Abstract
Objects: Alzheimer's disease (AD) is one of the most important diseases in aging society, and non-drug therapy might be an alternative therapeutic approach. Thus, we evaluated the add-on effect of cognitive rehabilitation on AD patients under donepezil treatment. Methods: We retrospectively analyzed 55 AD patients with a Mini-Mental State Examination score of 15-25, dividing them into two groups depending on whether they were receiving ambulatory cognitive rehabilitation (group D+R, n=32) or not (group D, n=23) in Kurashiki Heisei Hospital over 1 year. The present cognitive rehabilitation included physical therapy, occupational therapy and speech therapy for 1-2h once or twice a week. Results: Between groupD and groupD+R, there was no significant difference in baseline data, such as age, Mini-Mental State Examination score, periventricular hyperintensity on magnetic resonance imaging, deep white matter hyperintensity on magnetic resonance imaging or donepezil dose (4.1mg/day). At 1 year later, however, the Mini-Mental State Examination score improved only in group D+R from 21.7 to 24.0 (**P
| Original language | English |
|---|---|
| Pages (from-to) | 200-204 |
| Number of pages | 5 |
| Journal | Geriatrics and Gerontology International |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2016 |
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Keywords
- Alzheimer's disease
- Cognitive function
- Cognitive rehabilitation
- Dementia
- Donepezil
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Gerontology
- Health(social science)
Cite this
Combination benefit of cognitive rehabilitation plus donepezil for Alzheimer's disease patients. / Matsuzono, Kosuke; Hishikawa, Nozomi; Takao, Yoshiki; Wakutani, Yosuke; Yamashita, Toru; Deguchi, Kentaro; Abe, Koji.
In: Geriatrics and Gerontology International, Vol. 16, No. 2, 01.02.2016, p. 200-204.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combination benefit of cognitive rehabilitation plus donepezil for Alzheimer's disease patients
AU - Matsuzono, Kosuke
AU - Hishikawa, Nozomi
AU - Takao, Yoshiki
AU - Wakutani, Yosuke
AU - Yamashita, Toru
AU - Deguchi, Kentaro
AU - Abe, Koji
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Objects: Alzheimer's disease (AD) is one of the most important diseases in aging society, and non-drug therapy might be an alternative therapeutic approach. Thus, we evaluated the add-on effect of cognitive rehabilitation on AD patients under donepezil treatment. Methods: We retrospectively analyzed 55 AD patients with a Mini-Mental State Examination score of 15-25, dividing them into two groups depending on whether they were receiving ambulatory cognitive rehabilitation (group D+R, n=32) or not (group D, n=23) in Kurashiki Heisei Hospital over 1 year. The present cognitive rehabilitation included physical therapy, occupational therapy and speech therapy for 1-2h once or twice a week. Results: Between groupD and groupD+R, there was no significant difference in baseline data, such as age, Mini-Mental State Examination score, periventricular hyperintensity on magnetic resonance imaging, deep white matter hyperintensity on magnetic resonance imaging or donepezil dose (4.1mg/day). At 1 year later, however, the Mini-Mental State Examination score improved only in group D+R from 21.7 to 24.0 (**P
AB - Objects: Alzheimer's disease (AD) is one of the most important diseases in aging society, and non-drug therapy might be an alternative therapeutic approach. Thus, we evaluated the add-on effect of cognitive rehabilitation on AD patients under donepezil treatment. Methods: We retrospectively analyzed 55 AD patients with a Mini-Mental State Examination score of 15-25, dividing them into two groups depending on whether they were receiving ambulatory cognitive rehabilitation (group D+R, n=32) or not (group D, n=23) in Kurashiki Heisei Hospital over 1 year. The present cognitive rehabilitation included physical therapy, occupational therapy and speech therapy for 1-2h once or twice a week. Results: Between groupD and groupD+R, there was no significant difference in baseline data, such as age, Mini-Mental State Examination score, periventricular hyperintensity on magnetic resonance imaging, deep white matter hyperintensity on magnetic resonance imaging or donepezil dose (4.1mg/day). At 1 year later, however, the Mini-Mental State Examination score improved only in group D+R from 21.7 to 24.0 (**P
KW - Alzheimer's disease
KW - Cognitive function
KW - Cognitive rehabilitation
KW - Dementia
KW - Donepezil
UR - http://www.scopus.com/inward/record.url?scp=84956794395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84956794395&partnerID=8YFLogxK
U2 - 10.1111/ggi.12455
DO - 10.1111/ggi.12455
M3 - Article
C2 - 25656634
AN - SCOPUS:84956794395
VL - 16
SP - 200
EP - 204
JO - Geriatrics and Gerontology International
JF - Geriatrics and Gerontology International
SN - 1447-0594
IS - 2
ER -