Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan

M. Ando; E. Hashimoto; H. Hashizume; K. Hyodo; H. Inoue; T. Kunisada; A. Maksimenko; K. Mori; E. Rubenstein; J. Roberson; D. Shimao; H. Sugiyama; Ken Takeda; F. Toyofuku; E. Ueno; K. Umetani; H. Wada; W. Pattanasiriwisawa

doi:10.1016/j.nima.2005.03.059

Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan

M. Ando, E. Hashimoto, H. Hashizume, K. Hyodo, H. Inoue, T. Kunisada, A. Maksimenko, K. Mori, E. Rubenstein, J. Roberson, D. Shimao, H. Sugiyama, Ken Takeda, F. Toyofuku, E. Ueno, K. Umetani, H. Wada, W. Pattanasiriwisawa

Research output: Contribution to journal › Conference article › peer-review

22 Citations (Scopus)

Abstract

This paper reports, the application of synchrotron radiation to basic medicine at SPring-8 involving instrumentation and medical application of imaging and scattering. Emphasis should be laid on X-ray dark-field imaging (DFI) whose goal is clinical diagnosis of organs that have been invisible by ordinary techniques. Development of this technique is under way both at SPring-8 and KEK. The X-ray optics of DFI comprises a Bragg asymmetric monochro-collimator and a Laue case analyzer with a diffraction index of 4 4 0 using the X-ray energy of 35 keV (λ=0.0354nm) in a parallel position. This analyzer that can provide with 80 mm×80 mm view size has 2.15 mm thickness. At present the spatial resolution is around 5-10 μm. Visibility of some organs such as soft bone tissue at excised human femoral head and breast cancer tissue is under test. This preliminary test shows that the DFI seems feasible in clinical diagnosis. Furthermore, a perspective view of application of synchrotron radiation to clinical medicine in Japan will be given.

Original language	English
Pages (from-to)	1-16
Number of pages	16
Journal	Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume	548
Issue number	1-2
DOIs	https://doi.org/10.1016/j.nima.2005.03.059
Publication status	Published - Aug 11 2005
Event	Proceedings of the 4th International Worhshop on Medical Applications of Synchrotron Radiation MASR 2004 - Duration: Sep 23 2005 → Sep 25 2005

Keywords

Articular
Clinical application
Excised human femoral head
KEK
Laue diffraction filter
Monochro-collimator
Photon factory
Pseudoclinical diagnosis
Refraction
SPring-8
Synchrotron radiation
X-ray dark-field imaging

ASJC Scopus subject areas

Nuclear and High Energy Physics
Instrumentation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.nima.2005.03.059

Cite this

Ando, M., Hashimoto, E., Hashizume, H., Hyodo, K., Inoue, H., Kunisada, T., Maksimenko, A., Mori, K., Rubenstein, E., Roberson, J., Shimao, D., Sugiyama, H., Takeda, K., Toyofuku, F., Ueno, E., Umetani, K., Wada, H., & Pattanasiriwisawa, W. (2005). Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 548(1-2), 1-16. https://doi.org/10.1016/j.nima.2005.03.059

Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan. / Ando, M.; Hashimoto, E.; Hashizume, H.; Hyodo, K.; Inoue, H.; Kunisada, T.; Maksimenko, A.; Mori, K.; Rubenstein, E.; Roberson, J.; Shimao, D.; Sugiyama, H.; Takeda, Ken; Toyofuku, F.; Ueno, E.; Umetani, K.; Wada, H.; Pattanasiriwisawa, W.

In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 548, No. 1-2, 11.08.2005, p. 1-16.

Research output: Contribution to journal › Conference article › peer-review

Ando, M, Hashimoto, E, Hashizume, H, Hyodo, K, Inoue, H, Kunisada, T, Maksimenko, A, Mori, K, Rubenstein, E, Roberson, J, Shimao, D, Sugiyama, H, Takeda, K, Toyofuku, F, Ueno, E, Umetani, K, Wada, H & Pattanasiriwisawa, W 2005, 'Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 548, no. 1-2, pp. 1-16. https://doi.org/10.1016/j.nima.2005.03.059

Ando M, Hashimoto E, Hashizume H, Hyodo K, Inoue H, Kunisada T et al. Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2005 Aug 11;548(1-2):1-16. https://doi.org/10.1016/j.nima.2005.03.059

Ando, M. ; Hashimoto, E. ; Hashizume, H. ; Hyodo, K. ; Inoue, H. ; Kunisada, T. ; Maksimenko, A. ; Mori, K. ; Rubenstein, E. ; Roberson, J. ; Shimao, D. ; Sugiyama, H. ; Takeda, Ken ; Toyofuku, F. ; Ueno, E. ; Umetani, K. ; Wada, H. ; Pattanasiriwisawa, W. / Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan. In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2005 ; Vol. 548, No. 1-2. pp. 1-16.

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title = "Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan",

abstract = "This paper reports, the application of synchrotron radiation to basic medicine at SPring-8 involving instrumentation and medical application of imaging and scattering. Emphasis should be laid on X-ray dark-field imaging (DFI) whose goal is clinical diagnosis of organs that have been invisible by ordinary techniques. Development of this technique is under way both at SPring-8 and KEK. The X-ray optics of DFI comprises a Bragg asymmetric monochro-collimator and a Laue case analyzer with a diffraction index of 4 4 0 using the X-ray energy of 35 keV (λ=0.0354nm) in a parallel position. This analyzer that can provide with 80 mm×80 mm view size has 2.15 mm thickness. At present the spatial resolution is around 5-10 μm. Visibility of some organs such as soft bone tissue at excised human femoral head and breast cancer tissue is under test. This preliminary test shows that the DFI seems feasible in clinical diagnosis. Furthermore, a perspective view of application of synchrotron radiation to clinical medicine in Japan will be given.",

keywords = "Articular, Clinical application, Excised human femoral head, KEK, Laue diffraction filter, Monochro-collimator, Photon factory, Pseudoclinical diagnosis, Refraction, SPring-8, Synchrotron radiation, X-ray dark-field imaging",

author = "M. Ando and E. Hashimoto and H. Hashizume and K. Hyodo and H. Inoue and T. Kunisada and A. Maksimenko and K. Mori and E. Rubenstein and J. Roberson and D. Shimao and H. Sugiyama and Ken Takeda and F. Toyofuku and E. Ueno and K. Umetani and H. Wada and W. Pattanasiriwisawa",

note = "Funding Information: The current experiment was performed under the approval of KEK-PF-PAC (2003G045), SPring-8-PAC (2004A0484-NL3-np, 2003B0657-NM-np, 2003A0353-NL2-np, 2002B0622-NM-np, 2002B0621-NL2-np, 2002A0309-NL-np, 2002A0462-NL2-np, 2001A0137-CL-np, 2001A0340-NL-np, 2002A0175-NL2-np, 2002B0665-NL2-np), Hyogo-Prefecture-PAC (C03B24XU-5054N). M.Ando highly appreciates KEK Development Research Grant KEK/2003-31, a Joint Research Fund for the Project 2001–2003 Soken/K01-5 (The Graduate University for Advanced Studies) and Grant-in-Aid for Exploratory Research #15654042 from the Ministry of Education, Science, Sports and Culture. One of the authors W. Pattanasiriwisawa acknowledges the Thai Royal Jubilee Research Fund that has made her study for PhD in Japan possible.; Proceedings of the 4th International Worhshop on Medical Applications of Synchrotron Radiation MASR 2004 ; Conference date: 23-09-2005 Through 25-09-2005",

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doi = "10.1016/j.nima.2005.03.059",

language = "English",

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T1 - Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan

AU - Ando, M.

AU - Hashimoto, E.

AU - Hashizume, H.

AU - Hyodo, K.

AU - Inoue, H.

AU - Kunisada, T.

AU - Maksimenko, A.

AU - Mori, K.

AU - Rubenstein, E.

AU - Roberson, J.

AU - Shimao, D.

AU - Sugiyama, H.

AU - Takeda, Ken

AU - Toyofuku, F.

AU - Ueno, E.

AU - Umetani, K.

AU - Wada, H.

AU - Pattanasiriwisawa, W.

N1 - Funding Information: The current experiment was performed under the approval of KEK-PF-PAC (2003G045), SPring-8-PAC (2004A0484-NL3-np, 2003B0657-NM-np, 2003A0353-NL2-np, 2002B0622-NM-np, 2002B0621-NL2-np, 2002A0309-NL-np, 2002A0462-NL2-np, 2001A0137-CL-np, 2001A0340-NL-np, 2002A0175-NL2-np, 2002B0665-NL2-np), Hyogo-Prefecture-PAC (C03B24XU-5054N). M.Ando highly appreciates KEK Development Research Grant KEK/2003-31, a Joint Research Fund for the Project 2001–2003 Soken/K01-5 (The Graduate University for Advanced Studies) and Grant-in-Aid for Exploratory Research #15654042 from the Ministry of Education, Science, Sports and Culture. One of the authors W. Pattanasiriwisawa acknowledges the Thai Royal Jubilee Research Fund that has made her study for PhD in Japan possible.

PY - 2005/8/11

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N2 - This paper reports, the application of synchrotron radiation to basic medicine at SPring-8 involving instrumentation and medical application of imaging and scattering. Emphasis should be laid on X-ray dark-field imaging (DFI) whose goal is clinical diagnosis of organs that have been invisible by ordinary techniques. Development of this technique is under way both at SPring-8 and KEK. The X-ray optics of DFI comprises a Bragg asymmetric monochro-collimator and a Laue case analyzer with a diffraction index of 4 4 0 using the X-ray energy of 35 keV (λ=0.0354nm) in a parallel position. This analyzer that can provide with 80 mm×80 mm view size has 2.15 mm thickness. At present the spatial resolution is around 5-10 μm. Visibility of some organs such as soft bone tissue at excised human femoral head and breast cancer tissue is under test. This preliminary test shows that the DFI seems feasible in clinical diagnosis. Furthermore, a perspective view of application of synchrotron radiation to clinical medicine in Japan will be given.

AB - This paper reports, the application of synchrotron radiation to basic medicine at SPring-8 involving instrumentation and medical application of imaging and scattering. Emphasis should be laid on X-ray dark-field imaging (DFI) whose goal is clinical diagnosis of organs that have been invisible by ordinary techniques. Development of this technique is under way both at SPring-8 and KEK. The X-ray optics of DFI comprises a Bragg asymmetric monochro-collimator and a Laue case analyzer with a diffraction index of 4 4 0 using the X-ray energy of 35 keV (λ=0.0354nm) in a parallel position. This analyzer that can provide with 80 mm×80 mm view size has 2.15 mm thickness. At present the spatial resolution is around 5-10 μm. Visibility of some organs such as soft bone tissue at excised human femoral head and breast cancer tissue is under test. This preliminary test shows that the DFI seems feasible in clinical diagnosis. Furthermore, a perspective view of application of synchrotron radiation to clinical medicine in Japan will be given.

KW - Articular

KW - Clinical application

KW - Excised human femoral head

KW - KEK

KW - Laue diffraction filter

KW - Monochro-collimator

KW - Photon factory

KW - Pseudoclinical diagnosis

KW - Refraction

KW - SPring-8

KW - Synchrotron radiation

KW - X-ray dark-field imaging

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U2 - 10.1016/j.nima.2005.03.059

DO - 10.1016/j.nima.2005.03.059

M3 - Conference article

AN - SCOPUS:23144446704

VL - 548

SP - 1

EP - 16

JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

SN - 0168-9002

IS - 1-2

T2 - Proceedings of the 4th International Worhshop on Medical Applications of Synchrotron Radiation MASR 2004

Y2 - 23 September 2005 through 25 September 2005

ER -

Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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