Cloning and characterization of human TNFα promoter region

Shogo Takashiba, Lior Shapira, Salomon Amar, Thomas E. Van Dyke

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

We report the sequence of a 1.2-kb human tumor necrosis factor alpha (TNFα) promoter region, which was cloned using PCR. The sequence has several variations from two previous reports and exhibits many potential DNA-binding sites specific to mammalian gene regulatory proteins inducible by lipopolysaccharides.

Original languageEnglish
Pages (from-to)307-308
Number of pages2
JournalGene
Volume131
Issue number2
DOIs
Publication statusPublished - Sep 15 1993
Externally publishedYes

Fingerprint

Genetic Promoter Regions
Lipopolysaccharides
Organism Cloning
Tumor Necrosis Factor-alpha
Binding Sites
Polymerase Chain Reaction
DNA
Proteins
human TNF protein

Keywords

  • polymerase chain reaction
  • Recombinant DNA
  • sequencing
  • transcription factors
  • tumor necrosis factor

ASJC Scopus subject areas

  • Genetics

Cite this

Cloning and characterization of human TNFα promoter region. / Takashiba, Shogo; Shapira, Lior; Amar, Salomon; Van Dyke, Thomas E.

In: Gene, Vol. 131, No. 2, 15.09.1993, p. 307-308.

Research output: Contribution to journalArticle

Takashiba, Shogo ; Shapira, Lior ; Amar, Salomon ; Van Dyke, Thomas E. / Cloning and characterization of human TNFα promoter region. In: Gene. 1993 ; Vol. 131, No. 2. pp. 307-308.
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