Abstract
We report here an autopsy case of sporadic Creutzfeldt-Jakob disease (CJD) without hereditary burden and with a clinical course typical of sporadic CJD. A 77-year old man developed memory disturbance, followed by gait disturbance and myoclonus. He died of bronchopneumonia 5 months after the disease onset. Post-mortem examination revealed neuronal loss, astrocytosis, and patchy spongiosis in the cerebral cortex and lenticular nuclei. Synaptic-type deposits of prion protein were present in the cerebral cortex. Additionally, Lewy bodies were observed in the cerebral cortex and substantia nigra. Furthermore, senile plaques compatible with definite Alzheimer's disease according to Consortium to Establish a Registry for Alzheimer's disease criteria and neurofibrillary changes of the limbic system consistent with Braak stage IV were found. Based on a review of the published literature, this autopsy case is very rare, and we suppose that the incidence of CJD accompanied by Lewy body disease and Alzheimer's disease is very low.
| Original language | English |
|---|---|
| Pages (from-to) | 454-459 |
| Number of pages | 6 |
| Journal | Neuropathology |
| Volume | 29 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2009 |
| Externally published | Yes |
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Keywords
- Alzheimer's disease
- Creutzfeldt-Jakob disease
- Lewy body disease
- Neurofibrillary change
- Senile plaque
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Clinical Neurology
Cite this
Coexistence of Creutzfeldt-Jakob disease, Lewy body disease, and Alzheimer's disease pathology : An autopsy case showing typical clinical features of Creutzfeldt-Jakob disease: Case Report. / Haraguchi, Takashi; Terada, Seishi; Ishizu, Hideki; Sakai, Kenichi; Tanabe, Yasuyuki; Nagai, Taiji; Takata, Hiroshi; Nobukuni, Keigo; Ihara, Yuetsu; Kitamoto, Tetsuyuki; Kuroda, Shigetoshi.
In: Neuropathology, Vol. 29, No. 4, 08.2009, p. 454-459.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Coexistence of Creutzfeldt-Jakob disease, Lewy body disease, and Alzheimer's disease pathology
T2 - An autopsy case showing typical clinical features of Creutzfeldt-Jakob disease: Case Report
AU - Haraguchi, Takashi
AU - Terada, Seishi
AU - Ishizu, Hideki
AU - Sakai, Kenichi
AU - Tanabe, Yasuyuki
AU - Nagai, Taiji
AU - Takata, Hiroshi
AU - Nobukuni, Keigo
AU - Ihara, Yuetsu
AU - Kitamoto, Tetsuyuki
AU - Kuroda, Shigetoshi
PY - 2009/8
Y1 - 2009/8
N2 - We report here an autopsy case of sporadic Creutzfeldt-Jakob disease (CJD) without hereditary burden and with a clinical course typical of sporadic CJD. A 77-year old man developed memory disturbance, followed by gait disturbance and myoclonus. He died of bronchopneumonia 5 months after the disease onset. Post-mortem examination revealed neuronal loss, astrocytosis, and patchy spongiosis in the cerebral cortex and lenticular nuclei. Synaptic-type deposits of prion protein were present in the cerebral cortex. Additionally, Lewy bodies were observed in the cerebral cortex and substantia nigra. Furthermore, senile plaques compatible with definite Alzheimer's disease according to Consortium to Establish a Registry for Alzheimer's disease criteria and neurofibrillary changes of the limbic system consistent with Braak stage IV were found. Based on a review of the published literature, this autopsy case is very rare, and we suppose that the incidence of CJD accompanied by Lewy body disease and Alzheimer's disease is very low.
AB - We report here an autopsy case of sporadic Creutzfeldt-Jakob disease (CJD) without hereditary burden and with a clinical course typical of sporadic CJD. A 77-year old man developed memory disturbance, followed by gait disturbance and myoclonus. He died of bronchopneumonia 5 months after the disease onset. Post-mortem examination revealed neuronal loss, astrocytosis, and patchy spongiosis in the cerebral cortex and lenticular nuclei. Synaptic-type deposits of prion protein were present in the cerebral cortex. Additionally, Lewy bodies were observed in the cerebral cortex and substantia nigra. Furthermore, senile plaques compatible with definite Alzheimer's disease according to Consortium to Establish a Registry for Alzheimer's disease criteria and neurofibrillary changes of the limbic system consistent with Braak stage IV were found. Based on a review of the published literature, this autopsy case is very rare, and we suppose that the incidence of CJD accompanied by Lewy body disease and Alzheimer's disease is very low.
KW - Alzheimer's disease
KW - Creutzfeldt-Jakob disease
KW - Lewy body disease
KW - Neurofibrillary change
KW - Senile plaque
UR - http://www.scopus.com/inward/record.url?scp=67651246853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67651246853&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1789.2008.00964.x
DO - 10.1111/j.1440-1789.2008.00964.x
M3 - Article
VL - 29
SP - 454
EP - 459
JO - Neuropathology
JF - Neuropathology
SN - 0919-6544
IS - 4
ER -