Combination chemotherapy comprising orally administered UFT and leucovorin against a human prostate carcinoma cell line (PC-3) in nude mice

Y. Sumiyoshi, K. Hashine, M. Akiyama, H. Doihara, H. Satake

Research output: Contribution to journalArticle

Abstract

We evaluated the efficacy of combination chemotherapy comprising orally administered UFT (20 mg/kg) with leucovorin (100 mg/kg) against a human prostate carcinoma cell line (PC-3) in nude mice. Our results showed that the combined treatment of UFT and leucovorin against PC-3 was significantly more effective than no therapy, or leucovorin therapy alone (p < 0.1), with only a very small decrease in body-weight being noted in the mice. The histological change of degeneration and/or necrosis was observed in the group receiving the combined therapy. These results suggest that combination chemotherapy comprising UFT with leucovorin may be useful for the treatment of prostatic cancer.

Original languageEnglish
Pages (from-to)857-860
Number of pages4
JournalNishinihon Journal of Urology
Volume56
Issue number8
Publication statusPublished - Jan 1 1994
Externally publishedYes

Keywords

  • UFT
  • biochemical modulation
  • leucovorin
  • prostate carcinoma

ASJC Scopus subject areas

  • Urology

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