Coexistence of Creutzfeldt-Jakob disease, Lewy body disease, and Alzheimer's disease pathology

An autopsy case showing typical clinical features of Creutzfeldt-Jakob disease: Case Report

Takashi Haraguchi, Seishi Terada, Hideki Ishizu, Kenichi Sakai, Yasuyuki Tanabe, Taiji Nagai, Hiroshi Takata, Keigo Nobukuni, Yuetsu Ihara, Tetsuyuki Kitamoto, Shigetoshi Kuroda

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We report here an autopsy case of sporadic Creutzfeldt-Jakob disease (CJD) without hereditary burden and with a clinical course typical of sporadic CJD. A 77-year old man developed memory disturbance, followed by gait disturbance and myoclonus. He died of bronchopneumonia 5 months after the disease onset. Post-mortem examination revealed neuronal loss, astrocytosis, and patchy spongiosis in the cerebral cortex and lenticular nuclei. Synaptic-type deposits of prion protein were present in the cerebral cortex. Additionally, Lewy bodies were observed in the cerebral cortex and substantia nigra. Furthermore, senile plaques compatible with definite Alzheimer's disease according to Consortium to Establish a Registry for Alzheimer's disease criteria and neurofibrillary changes of the limbic system consistent with Braak stage IV were found. Based on a review of the published literature, this autopsy case is very rare, and we suppose that the incidence of CJD accompanied by Lewy body disease and Alzheimer's disease is very low.

Original languageEnglish
Pages (from-to)454-459
Number of pages6
JournalNeuropathology
Volume29
Issue number4
DOIs
Publication statusPublished - Aug 2009
Externally publishedYes

Fingerprint

Lewy Body Disease
Creutzfeldt-Jakob Syndrome
Cerebral Cortex
Autopsy
Alzheimer Disease
Pathology
Lewy Bodies
Corpus Striatum
Bronchopneumonia
Limbic System
Myoclonus
Gliosis
Amyloid Plaques
Substantia Nigra
Gait
Registries
Incidence
Sporadic Creutzfeldt-Jakob Disease

Keywords

  • Alzheimer's disease
  • Creutzfeldt-Jakob disease
  • Lewy body disease
  • Neurofibrillary change
  • Senile plaque

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Coexistence of Creutzfeldt-Jakob disease, Lewy body disease, and Alzheimer's disease pathology : An autopsy case showing typical clinical features of Creutzfeldt-Jakob disease: Case Report. / Haraguchi, Takashi; Terada, Seishi; Ishizu, Hideki; Sakai, Kenichi; Tanabe, Yasuyuki; Nagai, Taiji; Takata, Hiroshi; Nobukuni, Keigo; Ihara, Yuetsu; Kitamoto, Tetsuyuki; Kuroda, Shigetoshi.

In: Neuropathology, Vol. 29, No. 4, 08.2009, p. 454-459.

Research output: Contribution to journalArticle

Haraguchi, Takashi ; Terada, Seishi ; Ishizu, Hideki ; Sakai, Kenichi ; Tanabe, Yasuyuki ; Nagai, Taiji ; Takata, Hiroshi ; Nobukuni, Keigo ; Ihara, Yuetsu ; Kitamoto, Tetsuyuki ; Kuroda, Shigetoshi. / Coexistence of Creutzfeldt-Jakob disease, Lewy body disease, and Alzheimer's disease pathology : An autopsy case showing typical clinical features of Creutzfeldt-Jakob disease: Case Report. In: Neuropathology. 2009 ; Vol. 29, No. 4. pp. 454-459.
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