Clinicopathological study of patients with immune complex type and pauci immune type rapidly progressive glomerulonephritis

Hitoshi Sugiyama, Hirofumi Makino, J. Wada, Kosuke Ota, Yoshio Nagake, Shigeru Morioka, Yasushi Yamasaki, Kenichi Shikata, Naoki Kashihara, Syuji Ikeda, Toshio Ogura, Zensuke Ota

Research output: Contribution to journalArticlepeer-review

Abstract

We made clinicopathological studies of twelve patients with rapidly progressive glomerulonephritis (RPGN) treated at our department of Okayama University Medical School Hospital for the last eight years. By immunofluorescence microscopy, seven cases were immune complex (IC) type and five were pauci immune type. By light microscopy, the mean percentage of glomeruli with crescents was seventy five, and cellular and fibro-cellular crescents were dominant in eleven cases. Combined therapy including methylprednisolone pulse or oral steroid was effective in eleven. Hemodialysis was performed in four patients with severe uremia and three of them recovered from hemodialysis. Two cases of RPGN associated with systemic lupus erythematosus died of cerebral hemorrhage. We conclude that IC type and pauci immune type RPGN have good prognosis when treated at their active stage with intensive combined therapy and with hemodialysis if necessary.

Original languageEnglish
Pages (from-to)777-782
Number of pages6
JournalJapanese Journal of Nephrology
Volume35
Issue number6
DOIs
Publication statusPublished - Jan 1 1993

Keywords

  • combined therapy
  • crescent
  • immune complex (IC) type
  • pauci immune type
  • rapidly progressive glomerulonephritis (RPGN)

ASJC Scopus subject areas

  • Nephrology

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