TY - JOUR
T1 - Clinical significance of serum oxidized low-density lipoprotein/ β2-glycoprotein I complexes in patients with chronic renal diseases
AU - Kasahara, Junko
AU - Kobayashi, Kazuko
AU - Maeshima, Yohei
AU - Yamasaki, Yasushi
AU - Yasuda, Tatsuji
AU - Matsuura, Eiji
AU - Makino, Hirofumi
PY - 2004
Y1 - 2004
N2 - Background: Peroxidation of low-density lipoprotein (LDL) plays an important role in the development of dyslipidemias associated with the progression of chronic renal disorders. We recently reported [J Lipid Res 2001;42:697, 2002;43:1486, 2003;44:716] that oxidized LDL (oxLDL) interacts with an endogenous plasma protein, β2-glycoprotein I (β2GPI), via specific ligands. In the present study, the prevalence and clinical significance of oxLDL/β2GPI complexes were evaluated in patients with chronic renal disorders. Methods: Serum levels of oxLDL/β2GPI complexes were measured by ELISA in patients with chronic renal disease and their association with clinical manifestations was assessed. Results: The serum levels of oxLDL/β2GPI complexes were significantly higher in patients with chronic renal failure (CRF), chronic nephritis (CN) and diabetes mellitus than those in healthy individuals. The presence of complexes in patients with CN was significantly associated with high dietary protein and sodium chloride intake, but not with lipid metabolic parameters. Malondialdehyde-modified LDL was significantly associated with total cholesterol and LDL cholesterol in all patient groups, but did not correlate with renal function parameters. Conclusions: Serum oxLDL/β2GPI complexes, generated by oxidative stress and associated with high dietary protein and salt intake, might be a novel risk factor and a diagnostic marker for the development of chronic renal diseases, especially IgA nephropathy.
AB - Background: Peroxidation of low-density lipoprotein (LDL) plays an important role in the development of dyslipidemias associated with the progression of chronic renal disorders. We recently reported [J Lipid Res 2001;42:697, 2002;43:1486, 2003;44:716] that oxidized LDL (oxLDL) interacts with an endogenous plasma protein, β2-glycoprotein I (β2GPI), via specific ligands. In the present study, the prevalence and clinical significance of oxLDL/β2GPI complexes were evaluated in patients with chronic renal disorders. Methods: Serum levels of oxLDL/β2GPI complexes were measured by ELISA in patients with chronic renal disease and their association with clinical manifestations was assessed. Results: The serum levels of oxLDL/β2GPI complexes were significantly higher in patients with chronic renal failure (CRF), chronic nephritis (CN) and diabetes mellitus than those in healthy individuals. The presence of complexes in patients with CN was significantly associated with high dietary protein and sodium chloride intake, but not with lipid metabolic parameters. Malondialdehyde-modified LDL was significantly associated with total cholesterol and LDL cholesterol in all patient groups, but did not correlate with renal function parameters. Conclusions: Serum oxLDL/β2GPI complexes, generated by oxidative stress and associated with high dietary protein and salt intake, might be a novel risk factor and a diagnostic marker for the development of chronic renal diseases, especially IgA nephropathy.
KW - Enzyme-linked immunosorbent assay
KW - Kidney diseases
KW - Oxidized low-density lipoprotein
KW - β-Glycoprotein I
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U2 - 10.1159/000079923
DO - 10.1159/000079923
M3 - Article
C2 - 15361700
AN - SCOPUS:4644264529
VL - 98
SP - c15-c24
JO - Nephron - Clinical Practice
JF - Nephron - Clinical Practice
SN - 1660-2110
IS - 1
ER -
