Clinicopathologic manifestations of early-onset endometrial cancer in Japanese women with a familial predisposition to cancer

Wataru Yamagami, Nobuyuki Susumu, Kouji Banno, Takeshi Hirao, Fumio Kataoka, Akira Hirasawa, Nao Suzuki, Daisuke Aoki, Shiro Nozawa

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3 Citations (Scopus)


Aim: The number of patients under 40 years of age with early-onset endometrial cancer is on the rise in Japan. Preservation of fertility in younger patients is a critical issue. In order to examine the clinical and pathological characteristics of these patients, cases of early-onset endometrial cancer at a single hospital were analyzed. Methods: Seventy-four patients were diagnosed with endometrial cancer before age 40 and included in this study after obtaining informed consent. Results: The clinical characteristics included a significantly higher prevalence of complications such as nulligravidity and nulliparity (P < 0.001). Pathologically, well-differentiated endometrial carcinoma was significantly more frequent (P = 0.011). The 5-year survival rate was high (98.7%). In regards to the relationship between clinicopathological features and grade of differentiation, the prevalence of G2 and G3 carcinoma was not significantly lower (P = 0.24) in patients with obesity. Although the frequency of G2 and G3 carcinoma was significantly higher in patients with a family history of cancer (P = 0.02), their 5-year survival rate was not significantly lower (100%). Conclusion: This study found that these two types of early-onset endometrial cancer are clinicopathologically different. In patients with a family history of cancer, their body mass index was lower, and the frequency of G2 and G3 carcinoma was significantly higher, but their 5-year disease-free survival rate was not significantly lower.

Original languageEnglish
Pages (from-to)444-451
Number of pages8
JournalJournal of Obstetrics and Gynaecology Research
Issue number5
Publication statusPublished - Oct 1 2005



  • Endometrial cancer
  • Family history of cancer
  • Obesity

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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