Combination of zinc and all-trans retinoic acid promotes protection against Listeria monocytogenes infection

Yussaira Castillo, Masato Tachibana, Yukiko Nakatsu, Kenta Watanabe, Takashi Shimizu, Masahisa Watarai

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Zinc (Zn) is the second most abundant transition metal after iron. It plays a vital role in living organisms and affects multiple aspects of the immune system. All-trans retinoic acid (atRA) is an isomeric form of the vitamin A or retinol. It possesses the greatest biological activity of Vitamin A. Vitamin A and related retinoids influence many aspects of immunity. In this study, we demonstrated that treatment with a combination of Zn and atRA contributes to host resistance against infection by Listeria monocytogenes. Pretreatment with Zn and atRA enhanced resistance against L. monocytogenes infection in mice and treatment with both Zn and atRA showed a higher protective effect than treatment with either alone. Supplementation with Zn, atRA or their combination decreased the number of L. monocytogenes present in target organs. In vitro, supplementation increased the bacterial uptake by macrophage cells and reduced the replication of L. monocytogenes. Our results suggest that the combination of Zn and atRA has a great bacteriostatic impact on L. monocytogenes and its infection.

Original languageEnglish
Article numbere0137463
JournalPloS one
Volume10
Issue number9
DOIs
Publication statusPublished - Sep 9 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint Dive into the research topics of 'Combination of zinc and all-trans retinoic acid promotes protection against Listeria monocytogenes infection'. Together they form a unique fingerprint.

  • Cite this

    Castillo, Y., Tachibana, M., Nakatsu, Y., Watanabe, K., Shimizu, T., & Watarai, M. (2015). Combination of zinc and all-trans retinoic acid promotes protection against Listeria monocytogenes infection. PloS one, 10(9), [e0137463]. https://doi.org/10.1371/journal.pone.0137463