Abstract
We evaluated the efficacy of combination chemotherapy comprising orally administered UFT (20 mg/kg) with leucovorin (100 mg/kg) against a human prostate carcinoma cell line (PC-3) in nude mice. Our results showed that the combined treatment of UFT and leucovorin against PC-3 was significantly more effective than no therapy, or leucovorin therapy alone (p <0.1), with only a very small decrease in body-weight being noted in the mice. The histological change of degeneration and/or necrosis was observed in the group receiving the combined therapy. These results suggest that combination chemotherapy comprising UFT with leucovorin may be useful for the treatment of prostatic cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 857-860 |
| Number of pages | 4 |
| Journal | Nishinihon Journal of Urology |
| Volume | 56 |
| Issue number | 8 |
| Publication status | Published - 1994 |
| Externally published | Yes |
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Keywords
- biochemical modulation
- leucovorin
- prostate carcinoma
- UFT
ASJC Scopus subject areas
- Urology
Cite this
Combination chemotherapy comprising orally administered UFT and leucovorin against a human prostate carcinoma cell line (PC-3) in nude mice. / Sumiyoshi, Y.; Hashine, K.; Akiyama, M.; Doihara, Hiroyoshi; Satake, H.
In: Nishinihon Journal of Urology, Vol. 56, No. 8, 1994, p. 857-860.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combination chemotherapy comprising orally administered UFT and leucovorin against a human prostate carcinoma cell line (PC-3) in nude mice
AU - Sumiyoshi, Y.
AU - Hashine, K.
AU - Akiyama, M.
AU - Doihara, Hiroyoshi
AU - Satake, H.
PY - 1994
Y1 - 1994
N2 - We evaluated the efficacy of combination chemotherapy comprising orally administered UFT (20 mg/kg) with leucovorin (100 mg/kg) against a human prostate carcinoma cell line (PC-3) in nude mice. Our results showed that the combined treatment of UFT and leucovorin against PC-3 was significantly more effective than no therapy, or leucovorin therapy alone (p <0.1), with only a very small decrease in body-weight being noted in the mice. The histological change of degeneration and/or necrosis was observed in the group receiving the combined therapy. These results suggest that combination chemotherapy comprising UFT with leucovorin may be useful for the treatment of prostatic cancer.
AB - We evaluated the efficacy of combination chemotherapy comprising orally administered UFT (20 mg/kg) with leucovorin (100 mg/kg) against a human prostate carcinoma cell line (PC-3) in nude mice. Our results showed that the combined treatment of UFT and leucovorin against PC-3 was significantly more effective than no therapy, or leucovorin therapy alone (p <0.1), with only a very small decrease in body-weight being noted in the mice. The histological change of degeneration and/or necrosis was observed in the group receiving the combined therapy. These results suggest that combination chemotherapy comprising UFT with leucovorin may be useful for the treatment of prostatic cancer.
KW - biochemical modulation
KW - leucovorin
KW - prostate carcinoma
KW - UFT
UR - http://www.scopus.com/inward/record.url?scp=0028071585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028071585&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0028071585
VL - 56
SP - 857
EP - 860
JO - Nishinihon Journal of Urology
JF - Nishinihon Journal of Urology
SN - 0029-0726
IS - 8
ER -