Combination benefit of cognitive rehabilitation plus donepezil for Alzheimer's disease patients

Kosuke Matsuzono, Nozomi Hishikawa, Yoshiki Takao, Yosuke Wakutani, Toru Yamashita, Kentaro Deguchi, Koji Abe

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objects: Alzheimer's disease (AD) is one of the most important diseases in aging society, and non-drug therapy might be an alternative therapeutic approach. Thus, we evaluated the add-on effect of cognitive rehabilitation on AD patients under donepezil treatment. Methods: We retrospectively analyzed 55 AD patients with a Mini-Mental State Examination score of 15-25, dividing them into two groups depending on whether they were receiving ambulatory cognitive rehabilitation (group D+R, n=32) or not (group D, n=23) in Kurashiki Heisei Hospital over 1 year. The present cognitive rehabilitation included physical therapy, occupational therapy and speech therapy for 1-2h once or twice a week. Results: Between groupD and groupD+R, there was no significant difference in baseline data, such as age, Mini-Mental State Examination score, periventricular hyperintensity on magnetic resonance imaging, deep white matter hyperintensity on magnetic resonance imaging or donepezil dose (4.1mg/day). At 1 year later, however, the Mini-Mental State Examination score improved only in group D+R from 21.7 to 24.0 (**P

Original languageEnglish
Pages (from-to)200-204
Number of pages5
JournalGeriatrics and Gerontology International
Volume16
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

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dementia
rehabilitation
Alzheimer Disease
Rehabilitation
examination
Group
Magnetic Resonance Imaging
speech therapy
Speech Therapy
occupational therapy
Occupational Therapy
Therapeutics
Disease
donepezil
present

Keywords

  • Alzheimer's disease
  • Cognitive function
  • Cognitive rehabilitation
  • Dementia
  • Donepezil

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology
  • Health(social science)

Cite this

Combination benefit of cognitive rehabilitation plus donepezil for Alzheimer's disease patients. / Matsuzono, Kosuke; Hishikawa, Nozomi; Takao, Yoshiki; Wakutani, Yosuke; Yamashita, Toru; Deguchi, Kentaro; Abe, Koji.

In: Geriatrics and Gerontology International, Vol. 16, No. 2, 01.02.2016, p. 200-204.

Research output: Contribution to journalArticle

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