Cloning and characterization of human TNFα promoter region

Shogo Takashiba, Lior Shapira, Salomon Amar, Thomas E. Van Dyke

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

We report the sequence of a 1.2-kb human tumor necrosis factor alpha (TNFα) promoter region, which was cloned using PCR. The sequence has several variations from two previous reports and exhibits many potential DNA-binding sites specific to mammalian gene regulatory proteins inducible by lipopolysaccharides.

Original languageEnglish
Pages (from-to)307-308
Number of pages2
JournalGene
Volume131
Issue number2
DOIs
Publication statusPublished - Sep 15 1993
Externally publishedYes

Keywords

  • Recombinant DNA
  • polymerase chain reaction
  • sequencing
  • transcription factors
  • tumor necrosis factor

ASJC Scopus subject areas

  • Genetics

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