CO2-expanded liquids as solvents to enhance activity of Pseudozyma antarctica lipase B towards ortho-substituted 1-phenylethanols

Moeko Otsu, Yuichi Suzuki, Afifa Ayu Koesoema, Hai Nam Hoang, Mayumi Tamura, Tomoko Matsuda

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Pseudozyma (Candida) antarctica lipase B (CAL-B, Novozym 435®) is one of the most widely used and outstanding biocatalysts. However, CAL-B-catalyzed transesterification of ortho-substituted 1-phenylethanol analogs suffers low conversion. In this research, the reactions were accelerated by using CO2-expanded liquids, liquids expanded by dissolving pressurized CO2, such as CO2-expanded hexane or CO2-expanded MeTHF.
Original languageEnglish
JournalTetrahedron Letters
Volume61
Issue number42
DOIs
Publication statusPublished - 2020

Keywords

  • CO-expanded liquid
  • Lipase
  • -substituted 1-phenylethanol
  • Bio-based liquid

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