Comorbidity as predictor poor prognosis for patients with advanced head and neck cancer treated with major surgery

Go Omura, Mizuo Ando, Yuki Saito, Kenya Kobayashi, Tatsuya Yamasoba, Takahiro Asakage

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Background The impact of comorbidities on patients with advanced head and neck cancer treated with major surgery has not been reported before. Methods We retrospectively reviewed clinical charts between 2004 and 2011 at our institution and identified 185 patients with clinical stage III to IV head and neck cancer treated with major surgery. Comorbidities were scored using the Adult Comorbidity Evaluation-27 (ACE-27) index manual. Results Patients with ACE-27 ≥2 had significantly worse overall survival (OS) and disease-specific survival (DSS) than those with ACE-27 ≤1 (p <.0001 and p =.0047, respectively). Multivariate analyses revealed that ACE-27 ≥2 and extracapsular spread (ECS) were independently significant adverse prognostic factors for OS and DSS. In addition, patients with ACE-27 ≥2 had a higher incidence of distant metastases (p =.0057). Conclusion The current study suggests that comorbidities may predict poor prognosis and development of distant metastases for patients with advanced head and neck cancer treated with major surgery.

Original languageEnglish
Pages (from-to)364-369
Number of pages6
JournalHead and Neck
Volume38
Issue number3
DOIs
Publication statusPublished - Mar 1 2016
Externally publishedYes

Keywords

  • Adult Comorbidity Index-27 (ACE-27)
  • advanced head and neck cancer
  • comorbidity
  • prognostic factor
  • radical surgery

ASJC Scopus subject areas

  • Otorhinolaryngology

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