Clinicopathologic analysis of gastric mucosa-associated lymphoid tissue lymphoma with or without c-Met expression

Rika Omote, Yuka Gion, Shizuma Omote, Akira Tari, Takehiro Tanaka, Asami Nishikori, Tadashi Yoshino, Yasuharu Sato

Research output: Contribution to journalArticle

Abstract

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach is mainly associated with Helicobacter pylori infection, and H. pylori eradication therapy is often effective. However, 20–30% of the cases of MALT lymphoma are resistant to the eradication therapy, and translocation of the API2-MALT1 gene is often found in these cases. Most cases without translocation of API2-MALT1 are localized to the stomach, whereas some cases with this translocation are a more advanced stage of MALT lymphoma that spreads to other organs. The c-Met receptor is a prognostic factor involved in infiltration and metastasis in many malignant tumors, including gastric, pancreatic, lung, and kidney cancer. In the present study, the expression of c-Met in 43 cases of gastric MALT lymphomas was immunohistochemically examined and compared with clinicopathological factors. To elucidate the significance of c-Met in MALT lymphoma, the expression intensity of c-Met in 22 API2-MALT1 translocation-positive and 21 API2-MALT1 translocation-negative cases was scored, compared, and examined. The immunohistochemistry analysis revealed strong staining for c-Met in 21 API2-MALT1 translocation-positive cases and in 1 translocation-negative case (P = 0.00). This result indicates the relationship between strong expression of c-Met and the progression of MALT lymphoma with API2-MALT1 gene translocation.

Original languageEnglish
JournalMedical Molecular Morphology
DOIs
Publication statusAccepted/In press - Jan 1 2020

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Marginal Zone B-Cell Lymphoma
Gastric Mucosa
Helicobacter pylori
Stomach
Kidney Neoplasms
Helicobacter Infections
Pancreatic Neoplasms
Genes
Stomach Neoplasms
Lung Neoplasms
Immunohistochemistry
Staining and Labeling
Neoplasm Metastasis
Therapeutics

Keywords

  • c-Met protein
  • Chromosomal translocation
  • Eradication
  • Helicobacter pylori
  • HGF receptor
  • Mucosa-associated lymphoid tissue lymphoma
  • Stomach neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology

Cite this

Clinicopathologic analysis of gastric mucosa-associated lymphoid tissue lymphoma with or without c-Met expression. / Omote, Rika; Gion, Yuka; Omote, Shizuma; Tari, Akira; Tanaka, Takehiro; Nishikori, Asami; Yoshino, Tadashi; Sato, Yasuharu.

In: Medical Molecular Morphology, 01.01.2020.

Research output: Contribution to journalArticle

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