Clinical significance of T1-weighted MR images following transient cerebral ischemia

Hisami Aoe, Yoshimasa Takeda, Hidero Kawahara, Akio Tanaka, Kiyoshi Morita

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To try to determine the cause of hyperintensity of T1-weighted MR images that occurred on and after day 7 following transient cerebral ischemia, dynamic changes in T1-weighted images and histology of rats subjected to 20 min of 4-vessel occlusion were observed. T1-weighted images showed no remarkable alteration on days 1 and 3, although high signal intensity in the striatal region, in which the T1 value was significantly lower than the values on days 1 and 3, was observed on day 7. High signal intensity in T1-weighted images indicates low T1 values. Histological observation revealed accumulation of microglia in the striatal region on day 7 by lectin staining. There was a tight correlation between T1 values and number of lectin-positive cells. Microglia had stout processes and hypertrophic cell bodies on day 7, resembling lipid-laden phagocytes. Sudan black B staining showed the presence of many fatty droplets in the striatal region on day 7. Furthermore, double staining with lectin and Sudan black B revealed the presence of fatty droplets in bodies of lectin-positive cells on day 7. These results suggest that hyperintensity of T1-weighted images on day 7 following transient ischemia and reperfusion indicates accumulation and phagocytic activation of microglia. T1-weighted images seem to represent the progression of non-reversible tissue injury after transient ischemia and reperfusion.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalJournal of the Neurological Sciences
Volume241
Issue number1-2
DOIs
Publication statusPublished - Feb 15 2006

Fingerprint

Transient Ischemic Attack
Corpus Striatum
Lectins
Microglia
Staining and Labeling
Reperfusion
Ischemia
Phagocytes
Histology
Observation
Lipids
Wounds and Injuries
Sudan Black B

Keywords

  • Basal ganglia
  • Cardiopulmonary resuscitation
  • Cerebral ischemia
  • Magnetic resonance imaging
  • Microglia
  • T1-weighted images

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Clinical significance of T1-weighted MR images following transient cerebral ischemia. / Aoe, Hisami; Takeda, Yoshimasa; Kawahara, Hidero; Tanaka, Akio; Morita, Kiyoshi.

In: Journal of the Neurological Sciences, Vol. 241, No. 1-2, 15.02.2006, p. 19-24.

Research output: Contribution to journalArticle

Aoe, Hisami ; Takeda, Yoshimasa ; Kawahara, Hidero ; Tanaka, Akio ; Morita, Kiyoshi. / Clinical significance of T1-weighted MR images following transient cerebral ischemia. In: Journal of the Neurological Sciences. 2006 ; Vol. 241, No. 1-2. pp. 19-24.
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