Clinical significance of serum pre-S(1) and pre-S(2) gene coded polypeptide of hepatitis B virus

Yoshiaki Iwasaki, Hiroshi Ikeda, Kazuhiro Nouso, Kouichi Takaguchi, Hiroyuki Shimomura, Takao Tsuji, Kazuharu Matsuura, Takahiro Yamabuki

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Abstract

An enzyme-linked immunosorbent assay (ELISA) was developed to detect polypeptides coded by the pre-S (1) and pre-S (2) region of hepatitis B virus (HBV) DNA with monoclonal antibody in 100 sera containing hepatitis B surface antigen particles. There can be seen a close correlation between the titer of pre-S (1) polypeptide and HBV-DNA level (HBV-asymptomatic carrier; n=40, r=0.800, p<0.01, chronic hepatitis type B; n=60, r=0.730, p<0.01). Ten patients with chronic hepatitis type B was devided into two groups (group 1: serum transaminase normalized after acute exacerbation (AE), group 2: abnormality of serum transaminase continued after AE). The titer of pre-S (1) polypeptide as well as HBV-DNA level was significantly reduced after AE in group 1 and group 2. But the titer of pre-S (2) polypeptide was more significantly reduced after AE in group 1 than in group 2. These results suggest that the detection of serum pre-S (2) polypeptide is more useful as a prognostic test for chronic hepatitis type B than pre-S (1) polypeptide.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalJapanese Journal of Clinical Immunology
Volume12
Issue number2
DOIs
Publication statusPublished - 1989

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Keywords

  • ELISA
  • HBV-DNA
  • hepatitis B virus
  • pre-S(1) antigen
  • pre-S(2) antigen

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Iwasaki, Y., Ikeda, H., Nouso, K., Takaguchi, K., Shimomura, H., Tsuji, T., Matsuura, K., & Yamabuki, T. (1989). Clinical significance of serum pre-S(1) and pre-S(2) gene coded polypeptide of hepatitis B virus. Japanese Journal of Clinical Immunology, 12(2), 259-263. https://doi.org/10.2177/jsci.12.259