TY - JOUR
T1 - Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan
AU - Ando, M.
AU - Hashimoto, E.
AU - Hashizume, H.
AU - Hyodo, K.
AU - Inoue, H.
AU - Kunisada, T.
AU - Maksimenko, A.
AU - Mori, K.
AU - Rubenstein, E.
AU - Roberson, J.
AU - Shimao, D.
AU - Sugiyama, H.
AU - Takeda, Ken
AU - Toyofuku, F.
AU - Ueno, E.
AU - Umetani, K.
AU - Wada, H.
AU - Pattanasiriwisawa, W.
N1 - Funding Information:
The current experiment was performed under the approval of KEK-PF-PAC (2003G045), SPring-8-PAC (2004A0484-NL3-np, 2003B0657-NM-np, 2003A0353-NL2-np, 2002B0622-NM-np, 2002B0621-NL2-np, 2002A0309-NL-np, 2002A0462-NL2-np, 2001A0137-CL-np, 2001A0340-NL-np, 2002A0175-NL2-np, 2002B0665-NL2-np), Hyogo-Prefecture-PAC (C03B24XU-5054N). M.Ando highly appreciates KEK Development Research Grant KEK/2003-31, a Joint Research Fund for the Project 2001–2003 Soken/K01-5 (The Graduate University for Advanced Studies) and Grant-in-Aid for Exploratory Research #15654042 from the Ministry of Education, Science, Sports and Culture. One of the authors W. Pattanasiriwisawa acknowledges the Thai Royal Jubilee Research Fund that has made her study for PhD in Japan possible.
PY - 2005/8/11
Y1 - 2005/8/11
N2 - This paper reports, the application of synchrotron radiation to basic medicine at SPring-8 involving instrumentation and medical application of imaging and scattering. Emphasis should be laid on X-ray dark-field imaging (DFI) whose goal is clinical diagnosis of organs that have been invisible by ordinary techniques. Development of this technique is under way both at SPring-8 and KEK. The X-ray optics of DFI comprises a Bragg asymmetric monochro-collimator and a Laue case analyzer with a diffraction index of 4 4 0 using the X-ray energy of 35 keV (λ=0.0354nm) in a parallel position. This analyzer that can provide with 80 mm×80 mm view size has 2.15 mm thickness. At present the spatial resolution is around 5-10 μm. Visibility of some organs such as soft bone tissue at excised human femoral head and breast cancer tissue is under test. This preliminary test shows that the DFI seems feasible in clinical diagnosis. Furthermore, a perspective view of application of synchrotron radiation to clinical medicine in Japan will be given.
AB - This paper reports, the application of synchrotron radiation to basic medicine at SPring-8 involving instrumentation and medical application of imaging and scattering. Emphasis should be laid on X-ray dark-field imaging (DFI) whose goal is clinical diagnosis of organs that have been invisible by ordinary techniques. Development of this technique is under way both at SPring-8 and KEK. The X-ray optics of DFI comprises a Bragg asymmetric monochro-collimator and a Laue case analyzer with a diffraction index of 4 4 0 using the X-ray energy of 35 keV (λ=0.0354nm) in a parallel position. This analyzer that can provide with 80 mm×80 mm view size has 2.15 mm thickness. At present the spatial resolution is around 5-10 μm. Visibility of some organs such as soft bone tissue at excised human femoral head and breast cancer tissue is under test. This preliminary test shows that the DFI seems feasible in clinical diagnosis. Furthermore, a perspective view of application of synchrotron radiation to clinical medicine in Japan will be given.
KW - Articular
KW - Clinical application
KW - Excised human femoral head
KW - KEK
KW - Laue diffraction filter
KW - Monochro-collimator
KW - Photon factory
KW - Pseudoclinical diagnosis
KW - Refraction
KW - SPring-8
KW - Synchrotron radiation
KW - X-ray dark-field imaging
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U2 - 10.1016/j.nima.2005.03.059
DO - 10.1016/j.nima.2005.03.059
M3 - Conference article
AN - SCOPUS:23144446704
VL - 548
SP - 1
EP - 16
JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
SN - 0168-9002
IS - 1-2
T2 - Proceedings of the 4th International Worhshop on Medical Applications of Synchrotron Radiation MASR 2004
Y2 - 23 September 2005 through 25 September 2005
ER -