Combination chemotherapy with continuous 5-fluorouracil and low-dose cisplatin infusion for advanced hepatocellular carcinoma

Hiroaki Tanioka, Akihito Tsuji, Sojiro Morita, Tadashi Horimi, Masahiro Takamatsu, Tetsuhiko Shirasaka, Takaaki Mizushima, Koji Ochi, Katsuyuki Kiura, Mitsune Tanimoto

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Abstract

Background: In this study we evaluated the efficacy and toxicities of combination chemotherapy consisting of continuous 5-fluorouracil (5-FU) infusion and low-dose cisplatin infusion (low-dose FP therapy) in the treatment of advanced hepatocellular carcinoma (HCC). Materials and Methods: Thirty-eight patients with advanced HCC in whom local treatment was not indicated were enrolled. The low-dose FP therapy consisted of 5-FU (170mg/m2/day on days 1 to 7/week, continuous infusion) and cisplatin (3mg/m2/day in 100ml normal saline, infusion more than 30 minutes, on days 1 to 5/week). The patients were treated for 4 consecutive weeks with a subsequent one-week rest period. Results: Thirty-seven of the 38 patients (97%) completed this therapy. A partial response was obtained in 18 (47%), no change in 10 and progressive disease in 9. The time to progression was 211 days. The most common toxicity was nausea/vomiting (13.2%). Conclusion: Low-dose FP therapy has a substantial effect on low-grade toxicity in long-term treatment. Low-dose FP therapy is useful for the treatment of advanced HCC.

Original languageEnglish
Pages (from-to)1891-1897
Number of pages7
JournalAnticancer research
Volume23
Issue number2 C
Publication statusPublished - Mar 1 2003

Keywords

  • 5-fluorouracil
  • Biochemical modulation
  • Chemotherapy
  • Cisplatin
  • Combination
  • Hepatocellular carcinoma
  • Serum concentration

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Tanioka, H., Tsuji, A., Morita, S., Horimi, T., Takamatsu, M., Shirasaka, T., Mizushima, T., Ochi, K., Kiura, K., & Tanimoto, M. (2003). Combination chemotherapy with continuous 5-fluorouracil and low-dose cisplatin infusion for advanced hepatocellular carcinoma. Anticancer research, 23(2 C), 1891-1897.