Clinicopathologic manifestations of Epstein-Barr virus-associated cutaneous lymphoproliferative disorders

Keiji Iwatsuki, Mikio Ohtsuka, Hiroshi Harada, Gangwen Han, Fumio Kaneko

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Objective: To elucidate clinicopathologic manifestations of cutaneous lymphoproliferative disorders associated with Epstein-Barr virus (EBV) infection. Design: Retrospective survey of case series Setting: University hospital medical center. Patients: Sixty-five patients with cutaneous lymphomas and related disorders. Main Outcome Measures: Detection of EBV genes and EBV-encoded small nuclear RNAs. Results: Evidence of latent EBV infection was demonstrated in 15 patients: 3 had malignant lymphoma with clinical features mimicking cytophagic histiocytic panniculitis, 6 had facial vesiculopapular eruptions mimicking hydroa vacciniforme, 4 had angiocentric lymphoma, 1 had histiocytoid lymphoma associated with hemophagocytosis, and 1 had plasmacytoma. Hypersensitivity to mosquito bites was noted in a patient with hydroa vacciniforme-like eruptions and another with histiocytoid lymphoma. Angiocentric infiltration of atypical lymphoid cells was a common histological feature in the patients with hydroa vacciniforme-like eruptions and angiocentric lymphoma. No evidence of EBV infection was apparent in 19 patients with mycosis fungoides or Sezary syndrome, 7 with adult T-cell leukemia or lymphoma, 3 with lymphomatoid papulosis (type A), and 2 with lymphocytoma cutis. Conclusion: Patients with EBV-associated cutaneous lymphoproliferative disorders present with unique and diagnostic clinicopathologic features distinct from those of mycosis fungoides or Sezary syndrome.

Original languageEnglish
Pages (from-to)1081-1086
Number of pages6
JournalArchives of Dermatology
Volume133
Issue number9
Publication statusPublished - Sep 1997
Externally publishedYes

Fingerprint

Lymphoproliferative Disorders
Human Herpesvirus 4
Hydroa Vacciniforme
Lymphoma
Skin
Epstein-Barr Virus Infections
Sezary Syndrome
Mycosis Fungoides
Lymphomatoid Papulosis
Pseudolymphoma
Panniculitis
Small Nuclear RNA
Adult T Cell Leukemia Lymphoma
Plasmacytoma
Bites and Stings
Culicidae
Hypersensitivity
Outcome Assessment (Health Care)
Lymphocytes
Genes

ASJC Scopus subject areas

  • Dermatology

Cite this

Iwatsuki, K., Ohtsuka, M., Harada, H., Han, G., & Kaneko, F. (1997). Clinicopathologic manifestations of Epstein-Barr virus-associated cutaneous lymphoproliferative disorders. Archives of Dermatology, 133(9), 1081-1086.

Clinicopathologic manifestations of Epstein-Barr virus-associated cutaneous lymphoproliferative disorders. / Iwatsuki, Keiji; Ohtsuka, Mikio; Harada, Hiroshi; Han, Gangwen; Kaneko, Fumio.

In: Archives of Dermatology, Vol. 133, No. 9, 09.1997, p. 1081-1086.

Research output: Contribution to journalArticle

Iwatsuki, K, Ohtsuka, M, Harada, H, Han, G & Kaneko, F 1997, 'Clinicopathologic manifestations of Epstein-Barr virus-associated cutaneous lymphoproliferative disorders', Archives of Dermatology, vol. 133, no. 9, pp. 1081-1086.
Iwatsuki, Keiji ; Ohtsuka, Mikio ; Harada, Hiroshi ; Han, Gangwen ; Kaneko, Fumio. / Clinicopathologic manifestations of Epstein-Barr virus-associated cutaneous lymphoproliferative disorders. In: Archives of Dermatology. 1997 ; Vol. 133, No. 9. pp. 1081-1086.
@article{33bf11a798934f40b6e6d27239b0e0a8,
title = "Clinicopathologic manifestations of Epstein-Barr virus-associated cutaneous lymphoproliferative disorders",
abstract = "Objective: To elucidate clinicopathologic manifestations of cutaneous lymphoproliferative disorders associated with Epstein-Barr virus (EBV) infection. Design: Retrospective survey of case series Setting: University hospital medical center. Patients: Sixty-five patients with cutaneous lymphomas and related disorders. Main Outcome Measures: Detection of EBV genes and EBV-encoded small nuclear RNAs. Results: Evidence of latent EBV infection was demonstrated in 15 patients: 3 had malignant lymphoma with clinical features mimicking cytophagic histiocytic panniculitis, 6 had facial vesiculopapular eruptions mimicking hydroa vacciniforme, 4 had angiocentric lymphoma, 1 had histiocytoid lymphoma associated with hemophagocytosis, and 1 had plasmacytoma. Hypersensitivity to mosquito bites was noted in a patient with hydroa vacciniforme-like eruptions and another with histiocytoid lymphoma. Angiocentric infiltration of atypical lymphoid cells was a common histological feature in the patients with hydroa vacciniforme-like eruptions and angiocentric lymphoma. No evidence of EBV infection was apparent in 19 patients with mycosis fungoides or Sezary syndrome, 7 with adult T-cell leukemia or lymphoma, 3 with lymphomatoid papulosis (type A), and 2 with lymphocytoma cutis. Conclusion: Patients with EBV-associated cutaneous lymphoproliferative disorders present with unique and diagnostic clinicopathologic features distinct from those of mycosis fungoides or Sezary syndrome.",
author = "Keiji Iwatsuki and Mikio Ohtsuka and Hiroshi Harada and Gangwen Han and Fumio Kaneko",
year = "1997",
month = "9",
language = "English",
volume = "133",
pages = "1081--1086",
journal = "JAMA Dermatology",
issn = "2168-6068",
publisher = "American Medical Association",
number = "9",

}

TY - JOUR

T1 - Clinicopathologic manifestations of Epstein-Barr virus-associated cutaneous lymphoproliferative disorders

AU - Iwatsuki, Keiji

AU - Ohtsuka, Mikio

AU - Harada, Hiroshi

AU - Han, Gangwen

AU - Kaneko, Fumio

PY - 1997/9

Y1 - 1997/9

N2 - Objective: To elucidate clinicopathologic manifestations of cutaneous lymphoproliferative disorders associated with Epstein-Barr virus (EBV) infection. Design: Retrospective survey of case series Setting: University hospital medical center. Patients: Sixty-five patients with cutaneous lymphomas and related disorders. Main Outcome Measures: Detection of EBV genes and EBV-encoded small nuclear RNAs. Results: Evidence of latent EBV infection was demonstrated in 15 patients: 3 had malignant lymphoma with clinical features mimicking cytophagic histiocytic panniculitis, 6 had facial vesiculopapular eruptions mimicking hydroa vacciniforme, 4 had angiocentric lymphoma, 1 had histiocytoid lymphoma associated with hemophagocytosis, and 1 had plasmacytoma. Hypersensitivity to mosquito bites was noted in a patient with hydroa vacciniforme-like eruptions and another with histiocytoid lymphoma. Angiocentric infiltration of atypical lymphoid cells was a common histological feature in the patients with hydroa vacciniforme-like eruptions and angiocentric lymphoma. No evidence of EBV infection was apparent in 19 patients with mycosis fungoides or Sezary syndrome, 7 with adult T-cell leukemia or lymphoma, 3 with lymphomatoid papulosis (type A), and 2 with lymphocytoma cutis. Conclusion: Patients with EBV-associated cutaneous lymphoproliferative disorders present with unique and diagnostic clinicopathologic features distinct from those of mycosis fungoides or Sezary syndrome.

AB - Objective: To elucidate clinicopathologic manifestations of cutaneous lymphoproliferative disorders associated with Epstein-Barr virus (EBV) infection. Design: Retrospective survey of case series Setting: University hospital medical center. Patients: Sixty-five patients with cutaneous lymphomas and related disorders. Main Outcome Measures: Detection of EBV genes and EBV-encoded small nuclear RNAs. Results: Evidence of latent EBV infection was demonstrated in 15 patients: 3 had malignant lymphoma with clinical features mimicking cytophagic histiocytic panniculitis, 6 had facial vesiculopapular eruptions mimicking hydroa vacciniforme, 4 had angiocentric lymphoma, 1 had histiocytoid lymphoma associated with hemophagocytosis, and 1 had plasmacytoma. Hypersensitivity to mosquito bites was noted in a patient with hydroa vacciniforme-like eruptions and another with histiocytoid lymphoma. Angiocentric infiltration of atypical lymphoid cells was a common histological feature in the patients with hydroa vacciniforme-like eruptions and angiocentric lymphoma. No evidence of EBV infection was apparent in 19 patients with mycosis fungoides or Sezary syndrome, 7 with adult T-cell leukemia or lymphoma, 3 with lymphomatoid papulosis (type A), and 2 with lymphocytoma cutis. Conclusion: Patients with EBV-associated cutaneous lymphoproliferative disorders present with unique and diagnostic clinicopathologic features distinct from those of mycosis fungoides or Sezary syndrome.

UR - http://www.scopus.com/inward/record.url?scp=0030885830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030885830&partnerID=8YFLogxK

M3 - Article

VL - 133

SP - 1081

EP - 1086

JO - JAMA Dermatology

JF - JAMA Dermatology

SN - 2168-6068

IS - 9

ER -