TY - JOUR
T1 - Combination benefit of cognitive rehabilitation plus donepezil for Alzheimer's disease patients
AU - Matsuzono, Kosuke
AU - Hishikawa, Nozomi
AU - Takao, Yoshiki
AU - Wakutani, Yosuke
AU - Yamashita, Toru
AU - Deguchi, Kentaro
AU - Abe, Koji
N1 - Publisher Copyright:
© 2016 Japan Geriatrics Society.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Objects: Alzheimer's disease (AD) is one of the most important diseases in aging society, and non-drug therapy might be an alternative therapeutic approach. Thus, we evaluated the add-on effect of cognitive rehabilitation on AD patients under donepezil treatment. Methods: We retrospectively analyzed 55 AD patients with a Mini-Mental State Examination score of 15-25, dividing them into two groups depending on whether they were receiving ambulatory cognitive rehabilitation (group D+R, n=32) or not (group D, n=23) in Kurashiki Heisei Hospital over 1 year. The present cognitive rehabilitation included physical therapy, occupational therapy and speech therapy for 1-2h once or twice a week. Results: Between groupD and groupD+R, there was no significant difference in baseline data, such as age, Mini-Mental State Examination score, periventricular hyperintensity on magnetic resonance imaging, deep white matter hyperintensity on magnetic resonance imaging or donepezil dose (4.1mg/day). At 1 year later, however, the Mini-Mental State Examination score improved only in group D+R from 21.7 to 24.0 (**P<0.001), whereas that of groupD remained at 21.5 with both groups of donepezil 5.0mg/day. Conclusion: The combination of cognitive rehabilitation plus a choline esterase inhibitor donepezil showed a better effect for the cognitive function of AD patients than drug only therapy at 1 year.
AB - Objects: Alzheimer's disease (AD) is one of the most important diseases in aging society, and non-drug therapy might be an alternative therapeutic approach. Thus, we evaluated the add-on effect of cognitive rehabilitation on AD patients under donepezil treatment. Methods: We retrospectively analyzed 55 AD patients with a Mini-Mental State Examination score of 15-25, dividing them into two groups depending on whether they were receiving ambulatory cognitive rehabilitation (group D+R, n=32) or not (group D, n=23) in Kurashiki Heisei Hospital over 1 year. The present cognitive rehabilitation included physical therapy, occupational therapy and speech therapy for 1-2h once or twice a week. Results: Between groupD and groupD+R, there was no significant difference in baseline data, such as age, Mini-Mental State Examination score, periventricular hyperintensity on magnetic resonance imaging, deep white matter hyperintensity on magnetic resonance imaging or donepezil dose (4.1mg/day). At 1 year later, however, the Mini-Mental State Examination score improved only in group D+R from 21.7 to 24.0 (**P<0.001), whereas that of groupD remained at 21.5 with both groups of donepezil 5.0mg/day. Conclusion: The combination of cognitive rehabilitation plus a choline esterase inhibitor donepezil showed a better effect for the cognitive function of AD patients than drug only therapy at 1 year.
KW - Alzheimer's disease
KW - Cognitive function
KW - Cognitive rehabilitation
KW - Dementia
KW - Donepezil
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U2 - 10.1111/ggi.12455
DO - 10.1111/ggi.12455
M3 - Article
C2 - 25656634
AN - SCOPUS:84956794395
VL - 16
SP - 200
EP - 204
JO - Geriatrics and Gerontology International
JF - Geriatrics and Gerontology International
SN - 1447-0594
IS - 2
ER -