Clinicopathologic manifestations of Epstein-Barr virus-associated cutaneous lymphoproliferative disorders

Keiji Iwatsuki, Mikio Ohtsuka, Hiroshi Harada, Gangwen Han, Fumio Kaneko

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111 Citations (Scopus)


Objective: To elucidate clinicopathologic manifestations of cutaneous lymphoproliferative disorders associated with Epstein-Barr virus (EBV) infection. Design: Retrospective survey of case series Setting: University hospital medical center. Patients: Sixty-five patients with cutaneous lymphomas and related disorders. Main Outcome Measures: Detection of EBV genes and EBV-encoded small nuclear RNAs. Results: Evidence of latent EBV infection was demonstrated in 15 patients: 3 had malignant lymphoma with clinical features mimicking cytophagic histiocytic panniculitis, 6 had facial vesiculopapular eruptions mimicking hydroa vacciniforme, 4 had angiocentric lymphoma, 1 had histiocytoid lymphoma associated with hemophagocytosis, and 1 had plasmacytoma. Hypersensitivity to mosquito bites was noted in a patient with hydroa vacciniforme-like eruptions and another with histiocytoid lymphoma. Angiocentric infiltration of atypical lymphoid cells was a common histological feature in the patients with hydroa vacciniforme-like eruptions and angiocentric lymphoma. No evidence of EBV infection was apparent in 19 patients with mycosis fungoides or Sezary syndrome, 7 with adult T-cell leukemia or lymphoma, 3 with lymphomatoid papulosis (type A), and 2 with lymphocytoma cutis. Conclusion: Patients with EBV-associated cutaneous lymphoproliferative disorders present with unique and diagnostic clinicopathologic features distinct from those of mycosis fungoides or Sezary syndrome.

Original languageEnglish
Pages (from-to)1081-1086
Number of pages6
JournalArchives of Dermatology
Issue number9
Publication statusPublished - Sept 1997
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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