CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia

H. Ujike, M. Takaki, K. Nakata, Y. Tanaka, T. Takeda, M. Kodama, Y. Fujiwara, A. Sakai, S. Kuroda

Research output: Contribution to journalArticlepeer-review

187 Citations (Scopus)

Abstract

To examine the cannabinoid hypothesis for pathogenesis of schizophrenia, we examined two kinds of polymorphisms of the CNR1 gene, which encodes human CB1 receptor, a subclass of central cannabinoid receptors, in schizophrenics and age-matched controls in the Japanese population. Allelic and genotypic distributions of polymorphism 1359G/A at codon 453 in the coding region and AAT triplet repeats in the 3′ flanking region in the Japanese population were quite different from those in Caucasians. Although the polymorphism 1359G/A was not associated with schizophrenia, the triplet repeat polymorphism of the CNR1 gene was significantly associated with schizophrenia, especially the hebephrenic subtype (P = 0.0028). Hebephrenic schizophrenia showed significantly increased rate of the 9 repeat allele (P = 0.032, OR = 2.30, 95% Cl (1.91-2.69)), and decreased rate of the 17 repeat allele (P = 0.011, OR = 0.208, 95% Cl (0.098-0.439)). The present findings indicated that certain alleles or genotypes of the CNR1 gene may confer a susceptibility of schizophrenia, especially of the hebephrenic type.

Original languageEnglish
Pages (from-to)515-518
Number of pages4
JournalMolecular Psychiatry
Volume7
Issue number5
DOIs
Publication statusPublished - 2002

Keywords

  • Association study
  • CNR1 gene
  • Cannabinoid receptor
  • Hebephrenic type
  • Japanese
  • Schizophrenia

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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