical use

M. Tomida, Keisuke Nakano, S. Matsuura, Toshiyuki Kawakami

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Polypropylene (PP), Polyethylene (PE) and polytetra-fluoroethylene (FE) are high molecular materials in medical use. They are also used as the negative control materials for ISO 10993-6 international standard biological evaluation of medical devices. We examined tissue reactions to these materials embedded subcutaneously in the dorsal area of male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding site was removed and then histopathological examination was performed. Our results demonstrate that the basic histopathological reaction is the formation of fibrous capsule consisting of granulation tissue around the embedded materials. Based on our results, we believe that the high molecular materials such as, PP, PE and FE, can be considered for medical use as a biomaterials within the body.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalEuropean Journal of Medical Research
Volume16
Issue number6
Publication statusPublished - Jun 21 2011
Externally publishedYes

Fingerprint

Polypropylenes
Subcutaneous Tissue
Polyethylene
Tissue Embedding
Granulation Tissue
Biocompatible Materials
Capsules
Equipment and Supplies
vinyl fluoride

Keywords

  • High molecular material
  • Histopathological evaluation
  • Tissue reaction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Comparative examination of subcutaneous tissue reaction to high molecular materials in medical use. / Tomida, M.; Nakano, Keisuke; Matsuura, S.; Kawakami, Toshiyuki.

In: European Journal of Medical Research, Vol. 16, No. 6, 21.06.2011, p. 249-252.

Research output: Contribution to journalArticle

@article{5a3f153c7ad1406596562e7a2a53f253,
title = "Comparative examination of subcutaneous tissue reaction to high molecular materials in medical use",
abstract = "Polypropylene (PP), Polyethylene (PE) and polytetra-fluoroethylene (FE) are high molecular materials in medical use. They are also used as the negative control materials for ISO 10993-6 international standard biological evaluation of medical devices. We examined tissue reactions to these materials embedded subcutaneously in the dorsal area of male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding site was removed and then histopathological examination was performed. Our results demonstrate that the basic histopathological reaction is the formation of fibrous capsule consisting of granulation tissue around the embedded materials. Based on our results, we believe that the high molecular materials such as, PP, PE and FE, can be considered for medical use as a biomaterials within the body.",
keywords = "High molecular material, Histopathological evaluation, Tissue reaction",
author = "M. Tomida and Keisuke Nakano and S. Matsuura and Toshiyuki Kawakami",
year = "2011",
month = "6",
day = "21",
language = "English",
volume = "16",
pages = "249--252",
journal = "European Journal of Medical Research",
issn = "0949-2321",
publisher = "BioMed Central",
number = "6",

}

TY - JOUR

T1 - Comparative examination of subcutaneous tissue reaction to high molecular materials in medical use

AU - Tomida, M.

AU - Nakano, Keisuke

AU - Matsuura, S.

AU - Kawakami, Toshiyuki

PY - 2011/6/21

Y1 - 2011/6/21

N2 - Polypropylene (PP), Polyethylene (PE) and polytetra-fluoroethylene (FE) are high molecular materials in medical use. They are also used as the negative control materials for ISO 10993-6 international standard biological evaluation of medical devices. We examined tissue reactions to these materials embedded subcutaneously in the dorsal area of male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding site was removed and then histopathological examination was performed. Our results demonstrate that the basic histopathological reaction is the formation of fibrous capsule consisting of granulation tissue around the embedded materials. Based on our results, we believe that the high molecular materials such as, PP, PE and FE, can be considered for medical use as a biomaterials within the body.

AB - Polypropylene (PP), Polyethylene (PE) and polytetra-fluoroethylene (FE) are high molecular materials in medical use. They are also used as the negative control materials for ISO 10993-6 international standard biological evaluation of medical devices. We examined tissue reactions to these materials embedded subcutaneously in the dorsal area of male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding site was removed and then histopathological examination was performed. Our results demonstrate that the basic histopathological reaction is the formation of fibrous capsule consisting of granulation tissue around the embedded materials. Based on our results, we believe that the high molecular materials such as, PP, PE and FE, can be considered for medical use as a biomaterials within the body.

KW - High molecular material

KW - Histopathological evaluation

KW - Tissue reaction

UR - http://www.scopus.com/inward/record.url?scp=79960242128&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960242128&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 249

EP - 252

JO - European Journal of Medical Research

JF - European Journal of Medical Research

SN - 0949-2321

IS - 6

ER -