Abstract
(Purpose) There is no effective therapy against hormone refractory prostate cancer. This led us to evaluate the effectiveness and toxicity of cis-platinum (CDDP) and ifosfamide (IFM) combination chemotherapy in the patients with hormone-unresponsive carcinoma of the prostate. (Methods) Patients with hormone-unresponsive prostate cancer were scheduled to receive CDDP 70 mg/m2 intravenously on day 1 and IFM 1.2 g/m2/day intravenously on day 1 through day 5 of 28-day cycle. (Results) Twenty seven patients with hormone unresponsive prostate cancer were enrolled onto this trial. Of these patients, seven (26%) demonstrated a partial objective response (PR), and ten (37%) a stable disease (ST). The response duration of PR cases lasted from 6 to 49 months with a median of 16 months and the response duration of PR+ST cases lasted from 3 to 36 months with a median of 10 months. Subjective improvement was obtained in 11 patients (41%). Survival duration of all cases were 4 to 89 months with a median of 23 months and probabilities of survival at 3 years and 5 years were 36% and 24%, respectively. The toxicity of this treatment was mostly mild to moderate, anemia (96%), leukocytopenia (89%), anorexia (81%), alopecia (67%), thrombocytopenia (44%), hematuria (38%), renal dysfunction (19%) and liver dysfunction (7%) were noticed. Severe toxicity was observed in two cases, one acute renal failure and one endotoxin shock. (Conclusion) We conclude that CDDP and IFM combination chemotherapy was active regimen for hormone unresponsive prostate cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 657-664 |
| Number of pages | 8 |
| Journal | Japanese Journal of Urology |
| Volume | 89 |
| Issue number | 7 |
| Publication status | Published - Jul 1998 |
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Keywords
- Chemotherapy
- Hormone refractory
- Prostate cancer
ASJC Scopus subject areas
- Urology
Cite this
Combination chemotherapy with cis-platinum and ifosfamide for hormone unresponsive prostate cancer. / Maki, Yoshio; Tsushima, Tomoyasu; Nasu, Yasutomo; Kumon, Hiromi; Ohmori, Hiroyuki; Tanahashi, Toyoko; Nanba, Katsuichi; Ohashi, Teruhisa; Kondo, Katsuyoshi; Saika, Takashi; Asahi, Toshihiko.
In: Japanese Journal of Urology, Vol. 89, No. 7, 07.1998, p. 657-664.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combination chemotherapy with cis-platinum and ifosfamide for hormone unresponsive prostate cancer
AU - Maki, Yoshio
AU - Tsushima, Tomoyasu
AU - Nasu, Yasutomo
AU - Kumon, Hiromi
AU - Ohmori, Hiroyuki
AU - Tanahashi, Toyoko
AU - Nanba, Katsuichi
AU - Ohashi, Teruhisa
AU - Kondo, Katsuyoshi
AU - Saika, Takashi
AU - Asahi, Toshihiko
PY - 1998/7
Y1 - 1998/7
N2 - (Purpose) There is no effective therapy against hormone refractory prostate cancer. This led us to evaluate the effectiveness and toxicity of cis-platinum (CDDP) and ifosfamide (IFM) combination chemotherapy in the patients with hormone-unresponsive carcinoma of the prostate. (Methods) Patients with hormone-unresponsive prostate cancer were scheduled to receive CDDP 70 mg/m2 intravenously on day 1 and IFM 1.2 g/m2/day intravenously on day 1 through day 5 of 28-day cycle. (Results) Twenty seven patients with hormone unresponsive prostate cancer were enrolled onto this trial. Of these patients, seven (26%) demonstrated a partial objective response (PR), and ten (37%) a stable disease (ST). The response duration of PR cases lasted from 6 to 49 months with a median of 16 months and the response duration of PR+ST cases lasted from 3 to 36 months with a median of 10 months. Subjective improvement was obtained in 11 patients (41%). Survival duration of all cases were 4 to 89 months with a median of 23 months and probabilities of survival at 3 years and 5 years were 36% and 24%, respectively. The toxicity of this treatment was mostly mild to moderate, anemia (96%), leukocytopenia (89%), anorexia (81%), alopecia (67%), thrombocytopenia (44%), hematuria (38%), renal dysfunction (19%) and liver dysfunction (7%) were noticed. Severe toxicity was observed in two cases, one acute renal failure and one endotoxin shock. (Conclusion) We conclude that CDDP and IFM combination chemotherapy was active regimen for hormone unresponsive prostate cancer.
AB - (Purpose) There is no effective therapy against hormone refractory prostate cancer. This led us to evaluate the effectiveness and toxicity of cis-platinum (CDDP) and ifosfamide (IFM) combination chemotherapy in the patients with hormone-unresponsive carcinoma of the prostate. (Methods) Patients with hormone-unresponsive prostate cancer were scheduled to receive CDDP 70 mg/m2 intravenously on day 1 and IFM 1.2 g/m2/day intravenously on day 1 through day 5 of 28-day cycle. (Results) Twenty seven patients with hormone unresponsive prostate cancer were enrolled onto this trial. Of these patients, seven (26%) demonstrated a partial objective response (PR), and ten (37%) a stable disease (ST). The response duration of PR cases lasted from 6 to 49 months with a median of 16 months and the response duration of PR+ST cases lasted from 3 to 36 months with a median of 10 months. Subjective improvement was obtained in 11 patients (41%). Survival duration of all cases were 4 to 89 months with a median of 23 months and probabilities of survival at 3 years and 5 years were 36% and 24%, respectively. The toxicity of this treatment was mostly mild to moderate, anemia (96%), leukocytopenia (89%), anorexia (81%), alopecia (67%), thrombocytopenia (44%), hematuria (38%), renal dysfunction (19%) and liver dysfunction (7%) were noticed. Severe toxicity was observed in two cases, one acute renal failure and one endotoxin shock. (Conclusion) We conclude that CDDP and IFM combination chemotherapy was active regimen for hormone unresponsive prostate cancer.
KW - Chemotherapy
KW - Hormone refractory
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=7344236787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7344236787&partnerID=8YFLogxK
M3 - Article
C2 - 9739587
AN - SCOPUS:7344236787
VL - 89
SP - 657
EP - 664
JO - Japanese Journal of Urology
JF - Japanese Journal of Urology
SN - 0021-5287
IS - 7
ER -