Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan

M. Ando, E. Hashimoto, H. Hashizume, K. Hyodo, H. Inoue, Toshiyuki Kunisada, A. Maksimenko, K. Mori, E. Rubenstein, J. Roberson, D. Shimao, H. Sugiyama, K. Takeda, F. Toyofuku, E. Ueno, K. Umetani, H. Wada, W. Pattanasiriwisawa

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22 Citations (Scopus)

Abstract

This paper reports, the application of synchrotron radiation to basic medicine at SPring-8 involving instrumentation and medical application of imaging and scattering. Emphasis should be laid on X-ray dark-field imaging (DFI) whose goal is clinical diagnosis of organs that have been invisible by ordinary techniques. Development of this technique is under way both at SPring-8 and KEK. The X-ray optics of DFI comprises a Bragg asymmetric monochro-collimator and a Laue case analyzer with a diffraction index of 4 4 0 using the X-ray energy of 35 keV (λ=0.0354nm) in a parallel position. This analyzer that can provide with 80 mm×80 mm view size has 2.15 mm thickness. At present the spatial resolution is around 5-10 μm. Visibility of some organs such as soft bone tissue at excised human femoral head and breast cancer tissue is under test. This preliminary test shows that the DFI seems feasible in clinical diagnosis. Furthermore, a perspective view of application of synchrotron radiation to clinical medicine in Japan will be given.

Original languageEnglish
Pages (from-to)1-16
Number of pages16
JournalNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume548
Issue number1-2
DOIs
Publication statusPublished - Aug 11 2005

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Keywords

  • Articular
  • Clinical application
  • Excised human femoral head
  • KEK
  • Laue diffraction filter
  • Monochro-collimator
  • Photon factory
  • Pseudoclinical diagnosis
  • Refraction
  • SPring-8
  • Synchrotron radiation
  • X-ray dark-field imaging

ASJC Scopus subject areas

  • Instrumentation
  • Nuclear and High Energy Physics

Cite this

Ando, M., Hashimoto, E., Hashizume, H., Hyodo, K., Inoue, H., Kunisada, T., Maksimenko, A., Mori, K., Rubenstein, E., Roberson, J., Shimao, D., Sugiyama, H., Takeda, K., Toyofuku, F., Ueno, E., Umetani, K., Wada, H., & Pattanasiriwisawa, W. (2005). Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 548(1-2), 1-16. https://doi.org/10.1016/j.nima.2005.03.059