Clonal evolution to acute myeloblastic leukemia with MLL gene rearrangement from trisomy 8 clone

Y. Katayama, H. Takimoto, Nobuharu Fujii, G. Kimura, E. Omoto, M. Harada

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Abstract

A 20-year-old Japanese man was referred because of severe pancytopenia with 14% of abnormal blasts in hypocellular bone marrow. After treatment by granulocyte colony-stimulating factor (G-CSF) and transfusions of red blood cells, spontaneous remission was subsequently achieved. After 3 months' remission, however, the patient developed AML characterized by the abnormal karyotype: 46XY,+8,t(9;11)(p22;q23). FISH study revealed the presence of trisomy 8 clone also in the hypoplastic state. While MLL-AF9 chimeric mRNA was observed in leukemic cells, it was not detectable in bone marrow cells from the hypoplastic state by RT-PCR. This is the first report of a trisomy 8 clone which evolved into one with a MLL gene rearrangement.

Original languageEnglish
Pages (from-to)1380-1382
Number of pages3
JournalLeukemia
Volume11
Issue number8
Publication statusPublished - 1997

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Keywords

  • Clonal evolution
  • MLL gene rearrangement
  • Trisomy 8

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

Cite this

Katayama, Y., Takimoto, H., Fujii, N., Kimura, G., Omoto, E., & Harada, M. (1997). Clonal evolution to acute myeloblastic leukemia with MLL gene rearrangement from trisomy 8 clone. Leukemia, 11(8), 1380-1382.