Cognitive functions in Parkinson's disease: Relation to disease severity and hallucination

Takaaki Wakamori, Takashi Agari, Takao Yasuhara, Masahiro Kameda, Akihiko Kondo, Aiko Shinko, Susumu Sasada, Tatsuya Sasaki, Tomohisa Furuta, Isao Date

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: We wished to relate severity of Parkinson's disease (PD) with cognitive function in relation to cerebral blood flow (CBF). Methods: Eighty-one consecutive PD patients were enrolled in this study. We used Mini-Mental State Examination (MMSE) and Wechsler Adult Intelligence Scale-Third edition (WAIS-III) to evaluate cognitive functions, and three-dimensional stereotactic ROI template (3DSRT) and Statistical Parametric Mapping (SPM) 8 to evaluate single photon emission CT (SPECT) recordings of regional CBF. Results: The mean MMSE score of PD patients was 27.4±2.4. The scores of most patients were higher than 23/30. On the other hand, the mean Full-scale IQ of PD patients was 88.4±17.3 in WAIS-III, which was lower than that of normal controls. In particular, visuospatial function score of most patients was lower. There was significant correlation between cognitive scores and Hoehn & Yahr stage and hallucinatory episodes. PD Patients with stage III and IV showed significant deterioration in cognitive functions compared to stage II patients. Analysis of CBF revealed relative reductions in perfusion in the cerebral cortex relative to that in normal control. SPM 8 showed that cognitive functions in PD patients were positively correlated with rCBF in the thalamus and cingulate gyrus. Conclusions: This is the study to demonstrate the cognitive impairments in PD patients using WAIS-III. Visuospatial dysfunction might be caused by decrease in rCBF in the parietal and occipital lobes and dorsolateral prefrontal cortex. The severity of cognitive impairments in PD patients was correlated with disease severity and hallucinatory episodes.

Original languageEnglish
Pages (from-to)415-420
Number of pages6
JournalParkinsonism and Related Disorders
Volume20
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Hallucinations
Cognition
Parkinson Disease
Cerebrovascular Circulation
Intelligence
Occipital Lobe
Parietal Lobe
Gyrus Cinguli
Regional Blood Flow
Prefrontal Cortex
Thalamus
Photons
Cerebral Cortex
Perfusion

Keywords

  • Cognitive functions
  • Disease severity
  • Hallucinations
  • Parkinson's disease
  • SPECT

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Cognitive functions in Parkinson's disease : Relation to disease severity and hallucination. / Wakamori, Takaaki; Agari, Takashi; Yasuhara, Takao; Kameda, Masahiro; Kondo, Akihiko; Shinko, Aiko; Sasada, Susumu; Sasaki, Tatsuya; Furuta, Tomohisa; Date, Isao.

In: Parkinsonism and Related Disorders, Vol. 20, No. 4, 2014, p. 415-420.

Research output: Contribution to journalArticle

Wakamori, Takaaki ; Agari, Takashi ; Yasuhara, Takao ; Kameda, Masahiro ; Kondo, Akihiko ; Shinko, Aiko ; Sasada, Susumu ; Sasaki, Tatsuya ; Furuta, Tomohisa ; Date, Isao. / Cognitive functions in Parkinson's disease : Relation to disease severity and hallucination. In: Parkinsonism and Related Disorders. 2014 ; Vol. 20, No. 4. pp. 415-420.
@article{2a3debdd683c49ef854cd7f4c32031b5,
title = "Cognitive functions in Parkinson's disease: Relation to disease severity and hallucination",
abstract = "Objective: We wished to relate severity of Parkinson's disease (PD) with cognitive function in relation to cerebral blood flow (CBF). Methods: Eighty-one consecutive PD patients were enrolled in this study. We used Mini-Mental State Examination (MMSE) and Wechsler Adult Intelligence Scale-Third edition (WAIS-III) to evaluate cognitive functions, and three-dimensional stereotactic ROI template (3DSRT) and Statistical Parametric Mapping (SPM) 8 to evaluate single photon emission CT (SPECT) recordings of regional CBF. Results: The mean MMSE score of PD patients was 27.4±2.4. The scores of most patients were higher than 23/30. On the other hand, the mean Full-scale IQ of PD patients was 88.4±17.3 in WAIS-III, which was lower than that of normal controls. In particular, visuospatial function score of most patients was lower. There was significant correlation between cognitive scores and Hoehn & Yahr stage and hallucinatory episodes. PD Patients with stage III and IV showed significant deterioration in cognitive functions compared to stage II patients. Analysis of CBF revealed relative reductions in perfusion in the cerebral cortex relative to that in normal control. SPM 8 showed that cognitive functions in PD patients were positively correlated with rCBF in the thalamus and cingulate gyrus. Conclusions: This is the study to demonstrate the cognitive impairments in PD patients using WAIS-III. Visuospatial dysfunction might be caused by decrease in rCBF in the parietal and occipital lobes and dorsolateral prefrontal cortex. The severity of cognitive impairments in PD patients was correlated with disease severity and hallucinatory episodes.",
keywords = "Cognitive functions, Disease severity, Hallucinations, Parkinson's disease, SPECT",
author = "Takaaki Wakamori and Takashi Agari and Takao Yasuhara and Masahiro Kameda and Akihiko Kondo and Aiko Shinko and Susumu Sasada and Tatsuya Sasaki and Tomohisa Furuta and Isao Date",
year = "2014",
doi = "10.1016/j.parkreldis.2014.01.002",
language = "English",
volume = "20",
pages = "415--420",
journal = "Parkinsonism and Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",
number = "4",

}

TY - JOUR

T1 - Cognitive functions in Parkinson's disease

T2 - Relation to disease severity and hallucination

AU - Wakamori, Takaaki

AU - Agari, Takashi

AU - Yasuhara, Takao

AU - Kameda, Masahiro

AU - Kondo, Akihiko

AU - Shinko, Aiko

AU - Sasada, Susumu

AU - Sasaki, Tatsuya

AU - Furuta, Tomohisa

AU - Date, Isao

PY - 2014

Y1 - 2014

N2 - Objective: We wished to relate severity of Parkinson's disease (PD) with cognitive function in relation to cerebral blood flow (CBF). Methods: Eighty-one consecutive PD patients were enrolled in this study. We used Mini-Mental State Examination (MMSE) and Wechsler Adult Intelligence Scale-Third edition (WAIS-III) to evaluate cognitive functions, and three-dimensional stereotactic ROI template (3DSRT) and Statistical Parametric Mapping (SPM) 8 to evaluate single photon emission CT (SPECT) recordings of regional CBF. Results: The mean MMSE score of PD patients was 27.4±2.4. The scores of most patients were higher than 23/30. On the other hand, the mean Full-scale IQ of PD patients was 88.4±17.3 in WAIS-III, which was lower than that of normal controls. In particular, visuospatial function score of most patients was lower. There was significant correlation between cognitive scores and Hoehn & Yahr stage and hallucinatory episodes. PD Patients with stage III and IV showed significant deterioration in cognitive functions compared to stage II patients. Analysis of CBF revealed relative reductions in perfusion in the cerebral cortex relative to that in normal control. SPM 8 showed that cognitive functions in PD patients were positively correlated with rCBF in the thalamus and cingulate gyrus. Conclusions: This is the study to demonstrate the cognitive impairments in PD patients using WAIS-III. Visuospatial dysfunction might be caused by decrease in rCBF in the parietal and occipital lobes and dorsolateral prefrontal cortex. The severity of cognitive impairments in PD patients was correlated with disease severity and hallucinatory episodes.

AB - Objective: We wished to relate severity of Parkinson's disease (PD) with cognitive function in relation to cerebral blood flow (CBF). Methods: Eighty-one consecutive PD patients were enrolled in this study. We used Mini-Mental State Examination (MMSE) and Wechsler Adult Intelligence Scale-Third edition (WAIS-III) to evaluate cognitive functions, and three-dimensional stereotactic ROI template (3DSRT) and Statistical Parametric Mapping (SPM) 8 to evaluate single photon emission CT (SPECT) recordings of regional CBF. Results: The mean MMSE score of PD patients was 27.4±2.4. The scores of most patients were higher than 23/30. On the other hand, the mean Full-scale IQ of PD patients was 88.4±17.3 in WAIS-III, which was lower than that of normal controls. In particular, visuospatial function score of most patients was lower. There was significant correlation between cognitive scores and Hoehn & Yahr stage and hallucinatory episodes. PD Patients with stage III and IV showed significant deterioration in cognitive functions compared to stage II patients. Analysis of CBF revealed relative reductions in perfusion in the cerebral cortex relative to that in normal control. SPM 8 showed that cognitive functions in PD patients were positively correlated with rCBF in the thalamus and cingulate gyrus. Conclusions: This is the study to demonstrate the cognitive impairments in PD patients using WAIS-III. Visuospatial dysfunction might be caused by decrease in rCBF in the parietal and occipital lobes and dorsolateral prefrontal cortex. The severity of cognitive impairments in PD patients was correlated with disease severity and hallucinatory episodes.

KW - Cognitive functions

KW - Disease severity

KW - Hallucinations

KW - Parkinson's disease

KW - SPECT

UR - http://www.scopus.com/inward/record.url?scp=84897960405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897960405&partnerID=8YFLogxK

U2 - 10.1016/j.parkreldis.2014.01.002

DO - 10.1016/j.parkreldis.2014.01.002

M3 - Article

C2 - 24467818

AN - SCOPUS:84897960405

VL - 20

SP - 415

EP - 420

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

SN - 1353-8020

IS - 4

ER -