TY - JOUR
T1 - Clinical study on BMY-28100
AU - Irabu, Yuei
AU - Tamaki, Kazunori
AU - Fukuhara, Hiroshi
AU - Nakamura, Hiroaki
AU - Kaneshima, Hiroshi
AU - Shimoji, Katsuyoshi
AU - Kitsukawa, Keizo
AU - Shigeno, Yoshiteru
AU - Saito, Atsushi
AU - Taira, Shinko
AU - Nakasone, Isamu
AU - Kusano, Nobuchika
AU - Hokama, Seitetsu
PY - 1989
Y1 - 1989
N2 - We performed clinical studies on BMY-28100, a new oral cephalosporin, with the following results. 1) Clinical efficacy : BMY-28100 750mg or 1500mg/day was given to 1 patient with acute suppurative tonsillitis, 3 patients with acute bronchitis, 1 with infection complicating pulmonary emphysema, 1 with pneumonia complicating chronic bronchitis, 1 with bronchiectasis, 3 with chronic bronchitis, 3 with bacterial pneumonia, and 1 with infection complicating bronchial asthma, for 2-13 days. Clinical response was excellent in 1, good in 4, fair in 3 and poor in 4 patients, while 1 patient was unevaluable. Clinical efficacy was 41.7%. 2) Bacteriological efficacy : Seven strains (3 of Haemophilus influenzae, 1 of Streptococcus pneumoniae, 1 of Enterobacter cloacae, 1 of Pseudomonas aeruginosa and 1 of Serratia marcescens) were isolated. One strain of E, cloacae was eradicated. One strain of S. pneumoniae was eradicated, but changed to Enterobacter aerogenes, and one strain of S. marcescens changed to H. influenzae and Klebsiella pneumoniae. Other isolated strains were not eradicated. Bacteriological efficacy was 50%. 3) Side effects and laboratory findings : Skin eruption as a side effect was observed in one patient, but no abnormal labolatory findings were observed.
AB - We performed clinical studies on BMY-28100, a new oral cephalosporin, with the following results. 1) Clinical efficacy : BMY-28100 750mg or 1500mg/day was given to 1 patient with acute suppurative tonsillitis, 3 patients with acute bronchitis, 1 with infection complicating pulmonary emphysema, 1 with pneumonia complicating chronic bronchitis, 1 with bronchiectasis, 3 with chronic bronchitis, 3 with bacterial pneumonia, and 1 with infection complicating bronchial asthma, for 2-13 days. Clinical response was excellent in 1, good in 4, fair in 3 and poor in 4 patients, while 1 patient was unevaluable. Clinical efficacy was 41.7%. 2) Bacteriological efficacy : Seven strains (3 of Haemophilus influenzae, 1 of Streptococcus pneumoniae, 1 of Enterobacter cloacae, 1 of Pseudomonas aeruginosa and 1 of Serratia marcescens) were isolated. One strain of E, cloacae was eradicated. One strain of S. pneumoniae was eradicated, but changed to Enterobacter aerogenes, and one strain of S. marcescens changed to H. influenzae and Klebsiella pneumoniae. Other isolated strains were not eradicated. Bacteriological efficacy was 50%. 3) Side effects and laboratory findings : Skin eruption as a side effect was observed in one patient, but no abnormal labolatory findings were observed.
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U2 - 10.11250/chemotherapy1953.37.Supplement3_475
DO - 10.11250/chemotherapy1953.37.Supplement3_475
M3 - Article
AN - SCOPUS:0024894071
VL - 37
SP - 475
EP - 478
JO - Chemotherapy
JF - Chemotherapy
SN - 0009-3165
ER -