Combined effects of radon inhalation and antioxidant vitamin administration on acute alcohol-induced hepatopathy in mice

Reo Etani, Takahiro Kataoka, Yuichi Nishiyama, Yuji Takata, Kiyonori Yamaoka

Research output: Contribution to journalArticle

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Abstract

It has been reported that radon inhalation activates antioxidative functions in liver and has an antioxidative effect against hepatopathy similar to that of the antioxidative effects of ascorbic acid (VC) or α-tocopherol (VE). In this study, we examined the combined effects of radon inhalation and antioxidant vitamin administration on acute alcohol-induced hepatopathy in mice. ICR mice were subjected to intraperitoneal (i.p.) administration of alcohol after pretreating with air only (sham) or radon at a concentration of approximately 2000 Bq/m3 for 24 hours and i.p. administration of VC (300 mg/kg body weight) or VE (300 mg/kg body weight). In mice injected with alcohol, the combined radon and antioxidant vitamins treatment significantly decreased the activities of glutamic oxaloacetic transaminase in serum compared to not only the alcohol-administered group (sham group), but also the radon inhalation with alcohol administration group or the vitamin and alcohol administration group. In addition, radon inhalation significantly increased the antioxidant level, in such as the catalase activity and the total glutathione content in liver compared to the sham group. These results suggested that the combined radon and antioxidant vitamin treatment could effectively inhibit alcohol-induced hepatopathy in mice without any antagonizing action.

Original languageEnglish
Pages (from-to)1512-1518
Number of pages7
JournalJournal of Nuclear Science and Technology
Volume52
Issue number12
DOIs
Publication statusPublished - Dec 2 2015

Fingerprint

vitamins
Vitamins
Radon
respiration
antioxidants
radon
Antioxidants
mice
alcohols
Alcohols
body weight
liver
Liver
tocopherol
catalase
glutathione
ascorbic acid
Ascorbic acid
serums
air

Keywords

  • alcohol-induced hepatopathy
  • antioxidant vitamin
  • radon inhalation

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering

Cite this

Combined effects of radon inhalation and antioxidant vitamin administration on acute alcohol-induced hepatopathy in mice. / Etani, Reo; Kataoka, Takahiro; Nishiyama, Yuichi; Takata, Yuji; Yamaoka, Kiyonori.

In: Journal of Nuclear Science and Technology, Vol. 52, No. 12, 02.12.2015, p. 1512-1518.

Research output: Contribution to journalArticle

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