Comparative cytoskeletal analyses of the inner ear in man and the squirrel monkey

Kazunori Nishizaki, Shin Ichi Usami, M. Anniko, W. Arnold

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Serially sectioned human and squirrel monkey labyrinths were analyzed with high-resolution light microscopy after using 25 different monoclonal antibodies (mAbs) identifying all three main classes of cytoskeletal proteins. A high degree of similarity was found in labyrinths from man and squirrel monkey. Only 1 of 25 mAbs stained differently between the two species. In the squirrel monkey but not in the human the mAbs identifying S-100 proteins stained subpopulations of type I vestibular hair cells in the striola of the two macula and the summit of the cristae as compared to the same type of hair cells in the periphery of vestibular organs. Such an establishment of subpopulations of hair cells with the same ultrastructure has previously not been described in higher vertebrates. In contrast to the species differences in the distribution of neuroactive substances, the cytoskeletal architecture seems to be relatively unchanged and stable during evolution. Since each species has its own hearing and equilibrium function, neurotransmitters (neuropeptides, amino acids, etc.) could contribute to such species-specific functions.

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalORL
Volume57
Issue number2
DOIs
Publication statusPublished - 1995

Fingerprint

Saimiri
Inner Ear
Monoclonal Antibodies
Vestibular Hair Cells
Cytoskeletal Proteins
S100 Proteins
Neuropeptides
Hearing
Neurotransmitter Agents
Vertebrates
Microscopy
Light
Amino Acids

Keywords

  • Actin
  • Calcium
  • Cytoskeleton
  • Hair cells
  • Human
  • Immunomorphology
  • Intermediate filaments
  • Labyrinth
  • Microtubules
  • Squirrel monkey

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Comparative cytoskeletal analyses of the inner ear in man and the squirrel monkey. / Nishizaki, Kazunori; Usami, Shin Ichi; Anniko, M.; Arnold, W.

In: ORL, Vol. 57, No. 2, 1995, p. 87-93.

Research output: Contribution to journalArticle

Nishizaki, Kazunori ; Usami, Shin Ichi ; Anniko, M. ; Arnold, W. / Comparative cytoskeletal analyses of the inner ear in man and the squirrel monkey. In: ORL. 1995 ; Vol. 57, No. 2. pp. 87-93.
@article{63f84e47855c4d04815974576b8ecda4,
title = "Comparative cytoskeletal analyses of the inner ear in man and the squirrel monkey",
abstract = "Serially sectioned human and squirrel monkey labyrinths were analyzed with high-resolution light microscopy after using 25 different monoclonal antibodies (mAbs) identifying all three main classes of cytoskeletal proteins. A high degree of similarity was found in labyrinths from man and squirrel monkey. Only 1 of 25 mAbs stained differently between the two species. In the squirrel monkey but not in the human the mAbs identifying S-100 proteins stained subpopulations of type I vestibular hair cells in the striola of the two macula and the summit of the cristae as compared to the same type of hair cells in the periphery of vestibular organs. Such an establishment of subpopulations of hair cells with the same ultrastructure has previously not been described in higher vertebrates. In contrast to the species differences in the distribution of neuroactive substances, the cytoskeletal architecture seems to be relatively unchanged and stable during evolution. Since each species has its own hearing and equilibrium function, neurotransmitters (neuropeptides, amino acids, etc.) could contribute to such species-specific functions.",
keywords = "Actin, Calcium, Cytoskeleton, Hair cells, Human, Immunomorphology, Intermediate filaments, Labyrinth, Microtubules, Squirrel monkey",
author = "Kazunori Nishizaki and Usami, {Shin Ichi} and M. Anniko and W. Arnold",
year = "1995",
doi = "10.1159/000276717",
language = "English",
volume = "57",
pages = "87--93",
journal = "ORL; journal for oto-rhino-laryngology and its related specialties",
issn = "0301-1569",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Comparative cytoskeletal analyses of the inner ear in man and the squirrel monkey

AU - Nishizaki, Kazunori

AU - Usami, Shin Ichi

AU - Anniko, M.

AU - Arnold, W.

PY - 1995

Y1 - 1995

N2 - Serially sectioned human and squirrel monkey labyrinths were analyzed with high-resolution light microscopy after using 25 different monoclonal antibodies (mAbs) identifying all three main classes of cytoskeletal proteins. A high degree of similarity was found in labyrinths from man and squirrel monkey. Only 1 of 25 mAbs stained differently between the two species. In the squirrel monkey but not in the human the mAbs identifying S-100 proteins stained subpopulations of type I vestibular hair cells in the striola of the two macula and the summit of the cristae as compared to the same type of hair cells in the periphery of vestibular organs. Such an establishment of subpopulations of hair cells with the same ultrastructure has previously not been described in higher vertebrates. In contrast to the species differences in the distribution of neuroactive substances, the cytoskeletal architecture seems to be relatively unchanged and stable during evolution. Since each species has its own hearing and equilibrium function, neurotransmitters (neuropeptides, amino acids, etc.) could contribute to such species-specific functions.

AB - Serially sectioned human and squirrel monkey labyrinths were analyzed with high-resolution light microscopy after using 25 different monoclonal antibodies (mAbs) identifying all three main classes of cytoskeletal proteins. A high degree of similarity was found in labyrinths from man and squirrel monkey. Only 1 of 25 mAbs stained differently between the two species. In the squirrel monkey but not in the human the mAbs identifying S-100 proteins stained subpopulations of type I vestibular hair cells in the striola of the two macula and the summit of the cristae as compared to the same type of hair cells in the periphery of vestibular organs. Such an establishment of subpopulations of hair cells with the same ultrastructure has previously not been described in higher vertebrates. In contrast to the species differences in the distribution of neuroactive substances, the cytoskeletal architecture seems to be relatively unchanged and stable during evolution. Since each species has its own hearing and equilibrium function, neurotransmitters (neuropeptides, amino acids, etc.) could contribute to such species-specific functions.

KW - Actin

KW - Calcium

KW - Cytoskeleton

KW - Hair cells

KW - Human

KW - Immunomorphology

KW - Intermediate filaments

KW - Labyrinth

KW - Microtubules

KW - Squirrel monkey

UR - http://www.scopus.com/inward/record.url?scp=0028925603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028925603&partnerID=8YFLogxK

U2 - 10.1159/000276717

DO - 10.1159/000276717

M3 - Article

C2 - 7731662

AN - SCOPUS:0028925603

VL - 57

SP - 87

EP - 93

JO - ORL; journal for oto-rhino-laryngology and its related specialties

JF - ORL; journal for oto-rhino-laryngology and its related specialties

SN - 0301-1569

IS - 2

ER -