Comparative effects of valsartan in combination with cilnidipine or amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats

Kai Nagasawa, Keiji Takahashi, Natsumi Matsuura, Miwa Takatsu, Takuya Hattori, Shogo Watanabe, Eri Harada, Kazumi Niinuma, Toyoaki Murohara, Kohzo Nagata

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Angiotensin receptor blockers (ARBs) are often supplemented with calcium channel blockers (CCBs) for treatment of hypertension. We recently showed that the L/N-type CCB cilnidipine has superior cardioprotective effects compared with the L-type CCB amlodipine in Dahl salt-sensitive (DS) rats. We have now compared the effects of the ARB valsartan combined with cilnidipine or amlodipine on cardiac pathophysiology in DS rats. DS rats fed a high-salt diet from 6 weeks of age were treated with vehicle, valsartan alone (10 mg kg-1 per day), or valsartan combined with either cilnidipine (1 mg kg-1 per day) or amlodipine (1 mg kg-1 per day) from 7 to 11 weeks. The salt-induced increase in systolic blood pressure apparent in the vehicle group was attenuated similarly in the three drug treatment groups. Valsartan-cilnidipine attenuated left ventricular (LV) fibrosis and diastolic dysfunction as well as cardiac oxidative stress and inflammation to a greater extent than did valsartan alone or valsartan-amlodipine. In addition, the increases in urinary excretion of dopamine and epinephrine as well as in cardiac renin-angiotensin-aldosterone-system (RAAS) gene expression apparent in vehicle-treated rats were attenuated to a greater extent by valsartan-cilnidipine than by the other two treatments. Valsartan-cilnidipine thus attenuated LV remodeling and diastolic dysfunction more effectively than did valsartan or valsartan-amlodipine in rats with salt-sensitive hypertension, and this superior cardioprotective action of valsartan-cilnidipine compared with valsartan-amlodipine is likely attributable, at least in part, to the greater antioxidant and antiinflammatory effects associated with both greater inhibition of cardiac RAAS gene expression and N-type calcium channel blockade.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalHypertension Research
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 8 2015
Externally publishedYes

Fingerprint

Valsartan
Inbred Dahl Rats
Amlodipine
Calcium Channel Blockers
N-Type Calcium Channels
L-Type Calcium Channels
Salts
Angiotensin Receptor Antagonists
Renin-Angiotensin System
Blood Pressure
Hypertension
Gene Expression
cilnidipine
Ventricular Remodeling

Keywords

  • angiotensin receptor blocker
  • calcium channel blocker
  • cardiac remodeling
  • diastolic function

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Comparative effects of valsartan in combination with cilnidipine or amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats. / Nagasawa, Kai; Takahashi, Keiji; Matsuura, Natsumi; Takatsu, Miwa; Hattori, Takuya; Watanabe, Shogo; Harada, Eri; Niinuma, Kazumi; Murohara, Toyoaki; Nagata, Kohzo.

In: Hypertension Research, Vol. 38, No. 1, 08.01.2015, p. 39-47.

Research output: Contribution to journalArticle

Nagasawa, K, Takahashi, K, Matsuura, N, Takatsu, M, Hattori, T, Watanabe, S, Harada, E, Niinuma, K, Murohara, T & Nagata, K 2015, 'Comparative effects of valsartan in combination with cilnidipine or amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats', Hypertension Research, vol. 38, no. 1, pp. 39-47. https://doi.org/10.1038/hr.2014.136
Nagasawa, Kai ; Takahashi, Keiji ; Matsuura, Natsumi ; Takatsu, Miwa ; Hattori, Takuya ; Watanabe, Shogo ; Harada, Eri ; Niinuma, Kazumi ; Murohara, Toyoaki ; Nagata, Kohzo. / Comparative effects of valsartan in combination with cilnidipine or amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats. In: Hypertension Research. 2015 ; Vol. 38, No. 1. pp. 39-47.
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