Abstract
Spinal cord injury (SCI) causes motor and sensory deficits and is currently considered an incurable disease. We have previously reported that administration of anti-High Mobility Group Box-1 monoclonal antibody (anti-HMGB1 mAb) preserved lesion area and improved locomotion recovery in mouse model of SCI. In order to further enhance the recovery, we here examined combinatorial treatment of anti-HMGB1 mAb and epothilone B (Epo B), which has been reported to promote axon regeneration. This combinatorial treatment significantly increased hindlimb movement compared with anti-HMGB1 mAb alone, although Epo B alone failed to increase functional recovery. These results are in agreement with that anti-HMGB1 mAb alone was able to decrease the lesion area spreading and increase the surviving neuron numbers around the lesion, whereas Epo B facilitated axon outgrowth only in combination with anti-HMGB1 mAb, suggesting that anti-HMGB1 mAb-dependent tissue preservation is necessary for Epo B to exhibit its therapeutic effect. Taken together, the combinatorial treatment can be considered as a novel and clinically applicable strategy for SCI.
Original language | English |
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Pages (from-to) | 13-25 |
Number of pages | 13 |
Journal | Neuroscience Research |
Volume | 172 |
DOIs | |
Publication status | Published - Nov 2021 |
Externally published | Yes |
Keywords
- Axon regeneration
- Contusion injury
- Epothilone B
- Functional recovery
- High Mobility Group Box-1
- Spinal cord injury
ASJC Scopus subject areas
- Neuroscience(all)