Cloning and expression of the chick p63 gene

Akihiro Yasue, Hirotaka Tao, Tsutomu Nohno, Keiji Moriyama, Sumihare Noji, Hideyo Ohuchi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We have isolated a chick cDNA for p63, a member of the p53 transcription factor family. This cDNA encodes a protein of 582 amino acids for an α isoform in the C-terminal region, while lacking the N-terminal transactivation domain. The chick p63 gene is first expressed in the prospective cutaneous ectoderm at stage 6 and later in the developing epithelia. The p63 expression is intense in specialized epithelial structures, such as apical ectodermal ridge of the limb bud, epithelia of branchial arches and feather buds. Furthermore, we have found that the transcripts are detected in the interdigital epithelium, intersomite epithelium, and epaxial dermamyotome. (C) 2001 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalMechanisms of Development
Volume100
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • AER
  • Apical ectodermal ridge
  • Branchial arch
  • Chick
  • Epithelium
  • Feather bud
  • Interdigital epithelium
  • Somite
  • p63

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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