Clinical utility of a self-administered questionnaire for assessment of hereditary gynecologic cancer

Kenta Masuda, Akira Hirasawa, Haruko Irie-Kunitomi, Tomoko Akahane, Arisa Ueki, Yusuke Kobayashi, Wataru Yamagami, Hiroyuki Nomura, Fumio Kataoka, Eiichiro Tominaga, Kouji Banno, Nobuyuki Susumu, Daisuke Aoki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: A patient's medical history and familial cancer history are important information for assessing the risk of hereditary cancer. We have generated a self-administered questionnaire for patients with gynecologic cancer. This pilot study analyzed the usefulness of this questionnaire and the rates of patients that meet the Society of Gynecologic Oncology criteria in ovarian cancer and endometrial cancer patients.Method: Ovarian or endometrial cancer patients were recruited for this study. After informed consent was obtained, participants completed the questionnaire. Genetic risks were assessed from the data of each patient's questionnaire by Society of Gynecologic Oncology guideline. Clinical and pathological findings were compared between the genetic risk groups.Results: A total of 105 patients were identified with ovarian cancer and 56 patients with endometrial cancer eligible for this study. According to the Society of Gynecologic Oncology guideline, of the 105 ovarian cancer patients, 25 patients (23%) had a 20-25% risk and three patients (2.9%) had a 5-10% risk of hereditary breast and ovarian cancer syndrome. A further 22 patients (21%) had a 5-10% risk of Lynch syndrome. Two patients (1.9%) met the Amsterdam criteria II. Of 56 endometrial cancer patients, 24 patients (42.9%) had a 5-10% risk of Lynch syndrome. The endometrial cancer patients with genetic risk of Lynch syndrome were younger (mean age: 47.79) at diagnosis compared to patients without a genetic risk of Lynch syndrome (mean age: 57.91).Conclusions: In this study, we were able to show that the newly designed questionnaire is a useful tool for evaluating cancer family history along with Society of Gynecologic Oncology criteria or Amsterdam criteria II. When considering the risk of Lynch syndrome for a patient with ovarian cancer, it is important to collect a second and third relative's family history.

Original languageEnglish
Article numberhyx019
Pages (from-to)401-406
Number of pages6
JournalJapanese Journal of Clinical Oncology
Volume47
Issue number5
DOIs
Publication statusPublished - May 1 2017
Externally publishedYes

Fingerprint

Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms
Endometrial Neoplasms
Ovarian Neoplasms
Surveys and Questionnaires
Hereditary Breast and Ovarian Cancer Syndrome
Guidelines
Informed Consent

Keywords

  • Endometrial cancer
  • Family history
  • Hereditary breast and ovarian cancer syndrome
  • Lynch syndrome
  • Ovarian cancer
  • Self-administered questionnaire

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Clinical utility of a self-administered questionnaire for assessment of hereditary gynecologic cancer. / Masuda, Kenta; Hirasawa, Akira; Irie-Kunitomi, Haruko; Akahane, Tomoko; Ueki, Arisa; Kobayashi, Yusuke; Yamagami, Wataru; Nomura, Hiroyuki; Kataoka, Fumio; Tominaga, Eiichiro; Banno, Kouji; Susumu, Nobuyuki; Aoki, Daisuke.

In: Japanese Journal of Clinical Oncology, Vol. 47, No. 5, hyx019, 01.05.2017, p. 401-406.

Research output: Contribution to journalArticle

Masuda, K, Hirasawa, A, Irie-Kunitomi, H, Akahane, T, Ueki, A, Kobayashi, Y, Yamagami, W, Nomura, H, Kataoka, F, Tominaga, E, Banno, K, Susumu, N & Aoki, D 2017, 'Clinical utility of a self-administered questionnaire for assessment of hereditary gynecologic cancer', Japanese Journal of Clinical Oncology, vol. 47, no. 5, hyx019, pp. 401-406. https://doi.org/10.1093/jjco/hyx019
Masuda, Kenta ; Hirasawa, Akira ; Irie-Kunitomi, Haruko ; Akahane, Tomoko ; Ueki, Arisa ; Kobayashi, Yusuke ; Yamagami, Wataru ; Nomura, Hiroyuki ; Kataoka, Fumio ; Tominaga, Eiichiro ; Banno, Kouji ; Susumu, Nobuyuki ; Aoki, Daisuke. / Clinical utility of a self-administered questionnaire for assessment of hereditary gynecologic cancer. In: Japanese Journal of Clinical Oncology. 2017 ; Vol. 47, No. 5. pp. 401-406.
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AU - Hirasawa, Akira

AU - Irie-Kunitomi, Haruko

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AU - Ueki, Arisa

AU - Kobayashi, Yusuke

AU - Yamagami, Wataru

AU - Nomura, Hiroyuki

AU - Kataoka, Fumio

AU - Tominaga, Eiichiro

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AU - Susumu, Nobuyuki

AU - Aoki, Daisuke

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N2 - Background: A patient's medical history and familial cancer history are important information for assessing the risk of hereditary cancer. We have generated a self-administered questionnaire for patients with gynecologic cancer. This pilot study analyzed the usefulness of this questionnaire and the rates of patients that meet the Society of Gynecologic Oncology criteria in ovarian cancer and endometrial cancer patients.Method: Ovarian or endometrial cancer patients were recruited for this study. After informed consent was obtained, participants completed the questionnaire. Genetic risks were assessed from the data of each patient's questionnaire by Society of Gynecologic Oncology guideline. Clinical and pathological findings were compared between the genetic risk groups.Results: A total of 105 patients were identified with ovarian cancer and 56 patients with endometrial cancer eligible for this study. According to the Society of Gynecologic Oncology guideline, of the 105 ovarian cancer patients, 25 patients (23%) had a 20-25% risk and three patients (2.9%) had a 5-10% risk of hereditary breast and ovarian cancer syndrome. A further 22 patients (21%) had a 5-10% risk of Lynch syndrome. Two patients (1.9%) met the Amsterdam criteria II. Of 56 endometrial cancer patients, 24 patients (42.9%) had a 5-10% risk of Lynch syndrome. The endometrial cancer patients with genetic risk of Lynch syndrome were younger (mean age: 47.79) at diagnosis compared to patients without a genetic risk of Lynch syndrome (mean age: 57.91).Conclusions: In this study, we were able to show that the newly designed questionnaire is a useful tool for evaluating cancer family history along with Society of Gynecologic Oncology criteria or Amsterdam criteria II. When considering the risk of Lynch syndrome for a patient with ovarian cancer, it is important to collect a second and third relative's family history.

AB - Background: A patient's medical history and familial cancer history are important information for assessing the risk of hereditary cancer. We have generated a self-administered questionnaire for patients with gynecologic cancer. This pilot study analyzed the usefulness of this questionnaire and the rates of patients that meet the Society of Gynecologic Oncology criteria in ovarian cancer and endometrial cancer patients.Method: Ovarian or endometrial cancer patients were recruited for this study. After informed consent was obtained, participants completed the questionnaire. Genetic risks were assessed from the data of each patient's questionnaire by Society of Gynecologic Oncology guideline. Clinical and pathological findings were compared between the genetic risk groups.Results: A total of 105 patients were identified with ovarian cancer and 56 patients with endometrial cancer eligible for this study. According to the Society of Gynecologic Oncology guideline, of the 105 ovarian cancer patients, 25 patients (23%) had a 20-25% risk and three patients (2.9%) had a 5-10% risk of hereditary breast and ovarian cancer syndrome. A further 22 patients (21%) had a 5-10% risk of Lynch syndrome. Two patients (1.9%) met the Amsterdam criteria II. Of 56 endometrial cancer patients, 24 patients (42.9%) had a 5-10% risk of Lynch syndrome. The endometrial cancer patients with genetic risk of Lynch syndrome were younger (mean age: 47.79) at diagnosis compared to patients without a genetic risk of Lynch syndrome (mean age: 57.91).Conclusions: In this study, we were able to show that the newly designed questionnaire is a useful tool for evaluating cancer family history along with Society of Gynecologic Oncology criteria or Amsterdam criteria II. When considering the risk of Lynch syndrome for a patient with ovarian cancer, it is important to collect a second and third relative's family history.

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