TY - JOUR
T1 - Clinicopathological differential diagnosis of IgG4-related disease
T2 - A historical overview and a proposal of the criteria for excluding mimickers of IgG4-related disease
AU - Satou, Akira
AU - Notohara, Kenji
AU - Zen, Yoh
AU - Nakamura, Shigeo
AU - Yoshino, Tadashi
AU - Okazaki, Kazuichi
AU - Sato, Yasuharu
N1 - Funding Information:
This work was supported by Intractable Diseases for IgG4‐related Disease, the Health and Labor Sciences Research Grants from Ministry of Health, Labor and Welfare, Japan. Dr. Masaru Kojima (1956–2018) was the pioneer of lympho‐inflammatory disease pathology and contributed significantly to work in this field. We dedicate this paper to Dr. Kojima.
Publisher Copyright:
© 2020 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd
PY - 2020/7/1
Y1 - 2020/7/1
N2 - IgG4-related disease (RD) is a relatively new entity, which was first proposed in 2001. Since then, clinical and pathological characteristics of the disease have been investigated. As IgG4-RD has been studied extensively, the diagnostic criteria for IgG4-RD of each organ and the comprehensive diagnostic criteria for IgG4-RD have also been developed. However, one of the biggest challenges in the field is distinguishing between IgG4-RD and mimickers, which show overlapping features with IgG4-RD. It is now known that some non-IgG4-RDs may meet the diagnostic criteria of IgG4-RD and can be misdiagnosed as IgG4-RD. However, accurate diagnosis is crucial, as the treatments for IgG4-RD and those for other diseases that may be misdiagnosed as IgG4-RD are different. This prompted us to create and propose comprehensive exclusion criteria for IgG4-RD. In this review, we have described the comprehensive exclusion criteria for IgG4-RD, with a historical overview of the disease. These exclusion criteria were recently created by the Research Program for Intractable Disease of the Ministry of Health, Labor, and Welfare of Japan, All Japan IgG4 team, to support correct and accurate diagnosis of IgG4-RD.
AB - IgG4-related disease (RD) is a relatively new entity, which was first proposed in 2001. Since then, clinical and pathological characteristics of the disease have been investigated. As IgG4-RD has been studied extensively, the diagnostic criteria for IgG4-RD of each organ and the comprehensive diagnostic criteria for IgG4-RD have also been developed. However, one of the biggest challenges in the field is distinguishing between IgG4-RD and mimickers, which show overlapping features with IgG4-RD. It is now known that some non-IgG4-RDs may meet the diagnostic criteria of IgG4-RD and can be misdiagnosed as IgG4-RD. However, accurate diagnosis is crucial, as the treatments for IgG4-RD and those for other diseases that may be misdiagnosed as IgG4-RD are different. This prompted us to create and propose comprehensive exclusion criteria for IgG4-RD. In this review, we have described the comprehensive exclusion criteria for IgG4-RD, with a historical overview of the disease. These exclusion criteria were recently created by the Research Program for Intractable Disease of the Ministry of Health, Labor, and Welfare of Japan, All Japan IgG4 team, to support correct and accurate diagnosis of IgG4-RD.
KW - IgG4-related disease
KW - criteria
KW - diagnosis
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U2 - 10.1111/pin.12932
DO - 10.1111/pin.12932
M3 - Review article
C2 - 32314497
AN - SCOPUS:85083676131
VL - 70
SP - 391
EP - 402
JO - Acta Pathologica Japonica
JF - Acta Pathologica Japonica
SN - 1320-5463
IS - 7
ER -