Clinicopathological characterization of Pick's disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions.

Osamu Yokota, Kuniaki Tsuchiya, Tetsuaki Arai, Saburo Yagishita, Osamu Matsubara, Akihide Mochizuki, Akira Tamaoka, Mitsuru Kawamura, Hidetoshi Yoshida, Seishi Terada, Hideki Ishizu, Shigetoshi Kuroda, Haruhiko Akiyama

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Abstract

Although frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions (FTLD-TDP) and Pick's disease are common pathological substrates in sporadic FTLD, clinical differentiation of these diseases is difficult. We performed a retrospective review of medical records and semiquantitative examination of neuronal loss of 20 sporadic FTLD-TDP and 19 Pick's disease cases. Semantic dementia as the first syndrome developed only in FTLD-TDP patients. Impaired speech output in the early stage was five times more frequent in Pick's disease than in FTLD-TDP. The total frequency of asymmetric motor disturbances (e.g., parkinsonism, pyramidal signs, and contracture) during the course was significantly more frequent in FTLD-TDP (78%) than in Pick's disease cases (14%). Asymmetric pyramidal signs were found in 7 of 13 FTLD-TDP cases with corticospinal tract degeneration similar to primary lateral sclerosis. Frontotemporal dementia as the first syndrome was noted in both FTLD-TDP (28%) and Pick's disease cases (64%); however, only FTLD-TDP cases subsequently developed asymmetric motor disturbances, and some of the cases further exhibited hemineglect. Concordant with these clinical findings, degeneration in the temporal cortex, caudate nucleus, putamen, globus pallidus, substantia nigra, and corticospinal tract was significantly more severe in FTLD-TDP, and degeneration in the frontal cortex tended to be more severe in Pick's disease. Given these findings, the initial impairment of semantic memory or comprehension and subsequent asymmetric motor disturbances in sporadic FTLD patients predict sporadic FTLD-TDP rather than Pick's disease, while initial behavioral symptoms or non-fluent aphasia without subsequent asymmetric motor disturbances predict Pick's disease rather than sporadic FTLD-TDP.

Original languageEnglish
Pages (from-to)429-444
Number of pages16
JournalActa Neuropathologica
Volume117
Issue number4
DOIs
Publication statusPublished - Apr 2009
Externally publishedYes

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Pick Disease of the Brain
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Ubiquitin
Pyramidal Tracts
Behavioral Symptoms
Motor Neuron Disease
Globus Pallidus
Caudate Nucleus
Aphasia
Putamen
Parkinsonian Disorders
Frontal Lobe
Contracture
Substantia Nigra
Temporal Lobe
Semantics

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Cellular and Molecular Neuroscience

Cite this

Clinicopathological characterization of Pick's disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions. / Yokota, Osamu; Tsuchiya, Kuniaki; Arai, Tetsuaki; Yagishita, Saburo; Matsubara, Osamu; Mochizuki, Akihide; Tamaoka, Akira; Kawamura, Mitsuru; Yoshida, Hidetoshi; Terada, Seishi; Ishizu, Hideki; Kuroda, Shigetoshi; Akiyama, Haruhiko.

In: Acta Neuropathologica, Vol. 117, No. 4, 04.2009, p. 429-444.

Research output: Contribution to journalArticle

Yokota, O, Tsuchiya, K, Arai, T, Yagishita, S, Matsubara, O, Mochizuki, A, Tamaoka, A, Kawamura, M, Yoshida, H, Terada, S, Ishizu, H, Kuroda, S & Akiyama, H 2009, 'Clinicopathological characterization of Pick's disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions.', Acta Neuropathologica, vol. 117, no. 4, pp. 429-444. https://doi.org/10.1007/s00401-009-0493-4
Yokota, Osamu ; Tsuchiya, Kuniaki ; Arai, Tetsuaki ; Yagishita, Saburo ; Matsubara, Osamu ; Mochizuki, Akihide ; Tamaoka, Akira ; Kawamura, Mitsuru ; Yoshida, Hidetoshi ; Terada, Seishi ; Ishizu, Hideki ; Kuroda, Shigetoshi ; Akiyama, Haruhiko. / Clinicopathological characterization of Pick's disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions. In: Acta Neuropathologica. 2009 ; Vol. 117, No. 4. pp. 429-444.
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