Abstract
Eighteen elderly patients aged 76 years or older with small cell lung cancer were treated with carboplatin (AUC = 4 mg/ml.min, i.v. day 1) and etoposide (70 mg/m2 i.v. day 1-3) and 17 patients were evaluable. The median age of the study population was 77 years (range: 76-81). Eight patients had limited disease (LD) and nine did extensive disease (ED). The overall response rate was 88% for LD patients and 67% for ED patients. Median survival time was 219 days for LD patients and 158 days for ED patients. Grade 3 and 4 leukopenia, neutropenia, thrombocytopenia and anemia occurred in 41%, 76%, 24% and 6% of patients, respectively. There was one treatment-related death due to pneumonitis.
| Original language | English |
|---|---|
| Pages (from-to) | 751-756 |
| Number of pages | 6 |
| Journal | Gan to kagaku ryoho. Cancer & chemotherapy |
| Volume | 29 |
| Issue number | 5 |
| Publication status | Published - May 2002 |
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ASJC Scopus subject areas
- Cancer Research
- Pharmacology
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Combination chemotherapy with carboplatin and etoposide for elderly patients aged 76 years or older with small cell lung cancer. / Tada, Atsuhiko; Ueoka, Hiroshi; Kiura, Katsuyuki; Tabata, Masahiro; Takemoto, Mitsuhiro; Yamane, Hiromichi; Hiyama, Junichiro; Aoe, Keisuke; Shibayama, Takuo; Kamei, Haruhito; Kawahara, Shin; Harita, Shingo; Sato, Toshio; Kobayashi, Makoto; Eguchi, Kenji; Hiraki, Shunkichi; Hiraki, Yoshio; Tanimoto, Mitsune.
In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 29, No. 5, 05.2002, p. 751-756.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Combination chemotherapy with carboplatin and etoposide for elderly patients aged 76 years or older with small cell lung cancer
AU - Tada, Atsuhiko
AU - Ueoka, Hiroshi
AU - Kiura, Katsuyuki
AU - Tabata, Masahiro
AU - Takemoto, Mitsuhiro
AU - Yamane, Hiromichi
AU - Hiyama, Junichiro
AU - Aoe, Keisuke
AU - Shibayama, Takuo
AU - Kamei, Haruhito
AU - Kawahara, Shin
AU - Harita, Shingo
AU - Sato, Toshio
AU - Kobayashi, Makoto
AU - Eguchi, Kenji
AU - Hiraki, Shunkichi
AU - Hiraki, Yoshio
AU - Tanimoto, Mitsune
PY - 2002/5
Y1 - 2002/5
N2 - Eighteen elderly patients aged 76 years or older with small cell lung cancer were treated with carboplatin (AUC = 4 mg/ml.min, i.v. day 1) and etoposide (70 mg/m2 i.v. day 1-3) and 17 patients were evaluable. The median age of the study population was 77 years (range: 76-81). Eight patients had limited disease (LD) and nine did extensive disease (ED). The overall response rate was 88% for LD patients and 67% for ED patients. Median survival time was 219 days for LD patients and 158 days for ED patients. Grade 3 and 4 leukopenia, neutropenia, thrombocytopenia and anemia occurred in 41%, 76%, 24% and 6% of patients, respectively. There was one treatment-related death due to pneumonitis.
AB - Eighteen elderly patients aged 76 years or older with small cell lung cancer were treated with carboplatin (AUC = 4 mg/ml.min, i.v. day 1) and etoposide (70 mg/m2 i.v. day 1-3) and 17 patients were evaluable. The median age of the study population was 77 years (range: 76-81). Eight patients had limited disease (LD) and nine did extensive disease (ED). The overall response rate was 88% for LD patients and 67% for ED patients. Median survival time was 219 days for LD patients and 158 days for ED patients. Grade 3 and 4 leukopenia, neutropenia, thrombocytopenia and anemia occurred in 41%, 76%, 24% and 6% of patients, respectively. There was one treatment-related death due to pneumonitis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036560609&partnerID=8YFLogxK
M3 - Article
VL - 29
SP - 751
EP - 756
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
SN - 0385-0684
IS - 5
ER -