Colopsinol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp.

Jun'ichi Kobayashi, Takaaki Kubota, Miho Takahashi, Masami Ishibashi, Masashi Tsuda, Hideo Naoki

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Colopsinol A (1), a novel polyhydroxyl compound, has been isolated from the cultured marine dinoflagellate Amphidinium sp., from which a number of cytotoxic macrolides, amphidinolides, have been obtained to date, and the gross structure of 1 was elucidated on the basis of extensive spectroscopic analyses including recent 2D NMR techniques of CH2-selected editing HSQC as well as FABMS/MS experiments and chemical means. Colopsinol A (1), C71H119O25SNa, is the first member of a new class of polyketide natural products possessing a gentiobioside moiety and a sulfate ester. The polyketide aglycon consisted of a C56-linear aliphatic chain with one exo- methylene and two methyl branches as well as two ketones, five hydroxyl groups, and a tetrahydropyran and two epoxide rings.

Original languageEnglish
Pages (from-to)1478-1482
Number of pages5
JournalJournal of Organic Chemistry
Volume64
Issue number5
DOIs
Publication statusPublished - Mar 5 1999
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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