Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan

M. Ando; E. Hashimoto; H. Hashizume; K. Hyodo; H. Inoue; Toshiyuki Kunisada; A. Maksimenko; K. Mori; E. Rubenstein; J. Roberson; D. Shimao; H. Sugiyama; K. Takeda; F. Toyofuku; E. Ueno; K. Umetani; H. Wada; W. Pattanasiriwisawa

doi:10.1016/j.nima.2005.03.059

Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan

M. Ando, E. Hashimoto, H. Hashizume, K. Hyodo, H. Inoue, Toshiyuki Kunisada, A. Maksimenko, K. Mori, E. Rubenstein, J. Roberson, D. Shimao, H. Sugiyama, K. Takeda, F. Toyofuku, E. Ueno, K. Umetani, H. Wada, W. Pattanasiriwisawa

Research output: Contribution to journal › Article

22 Citations (Scopus)

Abstract

This paper reports, the application of synchrotron radiation to basic medicine at SPring-8 involving instrumentation and medical application of imaging and scattering. Emphasis should be laid on X-ray dark-field imaging (DFI) whose goal is clinical diagnosis of organs that have been invisible by ordinary techniques. Development of this technique is under way both at SPring-8 and KEK. The X-ray optics of DFI comprises a Bragg asymmetric monochro-collimator and a Laue case analyzer with a diffraction index of 4 4 0 using the X-ray energy of 35 keV (λ=0.0354nm) in a parallel position. This analyzer that can provide with 80 mm×80 mm view size has 2.15 mm thickness. At present the spatial resolution is around 5-10 μm. Visibility of some organs such as soft bone tissue at excised human femoral head and breast cancer tissue is under test. This preliminary test shows that the DFI seems feasible in clinical diagnosis. Furthermore, a perspective view of application of synchrotron radiation to clinical medicine in Japan will be given.

Original language	English
Pages (from-to)	1-16
Number of pages	16
Journal	Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume	548
Issue number	1-2
DOIs	https://doi.org/10.1016/j.nima.2005.03.059
Publication status	Published - Aug 11 2005

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Keywords

Articular
Clinical application
Excised human femoral head
KEK
Laue diffraction filter
Monochro-collimator
Photon factory
Pseudoclinical diagnosis
Refraction
SPring-8
Synchrotron radiation
X-ray dark-field imaging

ASJC Scopus subject areas

Instrumentation
Nuclear and High Energy Physics

Cite this

Ando, M., Hashimoto, E., Hashizume, H., Hyodo, K., Inoue, H., Kunisada, T., Maksimenko, A., Mori, K., Rubenstein, E., Roberson, J., Shimao, D., Sugiyama, H., Takeda, K., Toyofuku, F., Ueno, E., Umetani, K., Wada, H., & Pattanasiriwisawa, W. (2005). Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 548(1-2), 1-16. https://doi.org/10.1016/j.nima.2005.03.059

Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan. / Ando, M.; Hashimoto, E.; Hashizume, H.; Hyodo, K.; Inoue, H.; Kunisada, Toshiyuki; Maksimenko, A.; Mori, K.; Rubenstein, E.; Roberson, J.; Shimao, D.; Sugiyama, H.; Takeda, K.; Toyofuku, F.; Ueno, E.; Umetani, K.; Wada, H.; Pattanasiriwisawa, W.

In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 548, No. 1-2, 11.08.2005, p. 1-16.

Research output: Contribution to journal › Article

Ando, M, Hashimoto, E, Hashizume, H, Hyodo, K, Inoue, H, Kunisada, T, Maksimenko, A, Mori, K, Rubenstein, E, Roberson, J, Shimao, D, Sugiyama, H, Takeda, K, Toyofuku, F, Ueno, E, Umetani, K, Wada, H & Pattanasiriwisawa, W 2005, 'Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 548, no. 1-2, pp. 1-16. https://doi.org/10.1016/j.nima.2005.03.059

Ando M, Hashimoto E, Hashizume H, Hyodo K, Inoue H, Kunisada T et al. Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2005 Aug 11;548(1-2):1-16. https://doi.org/10.1016/j.nima.2005.03.059

Ando, M. ; Hashimoto, E. ; Hashizume, H. ; Hyodo, K. ; Inoue, H. ; Kunisada, Toshiyuki ; Maksimenko, A. ; Mori, K. ; Rubenstein, E. ; Roberson, J. ; Shimao, D. ; Sugiyama, H. ; Takeda, K. ; Toyofuku, F. ; Ueno, E. ; Umetani, K. ; Wada, H. ; Pattanasiriwisawa, W. / Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan. In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2005 ; Vol. 548, No. 1-2. pp. 1-16.

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10.1016/j.nima.2005.03.059