Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer

Hiroko Yamashita, Akiko Ogiya, Tadahiko Shien, Yoshiya Horimoto, Norikazu Masuda, Touko Inao, Tomofumi Osako, Masato Takahashi, Yumi Endo, Mitsuchika Hosoda, Naoko Ishida, Rie Horii, Kieko Yamazaki, Yuichiro Miyoshi, Hiroyuki Yasojima, Nobumoto Tomioka, Study Group Of Scientific Research Of The Japanese Breast Cancer Society Collaborative Study Group Of Scientific Research Of The Japanese Breast Cancer Society

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Most studies analyzing prognostic factors for late relapse have been performed in postmenopausal women who received tamoxifen or aromatase inhibitors as adjuvant endocrine therapy for estrogen receptor (ER)-positive breast cancer. Methods: A total of 223 patients (108 premenopausal and 115 postmenopausal) with early distant recurrence and 149 patients (62 premenopausal and 87 postmenopausal) with late distant recurrence of ER-positive, HER2-negative breast cancer who were given their initial treatment between 2000 and 2004 were registered from nine institutions. For each late recurrence patient, approximately two matched control patients without relapse for more than 10 years were selected. Clinicopathological factors and adjuvant therapies were compared among the three groups by menopausal status and age. Results: Factors predicting early recurrence in premenopausal women were large tumor size, high lymph node category and high tumor grade, whereas predictors for late recurrence were large tumor size and high lymph node category. In postmenopausal women under 60 years of age, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, low PgR expression and high Ki67 labeling index (LI), while predictors for late recurrence were large tumor size and high lymph node category. On the other hand, in postmenopausal women aged 60 years or older, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, high tumor grade, low ER expression and high Ki67 LI, whereas predictors for late recurrence were high lymph node category, low ER expression and short duration of adjuvant endocrine therapy. Conclusion: Predictors of early and late distant recurrence might differ according to menopausal status and age.

Original languageEnglish
JournalBreast Cancer
DOIs
Publication statusAccepted/In press - Oct 14 2015

Fingerprint

Estrogen Receptors
Breast Neoplasms
Recurrence
Lymph Nodes
Neoplasms
Aromatase Inhibitors
Age Factors
Tamoxifen
Therapeutics

Keywords

  • Breast cancer
  • Early recurrence
  • Estrogen receptor positive
  • HER2 negative
  • Late recurrence

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

Cite this

Yamashita, H., Ogiya, A., Shien, T., Horimoto, Y., Masuda, N., Inao, T., ... Collaborative Study Group Of Scientific Research Of The Japanese Breast Cancer Society, S. G. O. S. R. O. T. J. B. C. S. (Accepted/In press). Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer. Breast Cancer. https://doi.org/10.1007/s12282-015-0649-0

Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer. / Yamashita, Hiroko; Ogiya, Akiko; Shien, Tadahiko; Horimoto, Yoshiya; Masuda, Norikazu; Inao, Touko; Osako, Tomofumi; Takahashi, Masato; Endo, Yumi; Hosoda, Mitsuchika; Ishida, Naoko; Horii, Rie; Yamazaki, Kieko; Miyoshi, Yuichiro; Yasojima, Hiroyuki; Tomioka, Nobumoto; Collaborative Study Group Of Scientific Research Of The Japanese Breast Cancer Society, Study Group Of Scientific Research Of The Japanese Breast Cancer Society.

In: Breast Cancer, 14.10.2015.

Research output: Contribution to journalArticle

Yamashita, H, Ogiya, A, Shien, T, Horimoto, Y, Masuda, N, Inao, T, Osako, T, Takahashi, M, Endo, Y, Hosoda, M, Ishida, N, Horii, R, Yamazaki, K, Miyoshi, Y, Yasojima, H, Tomioka, N & Collaborative Study Group Of Scientific Research Of The Japanese Breast Cancer Society, SGOSROTJBCS 2015, 'Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer', Breast Cancer. https://doi.org/10.1007/s12282-015-0649-0
Yamashita, Hiroko ; Ogiya, Akiko ; Shien, Tadahiko ; Horimoto, Yoshiya ; Masuda, Norikazu ; Inao, Touko ; Osako, Tomofumi ; Takahashi, Masato ; Endo, Yumi ; Hosoda, Mitsuchika ; Ishida, Naoko ; Horii, Rie ; Yamazaki, Kieko ; Miyoshi, Yuichiro ; Yasojima, Hiroyuki ; Tomioka, Nobumoto ; Collaborative Study Group Of Scientific Research Of The Japanese Breast Cancer Society, Study Group Of Scientific Research Of The Japanese Breast Cancer Society. / Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer. In: Breast Cancer. 2015.
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abstract = "Background: Most studies analyzing prognostic factors for late relapse have been performed in postmenopausal women who received tamoxifen or aromatase inhibitors as adjuvant endocrine therapy for estrogen receptor (ER)-positive breast cancer. Methods: A total of 223 patients (108 premenopausal and 115 postmenopausal) with early distant recurrence and 149 patients (62 premenopausal and 87 postmenopausal) with late distant recurrence of ER-positive, HER2-negative breast cancer who were given their initial treatment between 2000 and 2004 were registered from nine institutions. For each late recurrence patient, approximately two matched control patients without relapse for more than 10 years were selected. Clinicopathological factors and adjuvant therapies were compared among the three groups by menopausal status and age. Results: Factors predicting early recurrence in premenopausal women were large tumor size, high lymph node category and high tumor grade, whereas predictors for late recurrence were large tumor size and high lymph node category. In postmenopausal women under 60 years of age, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, low PgR expression and high Ki67 labeling index (LI), while predictors for late recurrence were large tumor size and high lymph node category. On the other hand, in postmenopausal women aged 60 years or older, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, high tumor grade, low ER expression and high Ki67 LI, whereas predictors for late recurrence were high lymph node category, low ER expression and short duration of adjuvant endocrine therapy. Conclusion: Predictors of early and late distant recurrence might differ according to menopausal status and age.",
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T1 - Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer

AU - Yamashita, Hiroko

AU - Ogiya, Akiko

AU - Shien, Tadahiko

AU - Horimoto, Yoshiya

AU - Masuda, Norikazu

AU - Inao, Touko

AU - Osako, Tomofumi

AU - Takahashi, Masato

AU - Endo, Yumi

AU - Hosoda, Mitsuchika

AU - Ishida, Naoko

AU - Horii, Rie

AU - Yamazaki, Kieko

AU - Miyoshi, Yuichiro

AU - Yasojima, Hiroyuki

AU - Tomioka, Nobumoto

AU - Collaborative Study Group Of Scientific Research Of The Japanese Breast Cancer Society, Study Group Of Scientific Research Of The Japanese Breast Cancer Society

PY - 2015/10/14

Y1 - 2015/10/14

N2 - Background: Most studies analyzing prognostic factors for late relapse have been performed in postmenopausal women who received tamoxifen or aromatase inhibitors as adjuvant endocrine therapy for estrogen receptor (ER)-positive breast cancer. Methods: A total of 223 patients (108 premenopausal and 115 postmenopausal) with early distant recurrence and 149 patients (62 premenopausal and 87 postmenopausal) with late distant recurrence of ER-positive, HER2-negative breast cancer who were given their initial treatment between 2000 and 2004 were registered from nine institutions. For each late recurrence patient, approximately two matched control patients without relapse for more than 10 years were selected. Clinicopathological factors and adjuvant therapies were compared among the three groups by menopausal status and age. Results: Factors predicting early recurrence in premenopausal women were large tumor size, high lymph node category and high tumor grade, whereas predictors for late recurrence were large tumor size and high lymph node category. In postmenopausal women under 60 years of age, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, low PgR expression and high Ki67 labeling index (LI), while predictors for late recurrence were large tumor size and high lymph node category. On the other hand, in postmenopausal women aged 60 years or older, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, high tumor grade, low ER expression and high Ki67 LI, whereas predictors for late recurrence were high lymph node category, low ER expression and short duration of adjuvant endocrine therapy. Conclusion: Predictors of early and late distant recurrence might differ according to menopausal status and age.

AB - Background: Most studies analyzing prognostic factors for late relapse have been performed in postmenopausal women who received tamoxifen or aromatase inhibitors as adjuvant endocrine therapy for estrogen receptor (ER)-positive breast cancer. Methods: A total of 223 patients (108 premenopausal and 115 postmenopausal) with early distant recurrence and 149 patients (62 premenopausal and 87 postmenopausal) with late distant recurrence of ER-positive, HER2-negative breast cancer who were given their initial treatment between 2000 and 2004 were registered from nine institutions. For each late recurrence patient, approximately two matched control patients without relapse for more than 10 years were selected. Clinicopathological factors and adjuvant therapies were compared among the three groups by menopausal status and age. Results: Factors predicting early recurrence in premenopausal women were large tumor size, high lymph node category and high tumor grade, whereas predictors for late recurrence were large tumor size and high lymph node category. In postmenopausal women under 60 years of age, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, low PgR expression and high Ki67 labeling index (LI), while predictors for late recurrence were large tumor size and high lymph node category. On the other hand, in postmenopausal women aged 60 years or older, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, high tumor grade, low ER expression and high Ki67 LI, whereas predictors for late recurrence were high lymph node category, low ER expression and short duration of adjuvant endocrine therapy. Conclusion: Predictors of early and late distant recurrence might differ according to menopausal status and age.

KW - Breast cancer

KW - Early recurrence

KW - Estrogen receptor positive

KW - HER2 negative

KW - Late recurrence

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