Abstract
Clustered DNA damage (locally multiply damaged site) is thought to be a critical lesion caused by ionizing radiation, and high LET radiation such as heavy ion particles is believed to produce high yields of such damage. Since heavy ion particles are major components of ionizing radiation in a space environment, it is important to clarify the chemical nature and biological consequences of clustered DNA damage and its relationship to the health effects of exposure to high LET particles in humans. The concept of clustered DNA damage emerged around 1980, but only recently has become the subject of experimental studies. In this article, we review methods used to detect clustered DNA damage, and the current status of our understanding of the chemical nature and repair of clustered DNA damage.
| Original language | English |
|---|---|
| Pages (from-to) | 206-215 |
| Number of pages | 10 |
| Journal | Biological sciences in space = Uchū seibutsu kagaku |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jan 1 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Clustered DNA damage induced by heavy ion particles. / Terato, Hiroaki; Ide, Hiroshi.
In: Biological sciences in space = Uchū seibutsu kagaku, Vol. 18, No. 4, 01.01.2004, p. 206-215.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Clustered DNA damage induced by heavy ion particles.
AU - Terato, Hiroaki
AU - Ide, Hiroshi
PY - 2004/1/1
Y1 - 2004/1/1
N2 - Clustered DNA damage (locally multiply damaged site) is thought to be a critical lesion caused by ionizing radiation, and high LET radiation such as heavy ion particles is believed to produce high yields of such damage. Since heavy ion particles are major components of ionizing radiation in a space environment, it is important to clarify the chemical nature and biological consequences of clustered DNA damage and its relationship to the health effects of exposure to high LET particles in humans. The concept of clustered DNA damage emerged around 1980, but only recently has become the subject of experimental studies. In this article, we review methods used to detect clustered DNA damage, and the current status of our understanding of the chemical nature and repair of clustered DNA damage.
AB - Clustered DNA damage (locally multiply damaged site) is thought to be a critical lesion caused by ionizing radiation, and high LET radiation such as heavy ion particles is believed to produce high yields of such damage. Since heavy ion particles are major components of ionizing radiation in a space environment, it is important to clarify the chemical nature and biological consequences of clustered DNA damage and its relationship to the health effects of exposure to high LET particles in humans. The concept of clustered DNA damage emerged around 1980, but only recently has become the subject of experimental studies. In this article, we review methods used to detect clustered DNA damage, and the current status of our understanding of the chemical nature and repair of clustered DNA damage.
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UR - http://www.scopus.com/inward/citedby.url?scp=20044368321&partnerID=8YFLogxK
U2 - 10.2187/bss.18.206
DO - 10.2187/bss.18.206
M3 - Review article
C2 - 15858387
AN - SCOPUS:20044368321
VL - 18
SP - 206
EP - 215
JO - Biological sciences in space = Uchū seibutsu kagaku
JF - Biological sciences in space = Uchū seibutsu kagaku
SN - 0914-9201
IS - 4
ER -