Clinicopathologic analysis of 6 lymphomatoid gastropathy cases: Expanding the disease spectrum to CD4-CD8+ Cases

Katsuyoshi Takata, Mai Noujima-Harada, Tomoko Miyata-Takata, Koichi Ichimura, Yasuharu Sato, Takafumi Miyata, Keishi Naruse, Toshiyuki Iwamoto, Akira Tari, Taro Masunari, Hiroshi Sonobe, Hiroyuki Okada, Masaya Iwamuro, Kohichi Mizobuchi, Yuka Gion, Tadashi Yoshino

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Lymphomatoid gastropathy, which was first reported in 2010, is a rare NK-cell proliferation of cyCD3+, CD4-, CD5-, CD8-, CD56+ phenotypes with unknown etiology. The diagnosis is challenging, as there is histopathologic similarity to malignant lymphoma. In the 2010 report on 10 cases, all lesions were located in the stomach, and all regressed without any therapy. In the present study, we analyzed 6 cases of lymphomatoid gastropathy by investigating the clinicopathologic, immunohistochemical, and molecular findings. Endoscopic and morphologic appearances of all cases were consistent with previous reports, but 2 cases showed previously unreported unique immunophenotypes of CD4-CD8+. Three of 6 patients underwent lower gastrointestinal examination (1 case underwent double-balloon endoscopic examination), but no patient had lesions in the lower gastrointestinal tract. No obvious difference of histology was found between the cases of CD4-CD8-typical phenotype and ones of CD4-CD8+ phenotype. Both cases had similar clinical behavior as the other 4 cases, implying that the spectrum of the disease is broader than initially thought. Careful clinical and endoscopic follow-up is required for the diagnosis of lymphomatoid gastropathy, and additional case studies and molecular studies are warranted to further investigate the pathophysiology of this peculiar benign mimic of lymphoma.

Original languageEnglish
Pages (from-to)1259-1266
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume39
Issue number9
Publication statusPublished - 2015

Fingerprint

Phenotype
Lymphoma
Lower Gastrointestinal Tract
Natural Killer Cells
Stomach
Histology
Cell Proliferation
Therapeutics

Keywords

  • A benign mimic of lymphoma
  • CD4
  • CD8
  • Lymphomatoid gastropathy

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)

Cite this

Clinicopathologic analysis of 6 lymphomatoid gastropathy cases : Expanding the disease spectrum to CD4-CD8+ Cases. / Takata, Katsuyoshi; Noujima-Harada, Mai; Miyata-Takata, Tomoko; Ichimura, Koichi; Sato, Yasuharu; Miyata, Takafumi; Naruse, Keishi; Iwamoto, Toshiyuki; Tari, Akira; Masunari, Taro; Sonobe, Hiroshi; Okada, Hiroyuki; Iwamuro, Masaya; Mizobuchi, Kohichi; Gion, Yuka; Yoshino, Tadashi.

In: American Journal of Surgical Pathology, Vol. 39, No. 9, 2015, p. 1259-1266.

Research output: Contribution to journalArticle

Takata, K, Noujima-Harada, M, Miyata-Takata, T, Ichimura, K, Sato, Y, Miyata, T, Naruse, K, Iwamoto, T, Tari, A, Masunari, T, Sonobe, H, Okada, H, Iwamuro, M, Mizobuchi, K, Gion, Y & Yoshino, T 2015, 'Clinicopathologic analysis of 6 lymphomatoid gastropathy cases: Expanding the disease spectrum to CD4-CD8+ Cases', American Journal of Surgical Pathology, vol. 39, no. 9, pp. 1259-1266.
Takata, Katsuyoshi ; Noujima-Harada, Mai ; Miyata-Takata, Tomoko ; Ichimura, Koichi ; Sato, Yasuharu ; Miyata, Takafumi ; Naruse, Keishi ; Iwamoto, Toshiyuki ; Tari, Akira ; Masunari, Taro ; Sonobe, Hiroshi ; Okada, Hiroyuki ; Iwamuro, Masaya ; Mizobuchi, Kohichi ; Gion, Yuka ; Yoshino, Tadashi. / Clinicopathologic analysis of 6 lymphomatoid gastropathy cases : Expanding the disease spectrum to CD4-CD8+ Cases. In: American Journal of Surgical Pathology. 2015 ; Vol. 39, No. 9. pp. 1259-1266.
@article{80961f139d1e412899bb755b53883afa,
title = "Clinicopathologic analysis of 6 lymphomatoid gastropathy cases: Expanding the disease spectrum to CD4-CD8+ Cases",
abstract = "Lymphomatoid gastropathy, which was first reported in 2010, is a rare NK-cell proliferation of cyCD3+, CD4-, CD5-, CD8-, CD56+ phenotypes with unknown etiology. The diagnosis is challenging, as there is histopathologic similarity to malignant lymphoma. In the 2010 report on 10 cases, all lesions were located in the stomach, and all regressed without any therapy. In the present study, we analyzed 6 cases of lymphomatoid gastropathy by investigating the clinicopathologic, immunohistochemical, and molecular findings. Endoscopic and morphologic appearances of all cases were consistent with previous reports, but 2 cases showed previously unreported unique immunophenotypes of CD4-CD8+. Three of 6 patients underwent lower gastrointestinal examination (1 case underwent double-balloon endoscopic examination), but no patient had lesions in the lower gastrointestinal tract. No obvious difference of histology was found between the cases of CD4-CD8-typical phenotype and ones of CD4-CD8+ phenotype. Both cases had similar clinical behavior as the other 4 cases, implying that the spectrum of the disease is broader than initially thought. Careful clinical and endoscopic follow-up is required for the diagnosis of lymphomatoid gastropathy, and additional case studies and molecular studies are warranted to further investigate the pathophysiology of this peculiar benign mimic of lymphoma.",
keywords = "A benign mimic of lymphoma, CD4, CD8, Lymphomatoid gastropathy",
author = "Katsuyoshi Takata and Mai Noujima-Harada and Tomoko Miyata-Takata and Koichi Ichimura and Yasuharu Sato and Takafumi Miyata and Keishi Naruse and Toshiyuki Iwamoto and Akira Tari and Taro Masunari and Hiroshi Sonobe and Hiroyuki Okada and Masaya Iwamuro and Kohichi Mizobuchi and Yuka Gion and Tadashi Yoshino",
year = "2015",
language = "English",
volume = "39",
pages = "1259--1266",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Clinicopathologic analysis of 6 lymphomatoid gastropathy cases

T2 - Expanding the disease spectrum to CD4-CD8+ Cases

AU - Takata, Katsuyoshi

AU - Noujima-Harada, Mai

AU - Miyata-Takata, Tomoko

AU - Ichimura, Koichi

AU - Sato, Yasuharu

AU - Miyata, Takafumi

AU - Naruse, Keishi

AU - Iwamoto, Toshiyuki

AU - Tari, Akira

AU - Masunari, Taro

AU - Sonobe, Hiroshi

AU - Okada, Hiroyuki

AU - Iwamuro, Masaya

AU - Mizobuchi, Kohichi

AU - Gion, Yuka

AU - Yoshino, Tadashi

PY - 2015

Y1 - 2015

N2 - Lymphomatoid gastropathy, which was first reported in 2010, is a rare NK-cell proliferation of cyCD3+, CD4-, CD5-, CD8-, CD56+ phenotypes with unknown etiology. The diagnosis is challenging, as there is histopathologic similarity to malignant lymphoma. In the 2010 report on 10 cases, all lesions were located in the stomach, and all regressed without any therapy. In the present study, we analyzed 6 cases of lymphomatoid gastropathy by investigating the clinicopathologic, immunohistochemical, and molecular findings. Endoscopic and morphologic appearances of all cases were consistent with previous reports, but 2 cases showed previously unreported unique immunophenotypes of CD4-CD8+. Three of 6 patients underwent lower gastrointestinal examination (1 case underwent double-balloon endoscopic examination), but no patient had lesions in the lower gastrointestinal tract. No obvious difference of histology was found between the cases of CD4-CD8-typical phenotype and ones of CD4-CD8+ phenotype. Both cases had similar clinical behavior as the other 4 cases, implying that the spectrum of the disease is broader than initially thought. Careful clinical and endoscopic follow-up is required for the diagnosis of lymphomatoid gastropathy, and additional case studies and molecular studies are warranted to further investigate the pathophysiology of this peculiar benign mimic of lymphoma.

AB - Lymphomatoid gastropathy, which was first reported in 2010, is a rare NK-cell proliferation of cyCD3+, CD4-, CD5-, CD8-, CD56+ phenotypes with unknown etiology. The diagnosis is challenging, as there is histopathologic similarity to malignant lymphoma. In the 2010 report on 10 cases, all lesions were located in the stomach, and all regressed without any therapy. In the present study, we analyzed 6 cases of lymphomatoid gastropathy by investigating the clinicopathologic, immunohistochemical, and molecular findings. Endoscopic and morphologic appearances of all cases were consistent with previous reports, but 2 cases showed previously unreported unique immunophenotypes of CD4-CD8+. Three of 6 patients underwent lower gastrointestinal examination (1 case underwent double-balloon endoscopic examination), but no patient had lesions in the lower gastrointestinal tract. No obvious difference of histology was found between the cases of CD4-CD8-typical phenotype and ones of CD4-CD8+ phenotype. Both cases had similar clinical behavior as the other 4 cases, implying that the spectrum of the disease is broader than initially thought. Careful clinical and endoscopic follow-up is required for the diagnosis of lymphomatoid gastropathy, and additional case studies and molecular studies are warranted to further investigate the pathophysiology of this peculiar benign mimic of lymphoma.

KW - A benign mimic of lymphoma

KW - CD4

KW - CD8

KW - Lymphomatoid gastropathy

UR - http://www.scopus.com/inward/record.url?scp=84942751194&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942751194&partnerID=8YFLogxK

M3 - Article

C2 - 25929350

AN - SCOPUS:84942751194

VL - 39

SP - 1259

EP - 1266

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 9

ER -