Comparative examination of subcutaneous tissue reaction to high molecular materials in medical use

M. Tomida, K. Nakano, S. Matsuura, Toshiyuki Kawakami

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Polypropylene (PP), Polyethylene (PE) and polytetra-fluoroethylene (FE) are high molecular materials in medical use. They are also used as the negative control materials for ISO 10993-6 international standard biological evaluation of medical devices. We examined tissue reactions to these materials embedded subcutaneously in the dorsal area of male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding site was removed and then histopathological examination was performed. Our results demonstrate that the basic histopathological reaction is the formation of fibrous capsule consisting of granulation tissue around the embedded materials. Based on our results, we believe that the high molecular materials such as, PP, PE and FE, can be considered for medical use as a biomaterials within the body.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalEuropean journal of medical research
Volume16
Issue number6
DOIs
Publication statusPublished - Jun 21 2011

Keywords

  • High molecular material
  • Histopathological evaluation
  • Tissue reaction

ASJC Scopus subject areas

  • Medicine(all)

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