Abstract
The gastrointestinal (GI) tract is the most common primary site of extranodal diffuse large B-cell lymphoma (DLBCL), with approximately one-third of extranodal DLBCL occurring in the GI tract. We investigated the clinicopathological features and immunohistochemically-assessed cell-of-origin of 49 GI DLBCL cases (stomach, 24; small intestine, 10; colon, 15) and also examined the presence of MYD88 L265P as recently this mutation has been frequently identified in ABC-like DLBCL, particularly in extranodal sites. Small intestinal DLBCL was characterized by the preponderance of women (P = 0.041) and elevated LDH (P = 0.002) and soluble interleukin-2 receptor (P = 0.033). Small intestinal DLBCL more frequently showed anemia (P = 0.031) and elevated CRP (P = 0.029) than gastric DLBCL. ABC-like phenotype was seen in 71.4 % cases (stomach, 79 %; small intestine, 70 %; colon, 60 %). MYD88 L265P was detected in 6.1 % cases; all were primary gastric DLBCL with ABC-like phenotype but had no distinct clinicopathological features. In conclusion, GI DLBCL had different clinicopathological features according to the primary site especially in the small intestine. Also, MYD88 L265P had little involvement in GI DLBCL compared with other extranodal DLBCLs, suggesting that its pathogenesis might be different from that of organs with a high frequency of MYD88 L265P.
| Original language | English |
|---|---|
| Pages (from-to) | 444-452 |
| Number of pages | 9 |
| Journal | Pathology International |
| Volume | 66 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1 2016 |
Fingerprint
Keywords
- diffuse large B-cell lymphoma
- gastrointestinal tract
- MYD88 L265P
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Clinicopathological features of 49 primary gastrointestinal diffuse large B-cell lymphoma cases; comparison with location, cell-of-origin, and frequency of MYD88 L265P. / Nagakita, Keina; Takata, Katsuyoshi; Taniguchi, Kouhei; Miyata-Takata, Tomoko; Sato, Yasuharu; Tari, Akira; Ohnishi, Nobuhiko; Noujima-Harada, Mai; Omote, Shizuma; Nakamura, Naoya; Iwamuro, Masaya; Maeda, Yoshinobu; Okada, Hiroyuki; Tanimoto, Mitsune; Yoshino, Tadashi.
In: Pathology International, Vol. 66, No. 8, 01.08.2016, p. 444-452.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinicopathological features of 49 primary gastrointestinal diffuse large B-cell lymphoma cases; comparison with location, cell-of-origin, and frequency of MYD88 L265P
AU - Nagakita, Keina
AU - Takata, Katsuyoshi
AU - Taniguchi, Kouhei
AU - Miyata-Takata, Tomoko
AU - Sato, Yasuharu
AU - Tari, Akira
AU - Ohnishi, Nobuhiko
AU - Noujima-Harada, Mai
AU - Omote, Shizuma
AU - Nakamura, Naoya
AU - Iwamuro, Masaya
AU - Maeda, Yoshinobu
AU - Okada, Hiroyuki
AU - Tanimoto, Mitsune
AU - Yoshino, Tadashi
PY - 2016/8/1
Y1 - 2016/8/1
N2 - The gastrointestinal (GI) tract is the most common primary site of extranodal diffuse large B-cell lymphoma (DLBCL), with approximately one-third of extranodal DLBCL occurring in the GI tract. We investigated the clinicopathological features and immunohistochemically-assessed cell-of-origin of 49 GI DLBCL cases (stomach, 24; small intestine, 10; colon, 15) and also examined the presence of MYD88 L265P as recently this mutation has been frequently identified in ABC-like DLBCL, particularly in extranodal sites. Small intestinal DLBCL was characterized by the preponderance of women (P = 0.041) and elevated LDH (P = 0.002) and soluble interleukin-2 receptor (P = 0.033). Small intestinal DLBCL more frequently showed anemia (P = 0.031) and elevated CRP (P = 0.029) than gastric DLBCL. ABC-like phenotype was seen in 71.4 % cases (stomach, 79 %; small intestine, 70 %; colon, 60 %). MYD88 L265P was detected in 6.1 % cases; all were primary gastric DLBCL with ABC-like phenotype but had no distinct clinicopathological features. In conclusion, GI DLBCL had different clinicopathological features according to the primary site especially in the small intestine. Also, MYD88 L265P had little involvement in GI DLBCL compared with other extranodal DLBCLs, suggesting that its pathogenesis might be different from that of organs with a high frequency of MYD88 L265P.
AB - The gastrointestinal (GI) tract is the most common primary site of extranodal diffuse large B-cell lymphoma (DLBCL), with approximately one-third of extranodal DLBCL occurring in the GI tract. We investigated the clinicopathological features and immunohistochemically-assessed cell-of-origin of 49 GI DLBCL cases (stomach, 24; small intestine, 10; colon, 15) and also examined the presence of MYD88 L265P as recently this mutation has been frequently identified in ABC-like DLBCL, particularly in extranodal sites. Small intestinal DLBCL was characterized by the preponderance of women (P = 0.041) and elevated LDH (P = 0.002) and soluble interleukin-2 receptor (P = 0.033). Small intestinal DLBCL more frequently showed anemia (P = 0.031) and elevated CRP (P = 0.029) than gastric DLBCL. ABC-like phenotype was seen in 71.4 % cases (stomach, 79 %; small intestine, 70 %; colon, 60 %). MYD88 L265P was detected in 6.1 % cases; all were primary gastric DLBCL with ABC-like phenotype but had no distinct clinicopathological features. In conclusion, GI DLBCL had different clinicopathological features according to the primary site especially in the small intestine. Also, MYD88 L265P had little involvement in GI DLBCL compared with other extranodal DLBCLs, suggesting that its pathogenesis might be different from that of organs with a high frequency of MYD88 L265P.
KW - diffuse large B-cell lymphoma
KW - gastrointestinal tract
KW - MYD88 L265P
UR - http://www.scopus.com/inward/record.url?scp=84979620807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84979620807&partnerID=8YFLogxK
U2 - 10.1111/pin.12439
DO - 10.1111/pin.12439
M3 - Article
C2 - 27439595
AN - SCOPUS:84979620807
VL - 66
SP - 444
EP - 452
JO - Pathology International
JF - Pathology International
SN - 1320-5463
IS - 8
ER -