Clinicopathologic analysis of IgG4-related skin disease

Yasuharu Sato, Mai Takeuchi, Katsuyoshi Takata, Kyotaro Ohno, Noriko Iwaki, Yorihisa Orita, Naoe Goto, Akira I. Hida, Toshiyuki Iwamoto, Naoko Asano, Toshihiro Ito, Hiroyuki Hanakawa, Hiroyuki Yanai, Tadashi Yoshino

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

IgG4-related disease is a recently recognized systemic syndrome characterized by mass-forming lesions with lymphoplasmacytic infiltration, increase in the number of IgG4 + cells in affected tissues and elevation of serum IgG4 levels. In 2009, we were the first to report skin lesions in patients with IgG4-related disease, but no large case series has been reported and clinicopathological findings remain unclear. To clarify these features, we herein report 10 patients (9 men and 1 woman; median age, 64 years; age range, 46-81 years) with IgG4-related skin disease. All patients had erythematous and itchy plaques or subcutaneous nodules on the skin of the head and neck, particularly in the periauricular, cheek, and mandible regions, except for one patient, whose forearm and waist skin were affected. In addition, eight patients had extracutaneous lesions: these were found on the lymph nodes in six patients, the lacrimal glands in three patients, the parotid glands in three patients, and the kidney in one patient. Histologically examined extracutaneous lesions were consistent with IgG4-related disease; five of six lymph node lesions showed progressively transformed germinal centers-type IgG4-related lymphadenopathy. Cases of IgG4-related skin disease were classified into two histological patterns: those exhibiting a nodular dermatitis pattern and those with a subcutaneous nodule pattern. The infiltrate was rich in plasma cells, small lymphocytes, and eosinophils; the majority of the plasma cells were IgG4 +. The IgG4 + cell count was 49-396 per high-power field (mean±s.d., 172±129), with an IgG4 +/IgG + cell ratio ranging from 62 to 92%. Serum IgG4 levels were elevated in all examined patients. In conclusion, patients with IgG4-related skin disease had uniform clinicopathology. Lesions were frequently present on the skin of the periauricular, cheek, and mandible regions, and were frequently accompanied by IgG4-related lymphadenopathy.

Original languageEnglish
Pages (from-to)523-532
Number of pages10
JournalModern Pathology
Volume26
Issue number4
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Skin Diseases
Immunoglobulin G
Skin
Cheek
Plasma Cells
Mandible
Cell Count
Lymph Nodes
Lacrimal Apparatus
Germinal Center
Parotid Gland
Dermatitis
Serum
Eosinophils
Forearm
Neck
Head

Keywords

  • IgG4-related disease
  • lymphadenopathy
  • periauricular region
  • progressively transformed germinal centers
  • skin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Clinicopathologic analysis of IgG4-related skin disease. / Sato, Yasuharu; Takeuchi, Mai; Takata, Katsuyoshi; Ohno, Kyotaro; Iwaki, Noriko; Orita, Yorihisa; Goto, Naoe; Hida, Akira I.; Iwamoto, Toshiyuki; Asano, Naoko; Ito, Toshihiro; Hanakawa, Hiroyuki; Yanai, Hiroyuki; Yoshino, Tadashi.

In: Modern Pathology, Vol. 26, No. 4, 04.2013, p. 523-532.

Research output: Contribution to journalArticle

Sato, Y, Takeuchi, M, Takata, K, Ohno, K, Iwaki, N, Orita, Y, Goto, N, Hida, AI, Iwamoto, T, Asano, N, Ito, T, Hanakawa, H, Yanai, H & Yoshino, T 2013, 'Clinicopathologic analysis of IgG4-related skin disease', Modern Pathology, vol. 26, no. 4, pp. 523-532. https://doi.org/10.1038/modpathol.2012.196
Sato Y, Takeuchi M, Takata K, Ohno K, Iwaki N, Orita Y et al. Clinicopathologic analysis of IgG4-related skin disease. Modern Pathology. 2013 Apr;26(4):523-532. https://doi.org/10.1038/modpathol.2012.196
Sato, Yasuharu ; Takeuchi, Mai ; Takata, Katsuyoshi ; Ohno, Kyotaro ; Iwaki, Noriko ; Orita, Yorihisa ; Goto, Naoe ; Hida, Akira I. ; Iwamoto, Toshiyuki ; Asano, Naoko ; Ito, Toshihiro ; Hanakawa, Hiroyuki ; Yanai, Hiroyuki ; Yoshino, Tadashi. / Clinicopathologic analysis of IgG4-related skin disease. In: Modern Pathology. 2013 ; Vol. 26, No. 4. pp. 523-532.
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