Abstract
Polypropylene (PP), Polyethylene (PE) and polytetra-fluoroethylene (FE) are high molecular materials in medical use. They are also used as the negative control materials for ISO 10993-6 international standard biological evaluation of medical devices. We examined tissue reactions to these materials embedded subcutaneously in the dorsal area of male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding site was removed and then histopathological examination was performed. Our results demonstrate that the basic histopathological reaction is the formation of fibrous capsule consisting of granulation tissue around the embedded materials. Based on our results, we believe that the high molecular materials such as, PP, PE and FE, can be considered for medical use as a biomaterials within the body.
| Original language | English |
|---|---|
| Pages (from-to) | 249-252 |
| Number of pages | 4 |
| Journal | European Journal of Medical Research |
| Volume | 16 |
| Issue number | 6 |
| Publication status | Published - Jun 21 2011 |
| Externally published | Yes |
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Keywords
- High molecular material
- Histopathological evaluation
- Tissue reaction
ASJC Scopus subject areas
- Medicine(all)
Cite this
Comparative examination of subcutaneous tissue reaction to high molecular materials in medical use. / Tomida, M.; Nakano, Keisuke; Matsuura, S.; Kawakami, Toshiyuki.
In: European Journal of Medical Research, Vol. 16, No. 6, 21.06.2011, p. 249-252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparative examination of subcutaneous tissue reaction to high molecular materials in medical use
AU - Tomida, M.
AU - Nakano, Keisuke
AU - Matsuura, S.
AU - Kawakami, Toshiyuki
PY - 2011/6/21
Y1 - 2011/6/21
N2 - Polypropylene (PP), Polyethylene (PE) and polytetra-fluoroethylene (FE) are high molecular materials in medical use. They are also used as the negative control materials for ISO 10993-6 international standard biological evaluation of medical devices. We examined tissue reactions to these materials embedded subcutaneously in the dorsal area of male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding site was removed and then histopathological examination was performed. Our results demonstrate that the basic histopathological reaction is the formation of fibrous capsule consisting of granulation tissue around the embedded materials. Based on our results, we believe that the high molecular materials such as, PP, PE and FE, can be considered for medical use as a biomaterials within the body.
AB - Polypropylene (PP), Polyethylene (PE) and polytetra-fluoroethylene (FE) are high molecular materials in medical use. They are also used as the negative control materials for ISO 10993-6 international standard biological evaluation of medical devices. We examined tissue reactions to these materials embedded subcutaneously in the dorsal area of male ddY mice. One week and 12 weeks after embedding, the tissue surrounding the embedding site was removed and then histopathological examination was performed. Our results demonstrate that the basic histopathological reaction is the formation of fibrous capsule consisting of granulation tissue around the embedded materials. Based on our results, we believe that the high molecular materials such as, PP, PE and FE, can be considered for medical use as a biomaterials within the body.
KW - High molecular material
KW - Histopathological evaluation
KW - Tissue reaction
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UR - http://www.scopus.com/inward/citedby.url?scp=79960242128&partnerID=8YFLogxK
M3 - Article
VL - 16
SP - 249
EP - 252
JO - European Journal of Medical Research
JF - European Journal of Medical Research
SN - 0949-2321
IS - 6
ER -