Clinical spectrum of primary mediastinal tumors: A comparison of adult and pediatric populations at a single Japanese institution

Shin Ichi Takeda, Shinichiro Miyoshi, Akinori Akashi, Mitsunori Ohta, Masato Minami, Meinoshin Okumura, Akira Masaoka, Hikaru Matsuda

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Background and Objectives: The purpose of this study was to review our Japanese institutional experience of mediastinal tumors and to compare differences in the clinical spectrum between adults and children. Methods: We retrospectively reviewed the records of 806 patients (676 adults and 130 children) between 1951 and 2000 at our institution. Results: There were 244 thymomas (36%), 106 germ cell tumors (16%), 95 congenital cysts (14%), 82 lymphomas (12%), 76 neurogenic tumors (11%), and 24 thyroid tumors (4%) in adult patients. There were 60 neurogenic tumors (46%), 24 germ cell tumor (19%), 17 lymphoma (13%), 10 congenital cysts (8%), and 5 thymomas (4%) in the pediatric patients. There was a significant higher incidence of neurogenic tumors and a lower incidence of thymomas and thyroid tumors in children than adults. The most common location was the anterior compartment (68%) in adults and the posterior compartment in children (52%). The prevalence of malignancy in pediatric patients was lower than adults (37% vs. 47%; P <0.05). Symptoms due to compression or direct invasion into adjacent structures may have caused the higher incidence of dyspnea or respiratory distress in the pediatric group compared to the adults (15.4% vs. 4.0%; P <0.001). There were fewer incidences of facial edema in children compared to adults (2.6% vs. 10.7%; P <0.02). Emergent operations were required more often in the pediatric group than the adult group. Conclusions: We demonstrated definite differences in histologic distribution, location, and symptomatology in mediastinal tumors between adult and pediatric populations, which should be considered in the evaluation and planning of a therapeutic modality for mediastinal tumors.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalJournal of Surgical Oncology
Volume83
Issue number1
DOIs
Publication statusPublished - May 1 2003
Externally publishedYes

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Pediatrics
Population
Neoplasms
Thymoma
Germ Cell and Embryonal Neoplasms
Incidence
Cysts
Lymphoma
Thyroid Gland
Dyspnea
Edema

Keywords

  • Age distribution
  • Asian experience
  • Mediastinal tumor
  • Symptomatology

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Clinical spectrum of primary mediastinal tumors : A comparison of adult and pediatric populations at a single Japanese institution. / Takeda, Shin Ichi; Miyoshi, Shinichiro; Akashi, Akinori; Ohta, Mitsunori; Minami, Masato; Okumura, Meinoshin; Masaoka, Akira; Matsuda, Hikaru.

In: Journal of Surgical Oncology, Vol. 83, No. 1, 01.05.2003, p. 24-30.

Research output: Contribution to journalArticle

Takeda, SI, Miyoshi, S, Akashi, A, Ohta, M, Minami, M, Okumura, M, Masaoka, A & Matsuda, H 2003, 'Clinical spectrum of primary mediastinal tumors: A comparison of adult and pediatric populations at a single Japanese institution', Journal of Surgical Oncology, vol. 83, no. 1, pp. 24-30. https://doi.org/10.1002/jso.10231
Takeda, Shin Ichi ; Miyoshi, Shinichiro ; Akashi, Akinori ; Ohta, Mitsunori ; Minami, Masato ; Okumura, Meinoshin ; Masaoka, Akira ; Matsuda, Hikaru. / Clinical spectrum of primary mediastinal tumors : A comparison of adult and pediatric populations at a single Japanese institution. In: Journal of Surgical Oncology. 2003 ; Vol. 83, No. 1. pp. 24-30.
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AU - Ohta, Mitsunori

AU - Minami, Masato

AU - Okumura, Meinoshin

AU - Masaoka, Akira

AU - Matsuda, Hikaru

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KW - Age distribution

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KW - Symptomatology

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