Colocalization of tracks from boron neutron capture reactions and images of isolated cells

Ian Postuma, Patrizia Sommi, Agostina Vitali, Diyun Shu, Greta di Martino, Laura Cansolino, Cinzia Ferrari, Vittorio Ricci, Chiara Magni, Nicoletta Protti, Setareh Fatemi, Umberto Anselmi Tamburini, Silva Bortolussi, Saverio Altieri

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In Boron Neutron Capture Therapy, the boronated drug plays a leading role in delivering a lethal dose to the tumour. The effectiveness depends on the boron macroscopic concentration and on its distribution at sub-cellular level. This work shows a way to colocalize alpha particles and lithium ions tracks with cells. A neutron autoradiography technique is used, which combines images of cells with images of tracks produced in a solid-state nuclear track detector.

Original languageEnglish
Article number109353
JournalApplied Radiation and Isotopes
Volume167
DOIs
Publication statusPublished - Jan 2021
Externally publishedYes

Keywords

  • BNCT
  • Boron
  • Cell cultures
  • Neutron autoradiography

ASJC Scopus subject areas

  • Radiation

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