Clinicopathological features and outcomes of endoscopic submucosal dissection for superficial cancer of the pharynx

Research output: Contribution to journalArticle

Abstract

The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. "Resect and watch" is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalActa medica Okayama
Volume73
Issue number2
Publication statusPublished - Jan 1 2019

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Pharyngeal Neoplasms
Dissection
Head and Neck Neoplasms
Survival Rate
Pyriform Sinus
Safety
Watches
Esophageal Neoplasms
Lymph Node Excision
Tumors
Neoplasms
Therapeutics
Lymph Nodes
Endoscopic Mucosal Resection
Neoplasm Metastasis
Recurrence

Keywords

  • Endoscopic resection
  • Endoscopic submucosal dissection
  • Pharynx
  • Superficial cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Clinicopathological features and outcomes of endoscopic submucosal dissection for superficial cancer of the pharynx",
abstract = "The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0{\%} and 50.8{\%} had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7{\%} of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9{\%}. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3{\%}) and inconclusive in 27 lesions (38.6{\%}), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5{\%} (95{\%}CI: 76.6-97.3{\%}) and the cause-specific survival rate was 97.6{\%} (95{\%}CI: 84.9-99.7{\%}). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. {"}Resect and watch{"} is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer.",
keywords = "Endoscopic resection, Endoscopic submucosal dissection, Pharynx, Superficial cancer",
author = "Makoto Abe and Masaya Iwamuro and Yoshiro Kawahara and Hiromitsu Kanzaki and Seiji Kawano and Takehiro Tanaka and Munechika Tsumura and Takuma Makino and Yohei Noda and Hidenori Marunaka and Kazunori Nishizaki and Hiroyuki Okada",
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AU - Abe, Makoto

AU - Iwamuro, Masaya

AU - Kawahara, Yoshiro

AU - Kanzaki, Hiromitsu

AU - Kawano, Seiji

AU - Tanaka, Takehiro

AU - Tsumura, Munechika

AU - Makino, Takuma

AU - Noda, Yohei

AU - Marunaka, Hidenori

AU - Nishizaki, Kazunori

AU - Okada, Hiroyuki

PY - 2019/1/1

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N2 - The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. "Resect and watch" is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer.

AB - The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. "Resect and watch" is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer.

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