Clinical study of influential factors on renal scarring after ESWL monotherapy for renal stone disease

Noritaka Ishito, Hitoshi Takamoto, Kimito Kunitomi, Eiichi Satoh, Ayano Ishii, Youichi Shiotuka, Shinichi Sako, Naoki Ohta, Tohru Araki

Research output: Contribution to journalArticle

Abstract

(Objective) ESWL is now widely used for the treatment of renal stone disease. Although ESWL has many advantages for patients' quality of life, few reports have demonstrated the long-term outcomes of the alterations of renal morphology after ESWL. We reported renal scarring after ESWL monotherapy in patients with renal calyceal stones. In this study, we evaluated a large series of patients' cohort treated at our institution, and assessed the causal effect of ESWL on the late occurrence of renal scar formation. (Patients and methods) ESWL was performed with EDAP (LT-01,02) that generates shock wave energy by piezoelectric discharge. We analyzed the records of 285 kidneys treated between Dec. 1986 and Nov. 1998. Renal scarring was noted in 44 kidneys and not in 241 kidneys with periodical ultrasonography. We compared the backgrounds of the two groups using chi-square or non-parametric analysis. The Kaplan-Meier method and Cox regression model determined the analysis of renal scar formation. (Results) Univariate and multiple regression analysis revealed that the total amount of ESWL emission and hyperuricemia independently affected the probability of renal scar formation. (Conclusions) Over-emission of ESWL (over 10000 shots) must be care for the prevention of renal scarring in patients with renal calyceal calculi, especially when associated with hyperuricemia. After ESWL, periodical checkups with ultrasonography will provide useful information for the clinical diagnosis of renal scarring.

Original languageEnglish
Pages (from-to)750-757
Number of pages8
JournalJapanese Journal of Urology
Volume93
Issue number7
Publication statusPublished - Nov 2002
Externally publishedYes

Fingerprint

Cicatrix
Kidney
Hyperuricemia
Clinical Studies
Ultrasonography
Kidney Calculi
Proportional Hazards Models
Regression Analysis
Quality of Life

Keywords

  • ESWL monotherapy
  • Hyperuricemia
  • Renal scarring

ASJC Scopus subject areas

  • Urology

Cite this

Ishito, N., Takamoto, H., Kunitomi, K., Satoh, E., Ishii, A., Shiotuka, Y., ... Araki, T. (2002). Clinical study of influential factors on renal scarring after ESWL monotherapy for renal stone disease. Japanese Journal of Urology, 93(7), 750-757.

Clinical study of influential factors on renal scarring after ESWL monotherapy for renal stone disease. / Ishito, Noritaka; Takamoto, Hitoshi; Kunitomi, Kimito; Satoh, Eiichi; Ishii, Ayano; Shiotuka, Youichi; Sako, Shinichi; Ohta, Naoki; Araki, Tohru.

In: Japanese Journal of Urology, Vol. 93, No. 7, 11.2002, p. 750-757.

Research output: Contribution to journalArticle

Ishito, N, Takamoto, H, Kunitomi, K, Satoh, E, Ishii, A, Shiotuka, Y, Sako, S, Ohta, N & Araki, T 2002, 'Clinical study of influential factors on renal scarring after ESWL monotherapy for renal stone disease', Japanese Journal of Urology, vol. 93, no. 7, pp. 750-757.
Ishito, Noritaka ; Takamoto, Hitoshi ; Kunitomi, Kimito ; Satoh, Eiichi ; Ishii, Ayano ; Shiotuka, Youichi ; Sako, Shinichi ; Ohta, Naoki ; Araki, Tohru. / Clinical study of influential factors on renal scarring after ESWL monotherapy for renal stone disease. In: Japanese Journal of Urology. 2002 ; Vol. 93, No. 7. pp. 750-757.
@article{ba60c27c0bdc40e3ae2bbe08588e8eda,
title = "Clinical study of influential factors on renal scarring after ESWL monotherapy for renal stone disease",
abstract = "(Objective) ESWL is now widely used for the treatment of renal stone disease. Although ESWL has many advantages for patients' quality of life, few reports have demonstrated the long-term outcomes of the alterations of renal morphology after ESWL. We reported renal scarring after ESWL monotherapy in patients with renal calyceal stones. In this study, we evaluated a large series of patients' cohort treated at our institution, and assessed the causal effect of ESWL on the late occurrence of renal scar formation. (Patients and methods) ESWL was performed with EDAP (LT-01,02) that generates shock wave energy by piezoelectric discharge. We analyzed the records of 285 kidneys treated between Dec. 1986 and Nov. 1998. Renal scarring was noted in 44 kidneys and not in 241 kidneys with periodical ultrasonography. We compared the backgrounds of the two groups using chi-square or non-parametric analysis. The Kaplan-Meier method and Cox regression model determined the analysis of renal scar formation. (Results) Univariate and multiple regression analysis revealed that the total amount of ESWL emission and hyperuricemia independently affected the probability of renal scar formation. (Conclusions) Over-emission of ESWL (over 10000 shots) must be care for the prevention of renal scarring in patients with renal calyceal calculi, especially when associated with hyperuricemia. After ESWL, periodical checkups with ultrasonography will provide useful information for the clinical diagnosis of renal scarring.",
keywords = "ESWL monotherapy, Hyperuricemia, Renal scarring",
author = "Noritaka Ishito and Hitoshi Takamoto and Kimito Kunitomi and Eiichi Satoh and Ayano Ishii and Youichi Shiotuka and Shinichi Sako and Naoki Ohta and Tohru Araki",
year = "2002",
month = "11",
language = "English",
volume = "93",
pages = "750--757",
journal = "Japanese Journal of Urology",
issn = "0021-5287",
publisher = "THE JAPANESE UROLOGICAL ASSOCIATION",
number = "7",

}

TY - JOUR

T1 - Clinical study of influential factors on renal scarring after ESWL monotherapy for renal stone disease

AU - Ishito, Noritaka

AU - Takamoto, Hitoshi

AU - Kunitomi, Kimito

AU - Satoh, Eiichi

AU - Ishii, Ayano

AU - Shiotuka, Youichi

AU - Sako, Shinichi

AU - Ohta, Naoki

AU - Araki, Tohru

PY - 2002/11

Y1 - 2002/11

N2 - (Objective) ESWL is now widely used for the treatment of renal stone disease. Although ESWL has many advantages for patients' quality of life, few reports have demonstrated the long-term outcomes of the alterations of renal morphology after ESWL. We reported renal scarring after ESWL monotherapy in patients with renal calyceal stones. In this study, we evaluated a large series of patients' cohort treated at our institution, and assessed the causal effect of ESWL on the late occurrence of renal scar formation. (Patients and methods) ESWL was performed with EDAP (LT-01,02) that generates shock wave energy by piezoelectric discharge. We analyzed the records of 285 kidneys treated between Dec. 1986 and Nov. 1998. Renal scarring was noted in 44 kidneys and not in 241 kidneys with periodical ultrasonography. We compared the backgrounds of the two groups using chi-square or non-parametric analysis. The Kaplan-Meier method and Cox regression model determined the analysis of renal scar formation. (Results) Univariate and multiple regression analysis revealed that the total amount of ESWL emission and hyperuricemia independently affected the probability of renal scar formation. (Conclusions) Over-emission of ESWL (over 10000 shots) must be care for the prevention of renal scarring in patients with renal calyceal calculi, especially when associated with hyperuricemia. After ESWL, periodical checkups with ultrasonography will provide useful information for the clinical diagnosis of renal scarring.

AB - (Objective) ESWL is now widely used for the treatment of renal stone disease. Although ESWL has many advantages for patients' quality of life, few reports have demonstrated the long-term outcomes of the alterations of renal morphology after ESWL. We reported renal scarring after ESWL monotherapy in patients with renal calyceal stones. In this study, we evaluated a large series of patients' cohort treated at our institution, and assessed the causal effect of ESWL on the late occurrence of renal scar formation. (Patients and methods) ESWL was performed with EDAP (LT-01,02) that generates shock wave energy by piezoelectric discharge. We analyzed the records of 285 kidneys treated between Dec. 1986 and Nov. 1998. Renal scarring was noted in 44 kidneys and not in 241 kidneys with periodical ultrasonography. We compared the backgrounds of the two groups using chi-square or non-parametric analysis. The Kaplan-Meier method and Cox regression model determined the analysis of renal scar formation. (Results) Univariate and multiple regression analysis revealed that the total amount of ESWL emission and hyperuricemia independently affected the probability of renal scar formation. (Conclusions) Over-emission of ESWL (over 10000 shots) must be care for the prevention of renal scarring in patients with renal calyceal calculi, especially when associated with hyperuricemia. After ESWL, periodical checkups with ultrasonography will provide useful information for the clinical diagnosis of renal scarring.

KW - ESWL monotherapy

KW - Hyperuricemia

KW - Renal scarring

UR - http://www.scopus.com/inward/record.url?scp=0036859080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036859080&partnerID=8YFLogxK

M3 - Article

C2 - 12494520

AN - SCOPUS:0036859080

VL - 93

SP - 750

EP - 757

JO - Japanese Journal of Urology

JF - Japanese Journal of Urology

SN - 0021-5287

IS - 7

ER -